Vascular Apoptosis and Involution in Gliomas Precede Neovascularization: A Novel Concept for Glioma Growth and Angiogenesis

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

mouse brain in stereotaxic coordinates

1997 • 3,077 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

1999 • 2,176 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

1995 • 1,171 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

Integrins and anoikis

1997 • 1,145 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Increased Vascularization in Mice Overexpressing Angiopoietin-1

1998 • 818 citations

Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea 2

1974 • 762 citations

Glioblastoma multiforme and anaplastic astrocytoma pathologic criteria and prognostic implications

1985 • 659 citations

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

1993 • 643 citations

Vascular Endothelial Growth Factor (VEGF)-Mediated Angiogenesis Is Associated with Enhanced Endothelial Cell Survival and Induction of Bcl-2 Expression

1999 • 638 citations

Integrin transmembrane signaling and cytoskeletal control

1995 • 616 citations

Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

1997 • 512 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells

1997 • 477 citations

Angiopoietin-1 induces sprouting angiogenesis in vitro

1998 • 467 citations

Apoptosis of Vascular Smooth Muscle Cells Induced by In Vitro Stimulation With Interferon-γ, Tumor Necrosis Factor–α, and Interleukin-1β

1996 • 435 citations

Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.

1999 • 418 citations

Vasculogenesis, Angiogenesis, and Growth Factors: Ephrins Enter the Fray at the Border

1998 • 389 citations

Alternative forms of rat TrkC with different functional capabilities

1993 • 374 citations

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

1996 • 371 citations

Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro.

1991 • 358 citations

Regulation of Tenascin-C, a Vascular Smooth Muscle Cell Survival Factor that Interacts with the αvβ3 Integrin to Promote Epidermal Growth Factor Receptor Phosphorylation and Growth

1997 • 341 citations

Cell death by apoptosis during involution of the lactating breast in mice and rats

1989 • 341 citations

Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis.

1997 • 330 citations

Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis.

1998 • 311 citations

Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression.

1997 • 284 citations

Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells.

1996 • 265 citations

Apoptosis induced by inhibition of intercellular contact.

1994 • 256 citations

Angiopoietin‐1 is an apoptosis survival factor for endothelial cells

1999 • 242 citations

Demonstration and characterization of the angiogenic properties of cervical dysplasia.

1994 • 234 citations

In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis

1999 • 222 citations

Fas ligation triggers apoptosis in macrophages but not endothelial cells

1994 • 192 citations

Reactive oxygen species induce apoptosis of vascular smooth muscle cell

1997 • 188 citations

Smooth Muscle Apoptosis During Vascular Regression in Spontaneously Hypertensive Rats

1997 • 171 citations

Mechanisms of Hypoxia-induced Endothelial Cell Death

1999 • 153 citations

Vascular Cell Apoptosis

1999 • 149 citations

Cell death and cell proliferation during atrophy of the rat parotid gland induced by duct obstruction

1987 • 147 citations

The Protective Role of Glutathione Peroxidase in Apoptosis Induced by Reactive Oxygen Species

1996 • 147 citations

Integrin Signaling and Matrix Assembly

1996 • 144 citations

Mechanism of deletion of endothelial cells during regression of the corpus luteum.

1984 • 143 citations

Invasion of experimental rat brain tumor: early morphological changes following microinjection of C6 glioma cells

1993 • 140 citations

A relationship between apoptosis and flow during programmed capillary regression is revealed by vital analysis

1996 • 139 citations

Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro.

1996 • 136 citations

Cyclic angiogenesis and blood vessel regression in the ovary: blood vessel regression during luteolysis involves endothelial cell detachment and vessel occlusion.

1996 • 136 citations

Second Place — Resident Clinical Science Award 1994: Tumor Angiogenesis, the P53 Antigen, and Cervical Metastasis in Squamous Cell Carcinoma of the Tongue

1994 • 133 citations

17β-Estradiol Inhibits Apoptosis of Endothelial Cells

1997 • 119 citations

The microvascular extracellular matrix. Developmental changes during angiogenesis in the aortic ring-plasma clot model.

1987 • 118 citations

Regression of vessels in the tunica vasculosa lentis is initiated by coordinated endothelial apoptosis: A role for vascular endothelial growth factor as a survival factor for endothelium

1998 • 118 citations

Release of Cytochrome c, Bax Migration, Bid Cleavage, and Activation of Caspases 2, 3, 6, 7, 8, and 9 during Endothelial Cell Apoptosis

1999 • 106 citations

Antisense Inhibition of Basic Fibroblast Growth Factor Induces Apoptosis in Vascular Smooth Muscle Cells

1996 • 105 citations

Apoptosis of vascular smooth muscle cells in atherosclerosis

1998 • 94 citations

Angiogenic growth factors in neural embryogenesis and neoplasia.

1995 • 94 citations

Role of Apoptosis in Biology and Pathology: Resistance to Apoptosis in Colon Carcinogenesis

1995 • 91 citations

Induction of Endothelial Cell Apoptosis by Solid Tumor Cells

1998 • 86 citations

Early Effects of Castration on the Vascular System of the Rat Ventral Prostate Gland*

1999 • 81 citations

Necrogenesis and Fas/APO-1 (CD95) Expression in Primary (de novo) and Secondary Glioblastomas

1998 • 77 citations

Interactions between newly formed endothelial channels and carcinoma cells in plasma clot culture

1986 • 72 citations

Angiogenesis-dependent tumor spread in reinforced fibrin clot culture.

1983 • 69 citations

Expression and modulation of major histocompatibility antigens on murine primary brain tumor in vitro

1991 • 64 citations

Long-Term, Stable Expression of Green Fluorescent Protein in Mammalian Cells

1997 • 58 citations

Endothelial growth factor present in tissue culture of CNS tumors

1976 • 50 citations

The blood-brain barrier in primary CNS lymphomas: Ultrastructural evidence of endothelial cell death

1999 • 42 citations

Redistribution of Cytochrome c Precedes the Caspase-Dependent Formation of Ultracondensed Mitochondria, with a Reduced Inner Membrane Potential, in Apoptotic Monocytes

1999 • 35 citations

Morphologic and temporal analysis of vascular smooth muscle cell apoptosis induced by c‐Myc and E1A

1998 • 14 citations

Ultrastructure of blood vessel regression in involution of foreign-body granuloma.

1998 • 4 citations