Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age‐related oxidative damage associated with environmental stress

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Protein Oxidation in Aging, Disease, and Oxidative Stress

1997 • 3,299 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

AP-1 function and regulation

1997 • 2,833 citations

The role of increasing temperature variability in European summer heatwaves

2004 • 2,714 citations

Invited Review: Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance

2002 • 1,387 citations

Heat-Related Deaths during the July 1995 Heat Wave in Chicago

1996 • 1,293 citations

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

2000 • 909 citations

Molecular Biology of Aging

1999 • 877 citations

[11] Redox potential of GSH/GSSG couple: Assay and biological significance

2002 • 773 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

2003 • 370 citations

Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury.

1998 • 334 citations

Lifespan Extension and Rescue of Spongiform Encephalopathy in Superoxide Dismutase 2 Nullizygous Mice Treated with Superoxide Dismutase–Catalase Mimetics

2001 • 285 citations

Salen−Manganese Complexes as Catalytic Scavengers of Hydrogen Peroxide and Cytoprotective Agents: Structure−Activity Relationship Studies

2002 • 267 citations

EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology

1999 • 266 citations

Lymphocyte proliferation modulated by glutamine: involved in the endogenous redox reaction

1999 • 242 citations

Salen-Manganese Complexes Are Superoxide Dismutase-Mimics

1993 • 207 citations

Liver damage in heatstroke

1970 • 186 citations

Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model

2001 • 183 citations

Mitochondria in organismal aging and degeneration

1999 • 178 citations

Salen- Manganese Complexes: Combined Superoxide Dismutase/Catalase Mimics with Broad Pharmacological Efficacy

1996 • 142 citations

Aging reduces adaptive capacity and stress protein expression in the liver after heat stress

2000 • 141 citations

A Simplified Method for the Preparation of Transcriptionally Active Liver Nuclear Extracts

1990 • 134 citations

Heat‐induced liver injury in old rats is associated with exaggerated oxidative stress and altered transcription factor activation

2003 • 113 citations

Caloric restriction improves thermotolerance and reduces hyperthermia‐induced cellular damage in old rats

2000 • 110 citations

Attenuation of Staurosporine-Induced Apoptosis, Oxidative Stress, and Mitochondrial Dysfunction by Synthetic Superoxide Dismutase and Catalase Mimetics, in Cultured Cortical Neurons

2001 • 95 citations

Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons

2000 • 91 citations

An analysis of the heat deaths in St. Louis during July, 1966.

1969 • 89 citations

Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria

1994 • 89 citations

Prevention and Suppression of Autoimmune Encephalomyelitis by EUK-8, a Synthetic Catalytic Scavenger of Oxygen-Reactive Metabolites

1997 • 89 citations

HSP70 accumulation in tissues of heat-stressed rats is blunted with advancing age

1995 • 78 citations

Oxidative Damage to DNA and Aging

2003 • 73 citations

Unifying Model of the Programmed (Intrinsic) and Stochastic (Extrinsic) Theories of Aging

1994 • 57 citations

Responses of rat mesenteric arteries to norepinephrine during exposure to heat stress and acidosis

1995 • 40 citations

Immunohistochemical localization of glutathione-S-transferase and glutathione peroxidase in adult Syrian hamster tissues and during kidney development.

1991 • 34 citations

Redox Regulation of Adenovirus-Induced AP-1 Activation by Overexpression of Manganese-Containing Superoxide Dismutase

2002 • 23 citations

Heat wave triggers political conflict as French death rates rise

2003 • 11 citations