Nutritional modulation of ageing: Genomic and epigenetic approaches

Translating the Histone Code

2001 • 9,488 citations

Epigenetics in human disease and prospects for epigenetic therapy

2004 • 3,142 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Oxidative stress shortens telomeres

2002 • 2,362 citations

The history of cancer epigenetics

2004 • 2,270 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

The DNA methyltransferases of mammals

2000 • 1,981 citations

Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation

2003 • 1,970 citations

Understanding the Odd Science of Aging

2005 • 1,835 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

Gene-expression profile of the ageing brain in mice

2000 • 1,057 citations

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.

2003 • 1,035 citations

DNA Repair, Genome Stability, and Aging

2005 • 895 citations

Molecular Biology of Aging

1999 • 877 citations

Gardening the genome: DNA methylation in Arabidopsis thaliana

2005 • 861 citations

Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases

2003 • 788 citations

Nutrigenomics: goals and strategies

2003 • 643 citations

Accelerated age-related CpG island methylation in ulcerative colitis.

2001 • 624 citations

Moderate Folate Depletion Increases Plasma Homocysteine and Decreases Lymphocyte DNA Methylation in Postmenopausal Women

1998 • 493 citations

Zinc deficiency, DNA damage and cancer risk

2004 • 488 citations

Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice

2001 • 421 citations

DNA methylation and genetic instability in colorectal cancer cells

1997 • 400 citations

Age Related Changes in 5‐methylcytosine Content in Human Peripheral Leukocytes and Placentas: an HPLC‐based Study

2004 • 388 citations

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

2001 • 386 citations

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.

2002 • 383 citations

Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer.

2000 • 378 citations

Investigating stem cells in human colon by using methylation patterns

2001 • 356 citations

Retrotransposons as epigenetic mediators of phenotypic variation in mammals

2001 • 339 citations

All or nothing

2000 • 330 citations

Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts

2002 • 312 citations

Life extension in Drosophila by feeding a drug

2002 • 289 citations

Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

2002 • 285 citations

Temporal linkage between the phenotypic and genomic responses to caloric restriction

2004 • 261 citations

Dietary Selenium and Arsenic Affect DNA Methylation In Vitro in Caco-2 Cells and In Vivo in Rat Liver and Colon

2000 • 261 citations

Diallyl disulfide (DADS) increases histone acetylation and p21waf1/cip1 expression in human colon tumor cell lines

2004 • 249 citations

Nutritional modulation of DNA repair in a human intervention study

2003 • 242 citations

Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma

2005 • 241 citations

Aberrant CpG Island Hypermethylation of Chronic Gastritis, in Relation to Aging, Gender, Intestinal Metaplasia, and Chronic Inflammation

2003 • 237 citations

Nutrigenomics: exploiting systems biology in the nutrition and health arena

2002 • 212 citations

Aging, methylation and cancer.

2000 • 209 citations

Genistein Alters Methylation Patterns in Mice

2002 • 204 citations

Age-Associated Activation of Epigenetically Repressed Genes in the Mouse

2003 • 196 citations

Age-related epigenetic changes and the immune system

2003 • 183 citations

Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts.

2003 • 176 citations

Fidelity of the Methylation Pattern and Its Variation in the Genome

2003 • 166 citations

Anti-cancer effects of butyrate: use of micro-array technology to investigate mechanisms

2003 • 160 citations

Epigenetic Variation and Human Disease

2002 • 126 citations

Selenomethionine induction of DNA repair response in human fibroblasts

2002 • 117 citations

New careers for antioxidants

2002 • 111 citations

Roles for nutrients in epigenetic events

2005 • 105 citations

Association between low dietary folate intake and suboptimal cellular DNA repair capacity.

2003 • 81 citations

Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age‐related oxidative damage associated with environmental stress

2004 • 75 citations

Temporal and spatial patterns of transgene expression in aging adult mice provide insights about the origins, organization, and differentiation of the intestinal epithelium.

1991 • 47 citations

Gastrointestinal responses to oats consumption in young adult and elderly rats: digestion, large bowel fermentation and crypt cell proliferation rates

1993 • 45 citations

DNA Methylation in Aging and Cancer

1989 • 29 citations

Methylation of theESR1CpG island in the colorectal mucosa is an ‘all or nothing’ process in healthy human colon, and is accelerated by dietary folate supplementation in the mouse

2005 • 21 citations

Chairman's introduction: What can we expect to learn from genomics?

2004 • 17 citations

Diet, DNA methylation and cancer.

2003 • 10 citations

Nutrition and epigenetics – how the genome learns from experience

2005 • 5 citations