Sphingosylphosphorylcholine Activation of Mitogen-activated Protein Kinase in Swiss 3T3 Cells Requires Protein Kinase C and a Pertussis Toxin-sensitive G Protein

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Oncogenes and signal transduction

1991 • 2,816 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

1984 • 567 citations

Phospholipid signaling

1995 • 561 citations

The MARCKS family of cellular protein kinase C substrates.

1993 • 484 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Acid and base hydrolysis of phosphoproteins bound to Immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins

1989 • 469 citations

Intracellular Calcium Release Mediated by Sphingosine Derivatives Generated in Cells

1990 • 391 citations

Lipid second messengers

1994 • 357 citations

Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets.

1983 • 294 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids

1993 • 281 citations

Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44erk-1 and p42erk-2

1995 • 274 citations

Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.

1992 • 240 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro.

1994 • 162 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Stimulation of Phospholipase D by Epidermal Growth Factor Requires Protein Kinase C Activation in Swiss 3T3 Cells

1995 • 143 citations

Neuropeptides as cellular growth factors: role of multiple signalling pathways

1991 • 131 citations

Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.

1994 • 130 citations

Bombesin, diacylglycerols, and phorbol esters rapidly stimulate the phosphorylation of an Mr = 80,000 protein kinase C substrate in permeabilized 3T3 cells. Effect of guanine nucleotides.

1988 • 120 citations

Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts.

1993 • 117 citations

Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines

1991 • 109 citations

Sphingosylphosphorylcholine Rapidly Induces Tyrosine Phosphorylation of p125 and Paxillin, Rearrangement of the Actin Cytoskeleton and Focal Contact Assembly

1995 • 103 citations

Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate.

1994 • 90 citations

Identification of multiple PKC isoforms in Swiss 3T3 cells: Differential down‐regulation by phorbol ester

1992 • 90 citations

Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.

1994 • 88 citations

Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells

1993 • 81 citations

Molecular cloning and characterization of the acidic 80-kDa protein kinase C substrate from rat brain. Identification as a glycoprotein.

1991 • 78 citations

Lipid Storage Disorders

1988 • 69 citations

Studies in vitro on the Biosynthesis of Ceramide and Sphingomyelin A Reevaluation of Proposed Pathways

1980 • 67 citations

Characterization of a novel intracellular sphingolipid-gated Ca(2+)-permeable channel from rat basophilic leukemia cells.

1994 • 66 citations

The human CCKB/gastrin receptor transfected into rat1 fibroblasts mediates activation of MAP kinase, p74raf-1 kinase, and mitogenesis.

1995 • 66 citations

Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells

1993 • 57 citations

How does the G protein, G_i2, transduce mitogenic signals?

1994 • 56 citations

Investigation of the enzymatic synthesis of sphingomyelin

1968 • 48 citations

Meningioma phospholipid profiles measured by³¹P nuclear magnetic resonance spectroscopy

1994 • 34 citations

Thapsigargin and di-tert-butylhydroquinone induce synergistic stimulation of DNA synthesis with phorbol ester and bombesin in Swiss 3T3 cells.

1994 • 30 citations

A novel approach to detect toxin-catalyzed ADP-ribosylation in intact cells: its use to study the action of Pasteurella multocida toxin.

1991 • 25 citations

Enzymic synthesis of sphingosylphosphorylcholine

1968 • 24 citations