Synthesis of diacylglycerol de novo is responsible for permanent activation and down-regulation of protein kinase C in transformed cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1987 • 330 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Insulin Rapidly Increases Diacylglycerol by Activating De Novo Phosphatidic Acid Synthesis

1987 • 200 citations

Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets.

1988 • 173 citations

Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.

1988 • 143 citations

Rapid Stimulation of Diacylglycerol Production in Xenopus Oocytes by Microinjection of H- ras p21

1987 • 134 citations

Down-regulation of protein kinase C and of an endogenous 80-kDa substrate in transformed fibroblasts.

1987 • 119 citations

Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown.

1989 • 106 citations

Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis.

1989 • 103 citations

Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed rat fibroblasts.

1988 • 94 citations

p21H-ras-induced morphological transformation and increases in c-myc expression are independent of functional protein kinase C.

1989 • 85 citations

Insulin and glucose modulate protein kinase C activity in rat adipocytes

1988 • 80 citations

Partial down-regulation of protein kinase C in C3H 10T 1/2 mouse fibroblasts transfected with the human Ha-ras oncogene.

1988 • 63 citations

Altered signal transduction in erbB-transformed cells. Implication of enhanced inositol phospholipid metabolism in erbB-induced transformation.

1987 • 62 citations

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems.

1988 • 53 citations

Oncogenes and growth control 1987

1987 • 50 citations

Glucose‐induced synthesis of diacylglycerol de novo is associated with translocation (activation) of protein kinase C in rat adipocytes

1989 • 47 citations

Reduced protein kinase C activity in a ras-resistant cell line derived from Ki-MSV transformed cells.

1987 • 43 citations

Transformation of balb3T3 cells with EJ/T24/H-Ras oncogene inhibits adenylate cyclase response to β-adrenergic agonist while increases muscarinic receptor dependent hydrolysis of inositol lipids

1985 • 39 citations

Metabolic effects of 2-deoxy-D-glucose in isolated fat cells

1977 • 35 citations

Point-mutated P21 couples a muscarinic receptor to calcium channels and polyphosphoinositide hydrolysis

1986 • 34 citations

NIH3T3 fibroblasts transformed by the dbl oncogene show altered expression of bradykinin receptors: effect on inositol lipid turnover.

1989 • 31 citations

Oncogenes, protein kinase C, neuronal differentiation and memory

1989 • 27 citations

Elevation of 1,2-diacylglycerol in ras-transformed neonatal liver and pancreas of transgenic mice.

1989 • 21 citations

Polyphosphoinositide metabolism is rapidly stimulated by activation of a temperature-sensitive mutant of Rous sarcoma virus in rat fibroblasts.

1987 • 19 citations

Inhibition of the amplified bombesin‐stimulated inositol phosphate response in N‐ras transformed cells by high density culturing

1988 • 11 citations