Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Vascular-specific growth factors and blood vessel formation

2000 • 3,667 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

1999 • 2,176 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Molecular and biological properties of vascular endothelial growth factor

1999 • 1,174 citations

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

1992 • 1,103 citations

TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION

1972 • 898 citations

New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF

1999 • 751 citations

Regulation of angiogenesis via vascular endothelial growth factor receptors.

2000 • 749 citations

Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.

1995 • 598 citations

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

1993 • 502 citations

Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

1998 • 491 citations

Tie receptors: new modulators of angiogenic and lymphangiogenic responses

2001 • 412 citations

Initial Stages of Tumor Cell-Induced Angiogenesis: Evaluation Via Skin Window Chambers in Rodent Models

2000 • 329 citations

Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium.

1994 • 315 citations

Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis.

1998 • 311 citations

Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway

2000 • 299 citations

Microvascular ischemia-reperfusion injury in striated muscle: significance of "reflow paradox"

1992 • 270 citations

Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases.

2001 • 269 citations

Expressions ofPDGF receptor alpha, c‐KitandFlk1genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells

1997 • 224 citations

In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis

1999 • 222 citations

Determinants of human astrocytoma migration.

1994 • 204 citations

Expressional Regulation of Angiopoietin-1 and -2 and the Tie-1 and -2 Receptor Tyrosine Kinases during Cutaneous Wound Healing: A Comparative Study of Normal and Impaired Repair

2001 • 162 citations

Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis.

2001 • 147 citations

Invasion of experimental rat brain tumor: early morphological changes following microinjection of C6 glioma cells

1993 • 140 citations

Characterization of Angiogenesis and Microcirculation of High–Grade Glioma: An Intravital Multifluorescence Microscopic Approach in the Athymic Nude Mouse

1998 • 116 citations

Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma.

1996 • 108 citations

Intravital Fluorescence Videomicroscopy to Study Tumor Angiogenesis and Microcirculation

2000 • 105 citations

C6 glioma cell invasion and migration of rat brain after neural homografting

1990 • 85 citations

C6 Glioma Cell Invasion and Migration of Rat Brain after Neural Homografting: Ultrastructure

1990 • 76 citations

The biology of malignant gliomas--a comprehensive survey.

1984 • 73 citations

Glioma cell migration is associated with glioma‐induced angiogenesis in vivo

1999 • 45 citations

Vascularization of human glioma spheroids implanted into rat cortex is conferred by two distinct mechanisms

1999 • 43 citations

Tumor endothelium-specific transgene expression directed by vascular endothelial growth factor receptor-2 (Flk-1) promoter/enhancer sequences.

2000 • 37 citations

Vascular Endothelial Growth Factor-driven Glioma Growth and Vascularization in an Orthotopic Rat Model Monitored by Magnetic Resonance Imaging

2000 • 34 citations

In situ Hybridization with RNA Probes

2003 • 15 citations