The Receptor Concept: A Continuing Evolution

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

G Protein-coupled Receptors

1998 • 1,292 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

G Protein Pathways

2002 • 1,222 citations

G-protein-coupled receptor heterodimerization modulates receptor function

1999 • 1,146 citations

A MODIFICATION OF RECEPTOR THEORY

1956 • 1,126 citations

The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

2002 • 1,070 citations

FRACTIONATION AND CHARACTERIZATION OF A CYCLIC ADENINE RIBONUCLEOTIDE FORMED BY TISSUE PARTICLES

1958 • 1,055 citations

G Protein-Coupled Receptor Allosterism and Complexing

2002 • 910 citations

Molecular Structure and Physiological Functions of GABA_BReceptors

2004 • 861 citations

Signal transduction and endocytosis: close encounters of many kinds

2002 • 820 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*

1967 • 682 citations

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor

1999 • 673 citations

Agonist-receptor efficacy II: agonist trafficking of receptor signals

1995 • 637 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

THE ACTION OF CERTAIN ESTERS AND ETHERS OF CHOLINE, AND THEIR RELATION TO MUSCARINE

1914 • 604 citations

Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors.

1977 • 544 citations

α-Adrenoceptor subclassification

1981 • 492 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 469 citations

GTP-binding proteins in membranes and the control of adenylate cyclase activity.

1977 • 456 citations

Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization

2003 • 440 citations

Principles: Receptor theory in pharmacology

2004 • 406 citations

Historical review: A brief history and personal retrospective of seven-transmembrane receptors

2004 • 403 citations

Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

2003 • 397 citations

Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites.

1975 • 381 citations

Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.

1978 • 372 citations

Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor

2001 • 361 citations

Direct evidence for a β1-adrenergic receptor–directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy

2004 • 344 citations

Signal sorting and amplification through G protein-coupled receptors

1989 • 338 citations

Ligand-selective receptor conformations revisited: the promise and the problem

2003 • 319 citations

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.

1976 • 318 citations

Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides.

1976 • 314 citations

Gene targeting — homing in on α2-adrenoceptor-subtype function

1997 • 308 citations

ACTH Receptors in the Adrenal: Specific Binding of ACTH- ¹²⁵ I and Its Relation to Adenyl Cyclase

1970 • 303 citations

Distinct α-noradrenergic receptors differentiated by binding and physiological relationships

1979 • 300 citations

Resolution of some components of adenylate cyclase necessary for catalytic activity.

1977 • 283 citations

G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction

2002 • 263 citations

Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion.

1976 • 240 citations

Receptor Occupancy and Tissue Response

1956 • 238 citations

The reaction between acetyl choline and muscle cells

1926 • 230 citations

Stereospecific [3H](−)-alprenolol binding sites, β-adrenergic receptors and adenylate cyclase

1974 • 229 citations

Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system.

1980 • 229 citations

β-Adrenergic Receptor: Stereospecific Interaction of Iodinated β-Blocking Agent with High Affinity Site

1974 • 229 citations

In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors.

2000 • 208 citations

Mammalian .beta.2-adrenergic receptor: purification and characterization

1984 • 207 citations

Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor.

1996 • 188 citations

Modeling the Functional Effects of Allosteric Modulators at Pharmacological Receptors: An Extension of the Two-State Model of Receptor Activation

2000 • 188 citations

Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway

2003 • 163 citations

Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.

1992 • 157 citations

Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography.

1977 • 156 citations

Catecholamine-Induced Alteration in Sedimentation Behavior of Membrane Bound β-Adrenergic Receptors

1980 • 153 citations

The Binding Characteristics and Number of β-Adrenergic Receptors on the Turkey Erythrocyte

1974 • 151 citations

Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors

2004 • 146 citations

Prazosin: differential affinities for two populations of α-noradrenergic receptor binding sites

1978 • 134 citations

Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide.

1982 • 132 citations

Localization and trafficking of α2-adrenergic receptor subtypes in cells and tissues

1999 • 127 citations

Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation

2004 • 112 citations

Oligomerization of NHERF-1 and NHERF-2 PDZ Domains: Differential Regulation by Association with Receptor Carboxyl-Termini and by Phosphorylation

2001 • 108 citations

The non-stoichiometric floating receptor model for hormone sensitive adenylyl cyclase

1976 • 106 citations

Isolation of adenylate cyclase-free, beta-adrenergic receptor from turkey erythrocyte membranes by affinity chromatography.

1977 • 104 citations

Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.

2001 • 99 citations

Synergistic Contributions of the Functional Groups of Epinephrine to Its Affinity and Efficacy at the β₂Adrenergic Receptor

2004 • 86 citations

A Fraction of the Ventricular Myocardium That Has the Specificity of the Cardiac Beta-Adrenergic Receptor

1971 • 78 citations

Kinetics of interaction between beta-receptors, GTP protein, and the catalytic unit of turkey erythrocyte adenylate cyclase.

1982 • 76 citations

INSIGHTS FROM IN VIVO MODIFICATION OF ADRENERGIC RECEPTOR GENE EXPRESSION

1998 • 74 citations

Mutations in G protein-linked receptors: Novel insights on disease

1993 • 73 citations

Accessory Proteins for G Protein-Signaling Systems: Activators of G Protein Signaling and Other Nonreceptor Proteins Influencing the Activation State of G Proteins

2003 • 37 citations

The Ternary Complex Model

2000 • 24 citations

The Immunology of the Insulin Receptor

1976 • 13 citations

Complexity in biological systems

1999 • 13 citations