Gene targeting — homing in on α2-adrenoceptor-subtype function

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

1996 • 895 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

Embryonic stem cells alone are able to support fetal development in the mouse

1990 • 789 citations

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

1995 • 740 citations

The new mouse genetics: Altering the genome by gene targeting

1989 • 608 citations

Central Hypotensive Effects of the α _2a -Adrenergic Receptor Subtype

1996 • 484 citations

Cardiovascular Regulation in Mice Lacking α ₂ -Adrenergic Receptor Subtypes b and c

1996 • 463 citations

Distributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization study

1993 • 458 citations

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

1988 • 440 citations

Distribution of α2-adrenergic receptor subtype gene expression in rat brain

1994 • 423 citations

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor

1995 • 408 citations

Distribution of ?2C-adrenergic receptor-like immunoreactivity in the rat central nervous system

1996 • 351 citations

Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.

1996 • 302 citations

The distribution and significance of CNS adrenoceptors examined with in situ hybridization

1996 • 298 citations

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.

1990 • 287 citations

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

1995 • 285 citations

Perikaryal and synaptic localization ofα2A-adrenergic receptor-like immunoreactivity

1994 • 214 citations

Distribution of ?2A-adrenergic receptor-like immunoreactivity in the rat central nervous system

1996 • 208 citations

Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization

1994 • 196 citations

In vivo studies with antisense oligonucleotides

1997 • 193 citations

Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain.

1987 • 185 citations

Expression of multiple alpha adrenergic receptor subtype messenger RNAs in the adult rat brain

1993 • 180 citations

Immunohistochemical localization ofα2a-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat

1993 • 175 citations

Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology

1995 • 170 citations

Genetic Alteration of α_2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α₂-Adrenoceptor Agonist

1997 • 165 citations

A Point Mutation of the α ₂ -Adrenoceptor that Blocks Coupling to Potassium but not Calcium Currents

1992 • 160 citations

Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding.

1992 • 160 citations

Molecular characterization of α1- and α2-adrenoceptors

1991 • 153 citations

Distribution and pharmacology of alpha 2-adrenoceptors in the central nervous system.

1995 • 144 citations

Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.

1990 • 117 citations

Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog.

1995 • 116 citations

Characterization of the alpha-2C adrenergic receptor subtype in the opossum kidney and in the OK cell line.

1991 • 116 citations

Alpha2A-adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating spinal cord

1994 • 113 citations

Expression of α2 adrenoceptors during rat brain development—I. α2A messenger RNA expression

1996 • 112 citations

EXPRESSION OF α 2 -ADRENERGIC RECEPTOR SUBTYPES IN THE MOUSE BRAIN: EVALUATION OF SPATIAL AND TEMPORAL INFORMATION IMPARTED BY 3 kb OF 5′ REGULATORY SEQUENCE FOR THE α 2A AR-RECEPTOR GENE IN TRANSGENIC ANIMALS

1996 • 110 citations

α2-Adrenoceptors: more subtypes but fewer functional differences

1994 • 99 citations

The Three α2-Adrenergic Receptor Subtypes Achieve Basolateral Localization in Madin-Darby Canine Kidney II Cells via Different Targeting Mechanisms

1996 • 96 citations

Expression of α2 adrenoceptors during rat brain development—II. α2C messenger RNA expression and [3H]rauwolscine binding

1996 • 95 citations

Medetomidine stereoisomers delineate two closely related subtypes of idazoxan (imidazoline) I-receptors in the guinea pig

1991 • 82 citations

Coupling of human α2-adrenoceptor subtypes to regulation of cAMP production in transfected S115 cells

1994 • 74 citations

Use of recombinant human α2-adrenoceptors to characterize subtype selectivity of antagonist binding

1993 • 67 citations

Putting the 'A' in atypical: does α2-adrenoceptor antagonism account for the therapeutic advantage of new antipsychotics?

1994 • 58 citations

Differential localization of α2-adrenergic receptor subtypes in brain

1992 • 55 citations

α2-Adrenoceptors and I2 sites in the mammalian central nervous system

1995 • 51 citations

Cold‐induced potentiation of α₂‐adrenergic vasoconstriction in primary raynaud's disease

1993 • 50 citations

Antisense knockouts: molecular scalpels for the dissection of signal transduction

1994 • 50 citations

Cloning and expression of the alpha 2C-adrenergic receptor from the OK cell line.

1994 • 49 citations

Brimonidine in the Prevention of Intraocular Pressure Elevation Following Argon Laser Trabeculoplasty

1993 • 46 citations

Adrenergic and Imidazoline Receptor‐Mediated Responses to UK‐14,304‐18 (Brimonidine) in Rabbits and Monkeys

1995 • 45 citations

Cloning and expression of a fish α₂‐adrenoceptor

1993 • 41 citations

Transcriptional Regulation: : Converting an activator into a repressor

1995 • 37 citations

Genetic evidence for involvement of multiple effector systems in alpha 2A-adrenergic receptor inhibition of stimulus-secretion coupling.

1996 • 31 citations

Molecular determinants of the alpha-2D adrenergic receptor subtype

1993 • 29 citations

Subclassification of presynaptic ?2-adrenoceptors: ?2D-autoreceptors and ?2D-adrenoceptors modulating release of acetylcholine in guinea-pig ileum

1995 • 25 citations

Heterologous expression of the cloned guinea pig α2A, α2B, and α2C adrenoceptor subtypes

1996 • 22 citations

Subtype classification of presynaptic α2-adrenoceptors

1993 • 21 citations

Summary of the ASPET-sponsored Colloquium: Alpha-2 adrenergic receptors: structure, function, and therapeutic implications, October 25-27, 1995.

1996 • 17 citations