Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved.

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Chelerythrine is a potent and specific inhibitor of protein kinase C

1990 • 1,208 citations

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

1993 • 1,005 citations

Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia.

1993 • 629 citations

Preconditioning protects ischemic rabbit heart by protein kinase C activation

1994 • 603 citations

Role of Bradykinin in Protection of Ischemic Preconditioning in Rabbit Hearts

1995 • 524 citations

Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms ε and η in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity

1997 • 491 citations

Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C

1995 • 424 citations

Protein kinase C. Its role in ischemic preconditioning in the rat.

1994 • 362 citations

The Protective Effect of Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Mediated by Nitric Oxide Synthase

1997 • 316 citations

Evidence that Translocation of Protein Kinase C is a Key Event During Ischemic Preconditioning of Rabbit Myocardium

1994 • 310 citations

Does Ischemic Preconditioning in the Human Involve Protein Kinase C and the ATP-Dependent K ⁺ Channel?

1995 • 293 citations

Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning.

1994 • 272 citations

alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.

1994 • 258 citations

Evidence That Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Triggered by the Generation of Nitric Oxide

1997 • 255 citations

Nitric Oxide Synthase Is the Mediator of Late Preconditioning Against Myocardial Infarction in Conscious Rabbits

1998 • 254 citations

Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs.

1996 • 244 citations

Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs.

1995 • 238 citations

Characterisation of the infarct-limiting effect of delayed preconditioning: timecourse and dose-dependency studies in rabbit myocardium

1997 • 214 citations

Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts

1995 • 180 citations

Conscious rabbits become tolerant to multiple episodes of ischemic preconditioning.

1994 • 163 citations

Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium

1995 • 161 citations

Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor

1994 • 158 citations

Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits

1997 • 151 citations

Protein kinase C isoform diversity in the heart

1995 • 146 citations

Alpha 1-receptor-independent activation of protein kinase C in acute myocardial ischemia. Mechanisms for sensitization of the adenylyl cyclase system.

1992 • 144 citations

Molecular Genetic Analysis of the Regulatory and Catalytic Domains of Protein Kinase C

1989 • 138 citations

Time Course of Late Preconditioning Against Myocardial Stunning in Conscious Pigs

1996 • 132 citations

Does Ischemic Preconditioning Trigger Translocation of Protein Kinase C in the Canine Model?

1995 • 122 citations

Role of Activation of Protein Kinase C in the Infarct SizeLimiting Effect of Ischemic Preconditioning Through Activation of Ecto-5′-nucleotidase

1996 • 122 citations

Postischemic myocardial "stunning". Identification of major differences between the open-chest and the conscious dog and evaluation of the oxygen radical hypothesis in the conscious dog.

1991 • 109 citations

Demonstration of free radical generation in the "stunned" myocardium in the conscious dog and identification of major differences between conscious and open-chest dogs.

1993 • 109 citations

Infarct limitation of the second window of protection in a conscious rabbit model

1996 • 108 citations

No Prevention of Ischemic Preconditioning by the Protein Kinase C Inhibitor Staurosporine in Swine

1996 • 103 citations

Protection of Ischemic Preconditioning is Dependent upon a Critical Timing Sequence of Protein Kinase C Activation

1997 • 87 citations

Does protein kinase C play a role in ischemic preconditioning in rat hearts?

1995 • 79 citations

Role of bradykinin in cardiac functional protection after global ischemia-reperfusion in rat heart

1995 • 78 citations

Anaesthetics alter the magnitude of infarct limitation by ischaemic preconditioning

1994 • 74 citations

Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits

1995 • 68 citations

Preconditioning of isolated rabbit cardiomyocytes: effects of glycolytic blockade, phorbol esters, and ischaemia

1994 • 61 citations

Role of adenosine receptors in late preconditioning against myocardial stunning in conscious rabbits

1997 • 60 citations

Limitation of myocardial infarct size by adenosine A1 receptor activation is abolished by protein kinase C inhibitors in the rabbit

1995 • 58 citations

Infarct limitation of the second window of protection in a conscious rabbit model

1996 • 54 citations

Translocation of PKC, Protein Phosphatase Inhibition and Preconditioning of Rabbit Cardiomyocytes

1996 • 51 citations

Myocardial Adaptation, Stress Proteins, and the Second Window of Protection

1996 • 44 citations

Preconditioning During Ischemia

1995 • 37 citations

Premedication with the opioid analgesic butorphanol raises the threshold for ischemic preconditioning in dogs

1997 • 34 citations

Direct evidence that ischemic preconditioning does not cause protein kinase C translocation in rabbit heart

1996 • 29 citations

α-Adrenergic Preservation of Myocardial pH during Ischemia Is PKC Isoform Dependent

1996 • 16 citations

Premedication with the opioid analgesic butorphanol raises the threshold for ischemic preconditioning in dogs

1997 • 1 citations