Thapsigargin and di-tert-butylhydroquinone induce synergistic stimulation of DNA synthesis with phorbol ester and bombesin in Swiss 3T3 cells.

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

1989 • 583 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrations

1991 • 452 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1992 • 430 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger

1993 • 363 citations

Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism

1980 • 334 citations

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

1991 • 321 citations

The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum

1990 • 310 citations

Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes.

1992 • 277 citations

Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton

1993 • 277 citations

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase.

1984 • 266 citations

Intracellular Ca2+ pool content is linked to control of cell growth.

1993 • 260 citations

Identification of intracellular calcium pools. Selective modification by thapsigargin

1991 • 238 citations

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells.

1993 • 209 citations

Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors

1978 • 207 citations

Persistent intracellular calcium pool depletion by thapsigargin and its influence on cell growth.

1991 • 206 citations

2,5‐Di(tert‐butyl)‐1,4‐benzohydroquinone — a novel inhibitor of liver microsomal Ca²⁺ sequestration

1987 • 204 citations

Calcium-Dependent Regulation of Protein Synthesis in Intact Mammalian Cells

1990 • 198 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pH.

1986 • 164 citations

Noradrenaline, vasopressin and angiotensin increase Ca2+ influx by opening a common pool of Ca2+ channels in isolated rat liver cells

1984 • 164 citations

Cytochrome P-450 may link intracellular Ca2+ stores with plasma membrane Ca2+ influx

1991 • 164 citations

Cyclic AMP: a mitogenic signal for Swiss 3T3 cells.

1981 • 150 citations

Pasteurella multocida toxin: potent mitogen for cultured fibroblasts.

1990 • 131 citations

Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells.

1987 • 126 citations

Temporal relationship between inositol polyphosphate formation and increases in cytosolic Ca2+ in quiescent 3T3 cells stimulated by platelet-derived growth factor, bombesin and vasopressin.

1988 • 125 citations

Stimulation of Na+H+ antiport activity by epidermal growth factor and insulin occurs without activation of protein kinase C

1985 • 112 citations

Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2.

1993 • 106 citations

Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol.

1992 • 105 citations

Identification of multiple PKC isoforms in Swiss 3T3 cells: Differential down‐regulation by phorbol ester

1992 • 90 citations

Growth factors and cell proliferation

1992 • 77 citations

Early Signals Underlying the induction of the c-fos and c-myc Genes in Quiescent Fibroblasts: Studies with Bombesin and Other Growth Factors

1988 • 72 citations

Bradykinin transiently activates protein kinase C in Swiss 3T3 cells. Distinction from activation by bombesin and vasopressin.

1990 • 70 citations

Chronic desensitization to bombesin by progressive down-regulation of bombesin receptors in Swiss 3T3 cells. Distinction from acute desensitization.

1990 • 69 citations

Pasteurella multocida toxin selectively facilitates phosphatidylinositol 4,5-bisphosphate hydrolysis by bombesin, vasopressin, and endothelin. Requirement for a functional G protein.

1992 • 65 citations

Protein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cells.

1991 • 62 citations

Pasteurella multocida toxin is a potent inducer of anchorage-independent cell growth.

1992 • 53 citations

Control of plasma-membrane Ca2+ entry by the intracellular Ca2+ stores. Kinetic evidence for a short-lived mediator

1992 • 48 citations

Calcium ion activation of rabbit liver alpha 1,2-mannosidase.

1990 • 46 citations

Vasopressin rapidly stimulates Ca2+ efflux from intracellular pool in quiescent Swiss 3T3 cells

1984 • 30 citations

CD3 Monoclonal Antibodies Evoke the Same Cytochrome P450-Regulated Capacitative Entry of Calcium as Thapsigargin in Jurkat T Cells

1993 • 3 citations