Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

Basic local alignment search tool

1990 • 87,358 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

1986 • 2,118 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

1991 • 1,489 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Molecular regulation of apoptosis: Genetic controls on cell death

1993 • 923 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

Sequence identification of 2,375 human brain genes

1992 • 764 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

A new class of yeast transcriptional activators

1987 • 706 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.

1993 • 602 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

New mammalian expression vectors

1990 • 525 citations

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

1988 • 499 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases.

1990 • 382 citations

Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells.

1982 • 356 citations

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1992 • 354 citations

Mechanism of cis-diamminedichloroplatinum(II)-induced cytotoxicity: role of G2 arrest and DNA double-strand breaks.

1988 • 307 citations

Mutants of GAL4 protein altered in an activation function

1987 • 281 citations

Bcl-2 associates with the ras-related protein R-rasp23

1993 • 259 citations

Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA

1984 • 195 citations

Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.

1994 • 159 citations

Mutations in the gene encoding the adenovirus early region 1B 19,000-molecular-weight tumor antigen cause the degradation of chromosomal DNA

1984 • 156 citations

The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells

1991 • 138 citations

Epstein-Barr Virus BHRF1 Protein Protects against Cell Death Induced by DNA-Damaging Agents and Heterologous Viral Infection

1994 • 136 citations

Adenovirus 2 lp+ locus codes for a 19 kd tumor antigen that plays an essential role in cell transformation

1983 • 128 citations

Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain.

1993 • 123 citations

The E1b oncogene of adenovirus confers cellular resistance to cytotoxicity of tumor necrosis factor and monoclonal anti-Fas antibody

1991 • 119 citations

Genetic studies with tumorigenic adenoviruses

1968 • 109 citations

19-kDa tumor antigen coded by early region E1b of adenovirus 2 is required for efficient synthesis and for protection of viral DNA.

1984 • 92 citations

cyt gene of adenoviruses 2 and 5 is an oncogene for transforming function in early region E1B and encodes the E1B 19,000-molecular-weight polypeptide

1984 • 82 citations

Nuclear envelope localization of an adenovirus tumor antigen maintains the integrity of cellular DNA.

1984 • 82 citations

SEQUENCES OF INTEREST: Rat Brain Calbindin D28: Six Domain Structure and Extensive Amino Acid Homology with Chicken Calbindin D28

1988 • 81 citations

Molecular cloning of cDNA encoding a “63”-kDa calmodulin-stimulated phosphodiesterase from bovine brain.

1992 • 72 citations

A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase.

1992 • 65 citations

Molecular cloning of DNA encoding a calmodulin-dependent phosphodiesterase enriched in striatum.

1992 • 63 citations

Degradation of intracellular DNA in KB cells infected with cyt mutants of human adenovirus type 12

1981 • 60 citations

Adenovirus cyt+ locus, which controls cell transformation and tumorigenicity, is an allele of lp+ locus, which codes for a 19-kilodalton tumor antigen

1984 • 52 citations

Mutational analysis of the transforming and apoptosis suppression activities of the adenovirus E1 B 175R protein

1993 • 34 citations

FUNCTIONAL SIMILARITY BETWEEN ADENOVIRUS E1B 19K GENE AND BCL2 ONCOGENE - MUTANT COMPLEMENTATION AND SUPPRESSION OF CELL-DEATH INDUCED BY DNA-DAMAGING AGENTS

1993 • 30 citations

An Adenovirus 2-Coded Tumor Antigen Located on the Endoplasmic Reticulum and Nuclear Envelope Is Required for Growth of Transformed Cells in Ca²⁺-Deficient Media

1985 • 7 citations

An Adenovirus Cytocidal Function Related to the Control of a Cellular pH 4 Endonuclease Activity

1985 • 7 citations

Deleted Work

1955 • 0 citations