Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

Molecular tinkering of G protein-coupled receptors: an evolutionary success

1999 • 1,479 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION

1998 • 1,074 citations

Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

1999 • 1,014 citations

μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

2000 • 869 citations

Regulation of Receptor Fate by Ubiquitination of Activated β ₂ -Adrenergic Receptor and β-Arrestin

2001 • 807 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

1995 • 714 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

1992 • 531 citations

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins

2002 • 519 citations

Desensitization of G-protein-coupled Receptors

1999 • 510 citations

Targeting of Cyclic AMP Degradation to β ₂ -Adrenergic Receptors by β-Arrestins

2002 • 496 citations

Mammalian RGS Proteins: Barbarians at the Gate

1998 • 487 citations

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

1987 • 478 citations

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

1993 • 467 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

beta -Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking

2001 • 346 citations

Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase

1999 • 343 citations

Essential role of β-adrenergic receptor kinase 1 in cardiac development and function

1996 • 336 citations

Prolonged photoresponses in transgenic mouse rods lacking arrestin

1997 • 334 citations

Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.

1992 • 330 citations

Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2

1999 • 315 citations

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

1985 • 312 citations

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

1992 • 306 citations

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

1994 • 300 citations

Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice

2002 • 298 citations

Ca2+-dependent Interaction of Recoverin with Rhodopsin Kinase

1995 • 278 citations

G protein-coupled receptor kinase 4 gene variants in human essential hypertension

2002 • 266 citations

Trafficking of the HIV Coreceptor CXCR4

1999 • 258 citations

Clathrin-mediated Endocytosis of the β-Adrenergic Receptor Is Regulated by Phosphorylation/Dephosphorylation of β-Arrestin1

1997 • 238 citations

PDE4 cAMP-specific phosphodiesterases

2001 • 234 citations

A Molecular Pathway for Light-Dependent Photoreceptor Apoptosis in Drosophila

2000 • 230 citations

The Formation of Stable Rhodopsin-Arrestin Complexes Induces Apoptosis and Photoreceptor Cell Degeneration

2000 • 229 citations

Arresting developments in heptahelical receptor signaling and regulation

2002 • 225 citations

β-Arrestins Regulate Protease-activated Receptor-1 Desensitization but Not Internalization or Down-regulation

2002 • 223 citations

Assembly of an A kinase-anchoring protein–β 2 -adrenergic receptor complex facilitates receptor phosphorylation and signaling

2000 • 219 citations

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

1991 • 214 citations

Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.

1996 • 205 citations

Inhibition of Rhodopsin Kinase by Recoverin

1995 • 204 citations

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.

1994 • 202 citations

β-Arrestin1 Knockout Mice Appear Normal but Demonstrate Altered Cardiac Responses to β-Adrenergic Stimulation

1997 • 200 citations

Characterization of the G Protein-coupled Receptor Kinase GRK4

1996 • 193 citations

Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice

1999 • 188 citations

Desensitization of the isolated .beta.2-adrenergic receptor by .beta.-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

1992 • 187 citations

Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES

1996 • 187 citations

Phosphorylation and Desensitization of Human Endothelin A and B Receptors

1997 • 185 citations

Feedback Inhibition of G Protein-coupled Receptor Kinase 2 (GRK2) Activity by Extracellular Signal-regulated Kinases

1999 • 183 citations

Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase.

1991 • 175 citations

Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the α1B-Adrenergic Receptor

1996 • 175 citations

Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.

1996 • 165 citations

Regulation of G Protein-coupled Receptor Kinases by Calmodulin and Localization of the Calmodulin Binding Domain

1997 • 165 citations

Control of Myocardial Contractile Function by the Level of β-Adrenergic Receptor Kinase 1 in Gene-targeted Mice

1998 • 163 citations

G Protein-coupled Receptor Kinase 3 (GRK3) Gene Disruption Leads to Loss of Odorant Receptor Desensitization

1997 • 162 citations

Phosphorylation and Activation of β-Adrenergic Receptor Kinase by Protein Kinase C

1995 • 160 citations

Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79

2001 • 158 citations

Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.

1994 • 141 citations

Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.

1993 • 139 citations

Vascular-Targeted Overexpression of G Protein-Coupled Receptor Kinase-2 in Transgenic Mice Attenuates β-Adrenergic Receptor Signaling and Increases Resting Blood Pressure

2002 • 137 citations

Feedback Regulation of β-Arrestin1 Function by Extracellular Signal-regulated Kinases

1999 • 136 citations

β-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2

2001 • 133 citations

Regulation of the G Protein-coupled Receptor Kinase GRK5 by Protein Kinase C

1997 • 131 citations

Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq.

2000 • 130 citations

Adjuvant Arthritis Induces Down-Regulation of G Protein-Coupled Receptor Kinases in the Immune System

2001 • 123 citations

β-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking

2001 • 121 citations

Mice Lacking G-Protein Receptor Kinase 1 Have Profoundly Slowed Recovery of Cone-Driven Retinal Responses

2000 • 119 citations

Selective Regulation of Gq Signaling by G Protein-Coupled Receptor Kinase 2: Direct Interaction of Kinase N Terminus with Activated Gαq

2000 • 115 citations

Degradation of the G Protein-coupled Receptor Kinase 2 by the Proteasome Pathway

1998 • 110 citations

Phosphorylation-independent Regulation of Metabotropic Glutamate Receptor Signaling by G Protein-coupled Receptor Kinase 2

2002 • 108 citations

Agonist-dependent Phosphorylation of the G Protein-coupled Receptor Kinase 2 (GRK2) by Src Tyrosine Kinase

1999 • 106 citations

c-Src Tyrosine Kinase Binds the β2-Adrenergic Receptor via Phospho-Tyr-350, Phosphorylates G-protein-linked Receptor Kinase 2, and Mediates Agonist-induced Receptor Desensitization

2001 • 105 citations

Inhibition of G Protein-coupled Receptor Kinase Subtypes by Ca2+/Calmodulin

1996 • 102 citations

Regulation of G‐protein‐coupled receptor kinase subtypes by calcium sensor proteins

1999 • 100 citations

Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.

1994 • 99 citations

A novel subtype of G-protein-coupled receptor kinase, GRK7, in teleost cone photoreceptors

1998 • 95 citations

Agonist-Dependent Modulation of G Protein-Coupled Receptor Kinase 2 by Mitogen-Activated Protein Kinases

2000 • 89 citations

Regulation of Rhodopsin Phosphorylation by a Family of Neuronal Calcium Sensors

1995 • 84 citations

Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein–Coupled Receptor Kinases in the Heart

2000 • 82 citations

The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas.

1998 • 81 citations

Regulation of G protein-coupled receptor kinase subtypes by calcium sensor proteins

2000 • 76 citations

Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs

1998 • 72 citations

Structure-Function Analysis of G Protein-coupled Receptor Kinase-5

1998 • 72 citations

Localization of the Sites for Ca²⁺-Binding Proteins on G Protein-Coupled Receptor Kinases

1998 • 70 citations

Characterization of G Protein-Coupled Receptor Regulation in Antisense mRNA-Expressing Cells with Reduced Arrestin Levels

1999 • 56 citations

Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3

1999 • 56 citations

A Role for Receptor Kinases in the Regulation of Class II G Protein-coupled Receptors

1998 • 50 citations

Vasoactive Intestinal Polypeptide Type-1 Receptor Regulation

2002 • 49 citations

Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs)11Abbreviations: PTH, parathyroid hormone; PTHrP, PTH-related protein; cAMP, cyclic AMP; Tris, tris(hydroxymethyl)-aminomethane; Kd, dissociation constant; Bmax, maximal number of specific binding sites; PLC, phospholipase C; G-protein, guanine nucleotide regulatory protein; DMEM, Dulbecco’s modified Eagle’s medium; RT-PCR, reverse transcription-polymerase chain reaction; IBMX, …

2001 • 43 citations