Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

Staphylococcal Protease: A Proteolytic Enzyme Specific for Glutamoyl Bonds

1972 • 703 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

PKCu is a novel, atypical member of the protein kinase C family.

1994 • 519 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

The Marcks brothers: A family of protein kinase C substrates

1992 • 474 citations

Tissue-specific expression of three distinct types of rabbit protein kinase C

1987 • 469 citations

A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.

1990 • 434 citations

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family

1988 • 414 citations

Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.

1992 • 394 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Protein kinase C phosphorylates human platelet inositol trisphosphate 5′-phosphomonoesterase, increasing the phosphatase activity

1986 • 354 citations

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

1993 • 352 citations

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.

1992 • 340 citations

Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C.

1989 • 318 citations

Expression and Properties of Two Types of Protein Kinase C: Alternative Splicing from a Single Gene

1987 • 317 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

The influence of basic residues on the substrate specificity of protein kinase C.

1987 • 287 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C

1989 • 241 citations

Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid.

1988 • 239 citations

A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.

1994 • 236 citations

Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.

1991 • 233 citations

Expression, purification, and characterization of protein kinase C-epsilon.

1990 • 231 citations

Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.

1986 • 231 citations

Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II.

1988 • 218 citations

Stimulus-dependent myristoylation of a major substrate for protein kinase C

1988 • 216 citations

Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.

1991 • 212 citations

Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia.

1990 • 195 citations

Characterization of the phosphorylation sites in the chicken and bovine myristoylated alanine-rich C kinase substrate protein, a prominent cellular substrate for protein kinase C

1989 • 136 citations

Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC

1991 • 134 citations

Phosphorylation of cardiac troponin by guanosine 3‘:5‘-monophosphate-dependent protein kinase.

1978 • 134 citations

Iron-responsive element-binding protein. Phosphorylation by protein kinase C.

1993 • 128 citations

Phosphorylation of glycogen synthase by the Ca2+- and phospholipid-activated protein kinase (protein kinase C).

1984 • 127 citations

Phosphorylation-dependent binding of a synthetic MARCKS peptide to calmodulin.

1991 • 126 citations

Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites

1989 • 126 citations

Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain.

1987 • 122 citations

Interaction cloning of protein kinase C substrates.

1993 • 122 citations

MacMARCKS, a novel member of the MARCKS family of protein kinase C substrates

1992 • 120 citations

Purification and characterization of an Mr 87,000 protein kinase C substrate from rat brain.

1987 • 117 citations

Structure and properties of a ubiquitously expressed protein kinase C, nPKCδ

1991 • 105 citations

Protein kinase C substrate and inhibitor characteristics of peptides derived from the myristoylated alanine-rich C kinase substrate (MARCKS) protein phosphorylation site domain

1991 • 105 citations

Protein kinase C and phosphatidylserine bind to Mr 110,000/115,000 polypeptides enriched in cytoskeletal and postsynaptic density preparations.

1986 • 95 citations

Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein.

1994 • 91 citations

Neuron-specific protein F1GAP-43 shows substrate specificity for the beta subtype of protein kinase C

1990 • 89 citations

Cloning and molecular characterization of the murine macrophage "68-kDa" protein kinase C substrate and its regulation by bacterial lipopolysaccharide.

1991 • 85 citations

The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization

1991 • 85 citations

Purified protein kinase C phosphorylates microtubule-associated protein 2.

1986 • 82 citations

A fourth type of rabbit protein kinase C

1988 • 80 citations

Molecular cloning and characterization of the acidic 80-kDa protein kinase C substrate from rat brain. Identification as a glycoprotein.

1991 • 78 citations

Protein kinase C phosphorylates tau and induces its functional alterations

1987 • 78 citations

Purification and characterization of protein kinase C .epsilon. from rabbit brain

1992 • 77 citations

Phosphorylation of the EGF receptor from A431 epidermoid carcinoma cells by three distinct types of protein kinase C

1987 • 75 citations

Characteristics of the F52 protein, a MARCKS homologue.

1992 • 72 citations

SEQUENCES OF INTEREST: Molecular Cloning, Sequence, and Expression of a cDNA Encoding the Chicken Myristoylated Alanine-Rich C Kinase Substrate (MARCKS)

1989 • 65 citations

Cell type-specific expression of the genes for the protein kinase C family: Down regulation of mRNAs for PKCα and nPKCε upon in vitro differentiation of a mouse neuroblastoma cell line Neuro 2a

1989 • 62 citations

Protein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cells.

1991 • 62 citations

Differential stimulation of protein kinase C activity by phorbol ester or calcium/phosphatidylserine in vitro and in intact synaptosomes.

1992 • 60 citations

A mouse brain cDNA encodes a novel protein with the protein kinase C phosphorylation site domain common to MARCKS

1991 • 49 citations

Studies on the primary sequence requirements for PKC‐α, ‐β₁ and ‐γ peptide substrates

1990 • 49 citations

Phosphorylation of HIV-1 gag proteins by protein kinase C.

1993 • 38 citations

Identity of the particulate form of calmodulin with soluble calmodulin

1981 • 34 citations

In vitro phosphorylation of human complement factor C3 by protein kinase A and protein kinase C. Effects on the classical and alternative pathways.

1990 • 34 citations

Correlation between protein kinase C binding proteins and substrates in REF52 cells.

1994 • 34 citations

Multisite phosphorylation of the 80 kDa (MARCKS) protein kinase C substrate in C3H/10T1/2 fibroblasts Quantitative analysis of individual sites by solid‐phase microsequencing

1992 • 24 citations

Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: Major substrate for protein kinase C

1992 • 13 citations