Role of Protein Kinase C in Intracellular Signaling

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

The smooth muscle cell in culture

1979 • 1,546 citations

Atherosclerosis and the Arterial Smooth Muscle Cell

1973 • 1,503 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

Replication of smooth muscle cells in vascular disease.

1986 • 770 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

The Calcium Messenger System

1986 • 669 citations

The Role of Protein Kinase C in Transmembrane Signalling

1986 • 557 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

Identification of intracellular receptor proteins for activated protein kinase C.

1991 • 505 citations

Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.

1986 • 491 citations

Limited Proteolysis of Protein Kinase C Subspecies by Calcium-dependent Neutral Protease (Calpain)

1989 • 470 citations

The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase

1991 • 454 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.

1988 • 430 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

What controls smooth muscle phenotype?

1981 • 322 citations

Expression and Properties of Two Types of Protein Kinase C: Alternative Splicing from a Single Gene

1987 • 317 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.

1992 • 300 citations

Effect of phorbol esters on protein kinase C-zeta.

1992 • 282 citations

A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor.

1993 • 277 citations

The Calcium Messenger System

1986 • 275 citations

Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

1993 • 272 citations

Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase

1993 • 270 citations

A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

1990 • 257 citations

Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C

1985 • 255 citations

Protein kinase C contains two phorbol ester binding domains.

1991 • 234 citations

Inositol trisphosphate receptor: phosphorylation by protein kinase C and calcium calmodulin-dependent protein kinases in reconstituted lipid vesicles.

1991 • 233 citations

Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells

1989 • 230 citations

Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells.

1989 • 221 citations

Inositides and the nucleus and inositides in the nucleus

1993 • 209 citations

Regulation of phospholipase C by G proteins

1992 • 205 citations

Ca(2+)-independent isoforms of protein kinase C differentially translocate in smooth muscle

1992 • 185 citations

Protein kinase C and T cell activation

1990 • 183 citations

Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol

1993 • 182 citations

Overexpression of Protein Kinase C in HT29 Colon Cancer Cells Causes Growth Inhibition and Tumor Suppression

1990 • 179 citations

Biochemical characterization of rat brain protein kinase C isozymes.

1988 • 178 citations

Intracellular calcium levels in phorbol ester-induced contractions of vascular muscle

1987 • 170 citations

Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family.

1987 • 156 citations

Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.

1992 • 146 citations

Ca2+-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells.

1989 • 138 citations

Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.

1991 • 129 citations

Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.

1987 • 126 citations

Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas.

1991 • 117 citations

Differentiation of Vascular Smooth Muscle Cells and the Regulation of Protein Kinase C-α

1995 • 112 citations

Protein kinase C translocation in intact vascular smooth muscle strips

1990 • 112 citations

Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression.

1990 • 112 citations

Regulation of one type of Ca ²⁺ current in smooth muscle cells by diacylglycerol and acetylcholine

1988 • 106 citations

Possible involvement of protein kinase C in platelet-derived growth factor-stimulated DNA synthesis in vascular smooth muscle cells

1987 • 106 citations

Deletion of the regulatory domain of protein kinase C alpha exposes regions in the hinge and catalytic domains that mediate nuclear targeting.

1992 • 104 citations

Phosphorylation of the purified receptor for calcium channel blockers by cAMP kinase and protein kinase C

1987 • 103 citations

[Ca2+]-dependent myosin phosphorylation in phorbol diester stimulated smooth muscle contraction

1988 • 99 citations

Activation of resting human T cells requires prolonged stimulation of protein kinase C.

1990 • 99 citations

Complete Activation of Protein Kinase C by an Antipeptide Antibody Directed against the Pseudosubstrate Prototope

1989 • 94 citations

Phorbol ester contracts rabbit thoracic aorta by increasing intracellular calcium and by activating calcium influx

1986 • 91 citations

Phenylephrine‐induced translocation of protein kinase C and shortening of two types of vascular cells of the ferret.

1992 • 76 citations

Phospholipids in the nucleus—metabolism and possible functions

1992 • 75 citations

Platelet-derived growth factor and angiotensin II induce different spatial distribution of protein kinase C-alpha and -beta in vascular smooth muscle cells.

1994 • 71 citations

Failure of wild-type or a mutant form of protein kinase C-α to transform fibroblasts

1991 • 68 citations

Differential Expression and Subcellular Localization of Protein Kinase C α, β, γ, δ, and ɛ Isoforms in SH‐SY5Y Neuroblastoma Cells: Modifications During Differentiation

1993 • 68 citations

Protein kinase C down-regulation, and not transient activation, correlates with melanocyte growth.

1991 • 62 citations

Phorbol dibutyrate contractions in rabbit aorta: calcium dependence and sensitivity to nitrovasodilators and 8-BR-cyclic GMP.

1986 • 57 citations

Protein kinase C beta gene expression is associated with susceptibility of human promyelocytic leukemia cells to phorbol ester-induced differentiation.

1992 • 56 citations

Measurement of phorbol ester receptors in intact cells and subcellular fractions

1987 • 51 citations

Distinct functions of down‐regulation‐sensitive and ‐resistant types of protein kinase C in rabbit aortic smooth muscle cells

1987 • 47 citations

Mitogen-stimulated phosphorylation of nuclear proteins in Swiss 3T3 cells: Evidence for a protein kinase C requirement

1989 • 39 citations

Protein Kinase C-Dependent Phosphorylation of Sarcolemmal Ca2+-ATPase Isolated from Bovine Aortic Smooth Muscle1

1990 • 28 citations

Cell cycle phase‐dependent effect of retinoic acid on the induction of granulocytic differentiation in HL‐60 promyelocytic leukemia cells

1993 • 28 citations

Retinoic Acid-Specific Induction of a Protein Kinase C Isoform during Differentiation of HL-60 Cells1

1992 • 20 citations

Trans-retinoic acid and related differentiation agents.

1992 • 19 citations

Selective Increase of the α Subspecies of Protein Kinase C and Inhibition of Melanogenesis Induced by Retinoic Acid in Melanoma Cells

1993 • 17 citations

Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation

1993 • 16 citations

Increased Protein Kinase C Activity in Human Memory T Cells

1993 • 16 citations

Activation of protein kinase C induces differentiation in the human T-lymphoblastic cell line MOLT-3

1989 • 12 citations

Enhancement of protein kinase C in murine lymphokine-activated killer cells by retinoic acid.

1992 • 11 citations

Membrane phospholipid turnover in signal transduction.

1985 • 7 citations

Inositol Trisphosphate and Diacylglycerol as Intracellular Second Messengers

1985 • 6 citations

Enhancement of Perforin by Retinoic Acid Is Mediated by Protein Kinase C

1993 • 4 citations

The Protein Kinase C Family

1990 • 4 citations

Selective Increase of the α Subspecies of Protein Kinase C and Inhibition of Melanogenesis Induced by Retinoic Acid in Melanoma Cells

1993 • 4 citations