Identification and Functional Characterization of Voltage-dependent Calcium Channels in T Lymphocytes

The versatility and universality of calcium signalling

2000 • 5,407 citations

Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway

2001 • 908 citations

Calcium Signaling Mechanisms in T Lymphocytes

2001 • 841 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Loss-of-function mutations in a calcium-channel α1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness

1998 • 505 citations

An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness

1998 • 493 citations

Immunocyte Ca ²⁺ Influx System Mediated by LTRPC2

2001 • 434 citations

Molecular properties of inositol 1,4,5-trisphosphate receptors

1999 • 408 citations

MOLECULAR DETERMINANTS OF DRUG BINDING AND ACTION ON L-TYPE CALCIUM CHANNELS

1997 • 385 citations

CaT1 manifests the pore properties of the calcium-release-activated calcium channel

2001 • 350 citations

Voltage-dependent calcium channels: From structure to function

2005 • 341 citations

T cell antigen-receptor signal transduction

1999 • 240 citations

PtdIns-3,4,5-P3

1998 • 220 citations

Expression of NFAT-Family Proteins in Normal Human T Cells

1997 • 176 citations

The interference of T cell activation by calcium channel blocking agents.

1984 • 156 citations

The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling.

1995 • 143 citations

Single-Channel Recording of a Store-Operated Ca ²⁺ Channel in Jurkat T Lymphocytes

1999 • 139 citations

Analysis of the Dihydropyridine Receptor Site ofl-type Calcium Channels by Alanine-scanning Mutagenesis

1997 • 98 citations

Single Channel Properties and Regulated Expression of Ca2+ Release-Activated Ca2+ (Crac) Channels in Human T Cells

2000 • 91 citations

Characterization of the role for calcium influx in mitogen‐induced triggering of human T cells. Identification of calcium‐dependent and calcium‐independent signals

1986 • 86 citations

Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products

2002 • 81 citations

Two Amino Acid Residues in the IIIS5 Segment of L-Type Calcium Channels Differentially Contribute to 1,4-Dihydropyridine Sensitivity

1996 • 81 citations

CaT1 Contributes to the Stores-operated Calcium Current in Jurkat T-lymphocytes

2002 • 80 citations

Ca2+ Signaling in T-Lymphocytes

1998 • 65 citations

Evidence that type I, II, and III inositol 1,4,5 trisphosphate receptors can occur as integral plasma membrane proteins

2000 • 60 citations

Characterization of nifedipine block of the human heart delayed rectifier, hKv1.5.

1997 • 60 citations

Molecular basis of drug interaction with L-type Ca2+ channels.

1998 • 56 citations

Calcium-induced ERK activation in human T lymphocytes occurs via p56Lck and CaM-kinase

2000 • 55 citations

rig encodes ribosomal protein S15 The primary structure of mammalian ribosomal protein S15

1991 • 53 citations

Protein kinase C‐mediated calcium entry dependent upon dihydropyridine‐sensitive channels: a T‐cell receptor‐coupled signaling pathway involved in interleukin 4 synthesis

2001 • 51 citations

Dihydropyridine Calcium Antagonists in Mice: Blood and Brain Pharmacokinetics and Efficacy Against Pentylenetetrazol Seizures

1992 • 51 citations

Evidence That Type I, II, and III Inositol 1,4,5-Trisphosphate Receptors Can Occur as Integral Plasma Membrane Proteins

2000 • 50 citations

Functional importance of the dihydropyridine‐sensitive, yet voltage‐insensitive store‐operated Ca²⁺ influx of U937 cells

1996 • 45 citations

Absence of CD43 Fails to Alter T Cell Development and Responsiveness

2001 • 40 citations

Novel variants of voltage-operated calcium channel α1-subunit transcripts in a rat liver-derived cell line: deletion in the IVS4 voltage sensing region

1997 • 40 citations

Nifedipine inhibits calcium-activated K transport in human erythrocytes

1990 • 40 citations

Three intracellular signals for cytotoxic T lymphocyte-mediated killing. Independent roles for protein kinase C, Ca2+ influx, and Ca2+ release from internal stores.

1991 • 39 citations

Calcium-induced ERK activation in human T lymphocytes

1999 • 35 citations

T cell signaling:

1999 • 33 citations

T-cell-receptor signalling in inositol 1,4,5-trisphosphate receptor (IP3R) type-1-deficient mice: is IP3R type 1 essential for T-cell-receptor signalling?

1998 • 33 citations

Additive Effects of Calcium Antagonists on Cyclosporin A-Induced Inhibition of T-Cell Proliferation

1990 • 32 citations

Inhibitory effects of dihydropyridines on macroscopic K+ currents and on the large-conductance Ca2+-activated K+ channel in cultured cerebellar granule cells

1994 • 30 citations

A voltage‐gated calcium channel is linked to the antigen receptor in Jurkat T lymphocytes

1992 • 26 citations

A voltage-operable current is involved in Ca2+ entry in human lymphocytes whereas ICRAC has no apparent role

1996 • 22 citations

Complex influence of the L-type calcium-channel agonist bayk8644(±) on N-methyl-d-aspartate responses and neuronal survival

1999 • 20 citations

Dihydropyridine Bay K 8644 activates T lymphocyte calcium-permeable channels.

1988 • 18 citations

Decreased lymphocyte blastogenesis, IL2 production and NK activity following nifedipine administration to healthy humans

1990 • 17 citations

Serum concentration-effect relationship of (±)-nicardipine and nifedipine in elderly hypertensive patients

1992 • 8 citations

The Most Commonly Prescribed Medications in the United States

1995 • 1 citations