PKC-ε Is Required for Mechano-sensitive Activation of ERK1/2 in Endothelial Cells

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.

1985 • 2,605 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells

1994 • 520 citations

Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.

1993 • 358 citations

Lipid second messengers

1994 • 357 citations

Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells

1992 • 355 citations

Function follows form: generation of intracellular signals by cell deformation

1991 • 345 citations

Role of Diacylglycerol-Regulated Protein Kinase C Isotypes in Growth Factor Activation of the Raf-1 Protein Kinase

1997 • 292 citations

Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters.

1994 • 289 citations

Fluid Shear Stress Stimulates Mitogen-Activated Protein Kinase in Endothelial Cells

1995 • 287 citations

Differential Effect of Shear Stress on Extracellular Signal-regulated Kinase and N-terminal Jun Kinase in Endothelial Cells

1997 • 269 citations

Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function.

1996 • 252 citations

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides.

1994 • 242 citations

The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

1996 • 234 citations

MAP Kinase Activation by Flow in Endothelial Cells

1996 • 224 citations

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

1993 • 222 citations

Protein Kinase C-ζ Mediates Angiotensin II Activation of ERK1/2 in Vascular Smooth Muscle Cells

1997 • 220 citations

Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase.

1996 • 217 citations

Shear stress increases inositol trisphosphate levels in human endothelial cells

1990 • 215 citations

Pulsatile and steady flow induces c‐fos expression in human endothelial cells

1993 • 203 citations

Flow-induced calcium transients in single endothelial cells: spatial and temporal analysis

1992 • 184 citations

Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase.

1996 • 168 citations

A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

1993 • 161 citations

Protein kinases as mediators of fluid shear stress stimulated signal transduction in endothelial cells: A hypothesis for calcium-dependent and calcium-independent events activated by flow

1995 • 158 citations

Proton conductance of the plasma membrane: properties, regulation, and functional role

1993 • 136 citations

The Cloned Thrombin Receptor Is Necessary and Sufficient for Activation of Mitogen-activated Protein Kinase and Mitogenesis in Mouse Lung Fibroblasts

1996 • 127 citations

Immunological evidence for two physiological forms of protein kinase C.

1987 • 104 citations

Epsilon-isoenzyme of protein kinase C induces a Ca(2+)-independent contraction in vascular smooth muscle

1996 • 102 citations

Histamine Antagonizes Serotonin and Growth Factor-induced Mitogen-activated Protein Kinase Activation in Bovine Tracheal Smooth Muscle Cells

1995 • 68 citations

Angiotensin II Stimulates MAP Kinase Kinase Kinase Activity in Vascular Smooth Muscle Cells

1996 • 67 citations

Evidence That the Bradykinin-induced Activation of Phospholipase D and of the Mitogen-activated Protein Kinase Cascade Involve Different Protein Kinase C Isoforms

1995 • 52 citations

Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells.

1996 • 41 citations

Angiotensin II type 1 receptor signals through Raf-1 by a protein kinase C-dependent, Ras-independent mechanism.

1996 • 40 citations

Activation of mitogen‐activated protein kinase by protein kinase C isotypes α, β_I and γ, but not ϵ

1996 • 22 citations

Efficacy of agonist-stimulated MEK activation determines the susceptibility of mitogen-activated protein (MAP) kinase to inhibition in rat aortic smooth muscle cells

1996 • 20 citations

PKC α regulates thrombin‐induced PDGF‐B chain gene expression in mesangial cells

1995 • 19 citations