Stimulation of Phospholipase D by Epidermal Growth Factor Requires Protein Kinase C Activation in Swiss 3T3 Cells

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Epidermal growth factor.

1990 • 1,645 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Chelerythrine is a potent and specific inhibitor of protein kinase C

1990 • 1,208 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Potent selective inhibitors of protein kinase C

1989 • 482 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.

1985 • 332 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells.

1987 • 230 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

Cell growth and differentiation

2005 • 226 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate.

1985 • 218 citations

Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.

1988 • 207 citations

Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism

1989 • 188 citations

Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol

1993 • 182 citations

Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.

1984 • 180 citations

Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate.

1987 • 168 citations

Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

1988 • 161 citations

Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts.

1986 • 156 citations

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.

1992 • 156 citations

Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor

1979 • 154 citations

Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells.

1990 • 134 citations

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

1991 • 134 citations

Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2.

1994 • 133 citations

Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C.

1988 • 131 citations

Expression of the alpha, beta II, and gamma protein kinase C isozymes in the baculovirus-insect cell expression system. Purification and characterization of the individual isoforms.

1990 • 120 citations

Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway.

1990 • 113 citations

Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells.

1992 • 103 citations

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D

1991 • 97 citations

EGF and insulin action in fibroblasts

1986 • 93 citations

Bombesin, platelet-derived growth factor, and diacylglycerol induce selective membrane association and down-regulation of protein kinase C isotypes in Swiss 3T3 cells.

1994 • 93 citations

Identification of multiple PKC isoforms in Swiss 3T3 cells: Differential down‐regulation by phorbol ester

1992 • 90 citations

Phospholipase D activation in fibroblast membranes by the α and β isoforms of protein kinase C

1994 • 90 citations

Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis

1992 • 88 citations

Up-regulation of phospholipase D activity induced by overexpression of protein kinase C-alpha. Studies in intact Swiss/3T3 cells and in detergent-solubilized membranes in vitro

1993 • 84 citations

Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor.

1994 • 80 citations

Sustained increase in 1,2-diacylglycerol precedes DNA synthesis in epidermal-growth-factor-stimulated fibroblasts. Evidence for stimulated phosphatidylcholine hydrolysis

1990 • 73 citations

Differential regulation of phosphoinositide and phosphatidylcholine hydrolysis by protein kinase C-beta 1 overexpression. Effects on stimulation by alpha-thrombin, guanosine 5'-O-(thiotriphosphate), and calcium.

1992 • 72 citations

Mass measurement of inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol in bombesin-stimulated Swiss 3T3 mouse fibroblasts

1990 • 67 citations

Activation and desensitization of phospholipase D in intact rat hepatocytes.

1994 • 60 citations

v-Src activates a unique phospholipase D activity that can be distinguished from the phospholipase D activity activated by phorbol esters

1993 • 60 citations

Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells

1989 • 56 citations

Regulation of phospholipase D-induced hydrolysis of choline-containing phosphoglycerides by cyclic AMP in human neutrophils.

1991 • 55 citations

Hydrolysis of phosphatidylcholine by phospholipase D is a common response to mitogens which stimulate inositol lipid hydrolysis in Swiss 3T3 fibroblasts

1991 • 51 citations

A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils.

1992 • 49 citations

Basic FGF activates phospholipase D in endothelial cells in the absence of inositol-lipid hydrolysis

1994 • 47 citations

Distinct mechanisms of phospholipase D activation and attenuation utilized by different mitogens in NIH‐3T3 fibroblasts

1993 • 42 citations

Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C beta 1.

1991 • 41 citations

Epidermal growth factor induces the production of biologically distinguishable diglyceride species from phosphatidylinositol and phosphatidylcholine via the independent activation of type C and type D phospholipases.

1994 • 38 citations

Phospholipase D activation in human natural killer cells through the Kp43 and CD16 surface antigens takes place by different mechanisms. Involvement of the phospholipase D pathway in tumor necrosis factor alpha synthesis.

1992 • 36 citations

A role for protein kinase C‐ϵ in angiotensin II stimulation of phospholipase D in rat renal mesangial cells

1993 • 35 citations

Human neutrophils incorporate arachidonic acid and saturated fatty acids into separate molecular species of phospholipids

1987 • 32 citations

Rapid desensitization and resensitization of bombesin-stimulated phospholipase D activity in Swiss 3T3 cells

1994 • 24 citations

Preferential incorporation of eicosanoid precursor fatty acids into human umbilical vein endothelial cell phospholipids

1987 • 22 citations

Phospholipase-D activation can be negatively regulated through the action of protein kinase C

1994 • 9 citations