Analyses of Single-Amino-Acid Substitution Mutants of Adenovirus Type 5 E1B-55K Protein

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1997 • 945 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

1988 • 606 citations

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1992 • 567 citations

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

1987 • 394 citations

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

1985 • 383 citations

Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells

1998 • 356 citations

The Adenovirus E1B-55K Transforming Polypeptide Modulates Transport or Cytoplasmic Stabilization of Viral and Host Cell mRNAs

1986 • 301 citations

p53 Status Does Not Determine Outcome of E1B 55-Kilodalton Mutant Adenovirus Lytic Infection

1998 • 295 citations

Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

1994 • 283 citations

p53-Independent and -Dependent Requirements for E1B-55K in Adenovirus Type 5 Replication

1999 • 260 citations

Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells

1997 • 244 citations

Inhibition of HeLa cell protein synthesis during adenovirus infection

1979 • 236 citations

Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport.

1985 • 234 citations

Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells

1984 • 221 citations

Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55k proteins

1990 • 207 citations

Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015)

2000 • 194 citations

A monoclonal antibody detecting the adenovirus type 5 E 1 b-58Kd tumor antigen: Characterization of the E 1 b-58Kd tumor antigen in adenovirus-infected and -transformed cells

1982 • 188 citations

Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence

1997 • 186 citations

The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells

1998 • 182 citations

In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy.

2000 • 178 citations

The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism.

1989 • 169 citations

Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: association with nuclear viral inclusions requires the early region 4 34-kilodalton protein

1991 • 154 citations

Effect of Adenovirus on Metabolism of Specific Host mRNAs: Transport Control and Specific Translational Discrimination

1983 • 151 citations

Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein.

1994 • 151 citations

Interaction of adenoviral E4 and E1b products in late gene expression

1990 • 143 citations

Inactivation of p53 but Not p73 by Adenovirus Type 5 E1B 55-Kilodalton and E4 34-Kilodalton Oncoproteins

1998 • 133 citations

Adenovirus E1B Proteins Are Required for Accumulation of Late Viral mRNA and for Effects on Cellular mRNA Translation and Transport

1985 • 117 citations

E1B 55-Kilodalton-Associated Protein: a Cellular Protein with RNA-Binding Activity Implicated in Nucleocytoplasmic Transport of Adenovirus and Cellular mRNAs

1998 • 110 citations

Preparation and Titration of CsCl-Banded Adenovirus Stocks

2007 • 106 citations

The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2

2000 • 106 citations

Isolation of type 5 adenovirus mutants with a cold-sensitive host range phenotype: Genetic evidence of an adenovirus transformation maintenance function

1982 • 103 citations

Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells

1996 • 101 citations

Structural analysis of the adenovirus type 5 E1B 55-kilodalton-E4orf6 protein complex

1997 • 99 citations

Dissection of functional domains in the adenovirus 2 early 1b 55k polypeptide by suppressor-linker insertional mutagenesis

1990 • 87 citations

E1B 55-Kilodalton Oncoproteins of Adenovirus Types 5 and 12 Inactivate and Relocalize p53, but Not p51 or p73, and Cooperate with E4orf6 Proteins To Destabilize p53

2000 • 76 citations

Targeting the Replication of Adenoviral Gene Therapy Vectors to Lung Cancer Cells: The Importance of the Adenoviral E1b-55kD Gene

1999 • 72 citations

Novel complementation cell lines derived from human lung carcinoma A549 cells support the growth of E1-deleted adenovirus vectors.

1996 • 59 citations

RNA-Binding Activity of the E1B 55-Kilodalton Protein from Human Adenovirus Type 5

1998 • 38 citations

Definition of a major p53 binding site on Ad2E1B58K protein and a possible nuclear localization signal on the Ad12E1B54K protein

1999 • 32 citations

Selective effects on adenovirus late gene expression of deleting the E1b 55K protein

1993 • 28 citations

Preparation and Titration of CsCl-Banded Adenovirus Stock

2003 • 13 citations

Cited By (0)

Loading...