The MARCKS family of cellular protein kinase C substrates.

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

1988 • 3,446 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

Axonal Growth-Associated Proteins

1989 • 1,118 citations

How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices

1990 • 839 citations

THE BIOLOGY AND ENZYMOLOGY OF EUKARYOTIC PROTEIN ACYLATION

1988 • 787 citations

Calmodulin

1982 • 771 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.

1984 • 447 citations

Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

1985 • 351 citations

Regulation of calmodulin binding to P-57. A neurospecific calmodulin binding protein.

1987 • 334 citations

Phosphoinositides and receptor mechanisms

1987 • 320 citations

Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C.

1989 • 318 citations

A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor

1990 • 278 citations

Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain.

1986 • 277 citations

Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C

1989 • 241 citations

Regulation of free calmodulin levels by neuromodulin: neuron growth and regeneration

1990 • 226 citations

Stimulus-dependent myristoylation of a major substrate for protein kinase C

1988 • 216 citations

An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins

1985 • 201 citations

Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia.

1990 • 195 citations

Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail.

1991 • 188 citations

Widespread occurrence of "87 kDa," a major specific substrate for protein kinase C.

1986 • 176 citations

The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activity

1986 • 174 citations

Identification of a 32K plasma membrane protein that binds to the myristylated amino-terminal sequence of p60v-src

1990 • 162 citations

Purified rat brain calcium- and phospholipid-dependent protein kinase phosphorylates ribosomal protein S6.

1983 • 160 citations

The 87-kDa protein, a major specific substrate for protein kinase C: purification from bovine brain and characterization.

1987 • 138 citations

Specific and saturable binding of pp60v-src to plasma membranes: Evidence for a myristyl-src receptor

1989 • 137 citations

Characterization of the phosphorylation sites in the chicken and bovine myristoylated alanine-rich C kinase substrate protein, a prominent cellular substrate for protein kinase C

1989 • 136 citations

Cross-talk between protein kinase C and multifunctional Ca2+/calmodulin-dependent protein kinase.

1992 • 134 citations

Phosphorylation-dependent binding of a synthetic MARCKS peptide to calmodulin.

1991 • 126 citations

MacMARCKS, a novel member of the MARCKS family of protein kinase C substrates

1992 • 120 citations

Purification and characterization of an Mr 87,000 protein kinase C substrate from rat brain.

1987 • 117 citations

Protein kinase C substrate and inhibitor characteristics of peptides derived from the myristoylated alanine-rich C kinase substrate (MARCKS) protein phosphorylation site domain

1991 • 105 citations

Protein kinase C-dependent and -independent pathways of proto-oncogene induction in human astrocytoma cells.

1987 • 99 citations

Tumor necrosis factor alpha modifies agonist-dependent responses in human neutrophils by inducing the synthesis and myristoylation of a specific protein kinase C substrate.

1990 • 95 citations

Myristoylated and Nonmyristoylated Forms of a Protein Are Phosphorylated by Protein Kinase C

1989 • 89 citations

A Collection of cDNA Clones with Specific Expression Patterns in Mouse Brain

1990 • 86 citations

Cloning and molecular characterization of the murine macrophage "68-kDa" protein kinase C substrate and its regulation by bacterial lipopolysaccharide.

1991 • 85 citations

The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization

1991 • 85 citations

Molecular cloning and characterization of the acidic 80-kDa protein kinase C substrate from rat brain. Identification as a glycoprotein.

1991 • 78 citations

Characteristics of the F52 protein, a MARCKS homologue.

1992 • 72 citations

Insulin activation of protein kinase C: a reassessment

1991 • 65 citations

SEQUENCES OF INTEREST: Molecular Cloning, Sequence, and Expression of a cDNA Encoding the Chicken Myristoylated Alanine-Rich C Kinase Substrate (MARCKS)

1989 • 65 citations

Phorbol ester-induced down-regulation of the 80-kDa myristoylated alanine-rich C-kinase substrate-related protein in Swiss 3T3 fibroblasts. Inhibition by staurosporine.

1992 • 64 citations

Protein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cells.

1991 • 62 citations

Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor.

1992 • 60 citations

Affinity purification and characterization of myristoylated alanine-rich protein kinase C substrate (MARCKS) from bovine brain. Comparison of the cytoplasmic and the membrane-bound forms.

1992 • 60 citations

Muscarinic receptor-mediated translocation of calmodulin in SK-N-SH human neuroblastoma cells.

1990 • 57 citations

Myristoylation, Phosphorylation, and Subcellular Distribution of the 80-kDa Protein Kinase C Substrate in BC3H1 Myocytes

1989 • 55 citations

Cell membranes; Methods and reviews

1985 • 54 citations

A mouse brain cDNA encodes a novel protein with the protein kinase C phosphorylation site domain common to MARCKS

1991 • 49 citations

The expression of 80K/MARCKS, a major substrate of protein kinase C (PKC), is down-regulated through both PKC-dependent and -independent pathways. Effects of bombesin, platelet-derived growth factor, and cAMP.

1992 • 47 citations

Evidence for a non-myristoylated pool of the 80 kDa protein kinase C substrate of rat brain

1990 • 35 citations

Differential expression of an 80-kDa protein kinase C substrate in preneoplastic and neoplastic mouse JB6 cells.

1989 • 28 citations

Multisite phosphorylation of the 80 kDa (MARCKS) protein kinase C substrate in C3H/10T1/2 fibroblasts Quantitative analysis of individual sites by solid‐phase microsequencing

1992 • 24 citations

Chromosomal mapping of the human (MACS) and mouse (Macs) genes encoding the MARCKS protein

1992 • 22 citations

A Major Myristylated Substrate of Protein Kinase C and Protein Kinase C Itself Are Differentially Regulated during Murine B-and T-Lymphocyte Development and Activation

1989 • 20 citations

Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: Major substrate for protein kinase C

1992 • 13 citations

Cell cycle and growth factor‐dependent phosphoprotein of 78kD differently regulated in normal and transformed mouse fibroblasts

1987 • 13 citations

Altered levels and protein kinase C-mediated phosphorylation of substrates in normal and transformed mouse lung epithelial cells

1992 • 6 citations