Hypoxic Regulation of Angiopoietin-2 Expression in Endothelial Cells

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

1999 • 2,176 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

1997 • 1,901 citations

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

1999 • 1,372 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1

2002 • 993 citations

Signal transduction to hypoxia-inducible factor 1

2002 • 843 citations

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

1999 • 830 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

1997 • 792 citations

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

1997 • 775 citations

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1993 • 740 citations

Host cyclooxygenase-2 modulates carcinoma growth

2000 • 693 citations

Tie2 Receptor Ligands, Angiopoietin-1 and Angiopoietin-2, Modulate VEGF-Induced Postnatal Neovascularization

1998 • 680 citations

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

1997 • 673 citations

Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo

2002 • 639 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Cobalt Inhibits the Interaction between Hypoxia-inducible Factor-α and von Hippel-Lindau Protein by Direct Binding to Hypoxia-inducible Factor-α

2003 • 583 citations

Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis

1995 • 565 citations

Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells

1999 • 490 citations

Tie receptors: new modulators of angiogenic and lymphangiogenic responses

2001 • 412 citations

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

1997 • 410 citations

Regulation of Angiopoietin-2 mRNA Levels in Bovine Microvascular Endothelial Cells by Cytokines and Hypoxia

1998 • 379 citations

Induction of Interleukin 6 (IL-6) by Hypoxia in Vascular Cells

1995 • 348 citations

Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF)

2002 • 335 citations

Molecular Regulation of the Endothelin-1 Gene by Hypoxia

2001 • 333 citations

Host Prostaglandin E2-EP3 Signaling Regulates Tumor-Associated Angiogenesis and Tumor Growth

2003 • 330 citations

Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis.

1998 • 311 citations

Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway

2000 • 299 citations

Vascular Apoptosis and Involution in Gliomas Precede Neovascularization: A Novel Concept for Glioma Growth and Angiogenesis

2000 • 291 citations

Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2

2001 • 289 citations

The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression

1996 • 287 citations

NSAIDs inhibit αVβ3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis

2001 • 280 citations

Hypoxia Regulates Expression of the Endothelin-1 Gene through a Proximal Hypoxia-Inducible Factor-1 Binding Site on the Antisense Strand

1998 • 267 citations

Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

1999 • 243 citations

Adrenomedullin Gene Expression Is Developmentally Regulated and Induced by Hypoxia in Rat Ventricular Cardiac Myocytes

1998 • 233 citations

Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2

2002 • 222 citations

Cyclooxygenase-2: a therapeutic target in angiogenesis

2003 • 203 citations

Vascular Endothelial Growth Factor and Angiopoietins in Focal Cerebral Ischemia

2002 • 194 citations

PGE2 Stimulates VEGF Expression in Endothelial Cells via ERK2/JNK1 Signaling Pathways

2001 • 192 citations

Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2

2002 • 173 citations

Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization

2000 • 167 citations

Mechanisms of Hypoxia-induced Endothelial Cell Death

1999 • 153 citations

Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia

1993 • 152 citations

Up-regulation of Apoptosis Inhibitory Protein IAP-2 by Hypoxia

2001 • 147 citations

Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn

2002 • 131 citations

Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia

2002 • 127 citations

Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells

2002 • 125 citations

Sp1 Increases Expression of Cyclooxygenase-2 in Hypoxic Vascular Endothelium

2000 • 111 citations

Hypoxia-Inducible Angiopoietin-2 Expression Is Mimicked by Iodonium Compounds and Occurs in the Rat Brain and Skin in Response to Systemic Hypoxia and Tissue Ischemia

2000 • 103 citations

Angiotensin II Induces Expression of the Tie2 Receptor Ligand, Angiopoietin-2, in Bovine Retinal Endothelial Cells

2001 • 101 citations

Tumor Necrosis Factor-α Upregulates Angiopoietin-2 in Human Umbilical Vein Endothelial Cells

2000 • 100 citations

Hypoxia and vascular endothelial growth factor acutely up-regulate angiopoietin-1 and Tie2 mRNA in bovine retinal pericytes

2003 • 90 citations

Characterization and Expression of a Novel Alternatively Spliced Human Angiopoietin-2

2000 • 66 citations

Hypoxic up-regulation of erythroid 5-aminolevulinate synthase

2002 • 64 citations

Biomedical significance of endothelial cell specific growth factor, angiopoietin

2002 • 61 citations

Prostaglandin-mediated inhibition of nitric oxide production by bovine aortic endothelium during hypoxia

1995 • 36 citations

Genomic Structure and Alternative Splicing of Chicken Angiopoietin-2

2000 • 17 citations