Dietary Selenium and Arsenic Affect DNA Methylation In Vitro in Caco-2 Cells and In Vivo in Rat Liver and Colon

Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

1967 • 10,659 citations

Report of the American Institute of Nutrition Ad Hoc Committee on Standards for Nutritional Studies

1977 • 2,748 citations

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

1996 • 2,404 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin

1996 • 1,807 citations

Chemopreventive Agents

1998 • 672 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.

1984 • 529 citations

Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients.

1999 • 507 citations

Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong

1997 • 337 citations

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

1999 • 321 citations

Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis

1997 • 306 citations

Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.

1995 • 304 citations

Methyl groups in carcinogenesis: effects on DNA methylation and gene expression.

1992 • 301 citations

Serum Selenium and Subsequent Risk of Cancer Among Finnish Men and Women

1990 • 279 citations

Activity of methylated forms of selenium in cancer prevention.

1990 • 214 citations

Selenium in Forage Crops and Cancer Mortality in U.S. Counties

1991 • 206 citations

Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency

1993 • 204 citations

DNA methylation and chromatin structure

1991 • 182 citations

DNA methylation as an intermediate biomarker in colorectal cancer

1994 • 172 citations

A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China

1991 • 142 citations

A Metabolic Link between Arsenite and Selenite: The Seleno-bis(S-glutathionyl) Arsinium Ion

2000 • 141 citations

Chronic Alcohol Consumption Induces Genomic but Not p53-Specific DNA Hypomethylation in Rat Colon

1999 • 132 citations

Hyperhomocysteinemia induced by folic acid deficiency and methionine load — applications of a modified HPLC method

1996 • 121 citations

Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats

1995 • 110 citations

Selenium Metabolism

1962 • 103 citations

Selenium content of foods purchased in North Dakota

1996 • 91 citations

Effect of an inorganic and organic form of dietary selenium on the promotional stage of mammary carcinogenesis in the rat.

1984 • 85 citations

Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection

1989 • 82 citations

Role of DNA methylation in the regulation of cell function

1999 • 73 citations

Dietary Selenium Reduces the Formation of Aberrant Crypts in Rats Administered 3,2′-Dimethyl-4-aminobiphenyl

1999 • 64 citations

INFLUENCE OF DIETARY SELENIUM ON THE DISPOSITION OF ARSENATE IN THE FEMALE B6C3F₁, MOUSE

1997 • 58 citations

Isocratic high performance liquid chromatographic analysis of S‐adenosylmethionine and S‐adenosy ihomocysteine in animal tissues: the effect of exposure to nitrous oxide

1990 • 53 citations

Selenium metabolism

1966 • 52 citations

Periodate-oxidized adenosine inhibits the formation of dimethylselenide and trimethylselenonium ion in mice treated with selenite

1987 • 52 citations

Effects of DNA methylation on topoisomerase I and II cleavage activities.

1994 • 49 citations

Efficacy of trimethylselenonium versus selenite in cancer chemoprevention and its modulation by arsenite

1988 • 47 citations

Chemoprevention of mammary cancer by diallyl selenide, a novel organoselenium compound.

1996 • 46 citations

Effect of germanium on 1, 2-dimethylhydrazine-induced intestinal cancer in rats

1990 • 44 citations

Evaluation of organoselenium compounds for potential chemopreventive properties in colon carcinogenesis.

1994 • 43 citations

Synergistic toxicity between arsenic and methylated selenium compounds

1989 • 37 citations

INFLUENCE OF DIETARY SELENIUM ON THE DISPOSITION OF ARSENATE IN THE FEMALE B6C3F MOUSE 1

1997 • 34 citations

Selenium-arsenic interaction in renal cells: role of lysosomes. Electron microprobe study.

1994 • 33 citations

The stimulation and inhibition of the exhalation of volatile selenium

1986 • 31 citations

DNA methylation in eukaryotic chromosome stability

1991 • 29 citations

Inhibition of Chemical Carcinogenesis and Tumorigenesis by Selenium

1986 • 22 citations

The effect of dietary selenium deficiency on acute colorectal mucosal nucleotoxicity induced by several carcinogens in the rodent

1996 • 21 citations

Evidence for an Impairment in the Conversion of Methionine to Cysteine in the Selenium-Deficient Chick

1981 • 16 citations

Effect of Selenium on 1,2-dimethylhydrazine-induced intestinal cancer in rats

1996 • 15 citations

Biological role of DNA methylation: sequence-specific single-strand breaks associated with hypomethylation of GATC sites in Escherichia coli DNA

1986 • 11 citations

Structure-activity relationships among the ortho-, meta- and para-isomers of phenylenebis (methylene)seleno cyanate (XSC) as inhibitors of 7,12-dimethylbenz(a)anthracene-DNA binding in mammary glands of female CD rats

1997 • 7 citations