NADPH Oxidase Restrains the Matrix Metalloproteinase Activity of Macrophages

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

Protein Oxidation in Aging, Disease, and Oxidative Stress

1997 • 3,299 citations

Matrix metalloproteinases as modulators of inflammation and innate immunity

2004 • 1,833 citations

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2002 • 1,781 citations

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

1997 • 1,463 citations

Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis

2002 • 1,460 citations

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1996 • 1,382 citations

Matrix metalloproteinases: they're not just for matrix anymore!

2001 • 1,257 citations

Metalloproteinase inhibitors: biological actions and therapeutic opportunities

2002 • 1,159 citations

Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.

1996 • 1,132 citations

Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials

2003 • 1,094 citations

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

1995 • 920 citations

The Neutrophil NADPH Oxidase

2002 • 904 citations

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

2000 • 771 citations

Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury

2002 • 734 citations

The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis

2001 • 699 citations

A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2

2003 • 643 citations

Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon.

1991 • 600 citations

Quantitative Methods in the Study of Pulmonary Pathology

1962 • 597 citations

Simultaneous Detection of 15 Human Cytokines in a Single Sample of Stimulated Peripheral Blood Mononuclear Cells

2003 • 579 citations

TIMPs as multifacial proteins

2004 • 525 citations

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.

1996 • 496 citations

TIMP-2 Mediated Inhibition of Angiogenesis

2003 • 494 citations

Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema

2003 • 480 citations

Hypochlorous Acid Oxygenates the Cysteine Switch Domain of Pro-matrilysin (MMP-7)

2001 • 473 citations

Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis

1998 • 471 citations

Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice

2000 • 407 citations

Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein

2003 • 385 citations

TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo

2000 • 383 citations

Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein

2003 • 382 citations

Matrix metalloproteinases in lung biology

2000 • 377 citations

Absence of Respiratory Burst in X-linked Chronic Granulomatous Disease Mice Leads to Abnormalities in Both Host Defense and Inflammatory Response to Aspergillus fumigatus

1997 • 370 citations

Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein.

1994 • 334 citations

Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency

2002 • 261 citations

Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease.

1998 • 247 citations

Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines

2004 • 213 citations

Respiratory-related neuronal activity in the nucleus ambiguus-retroambigualis complex and their responses to peripheral and central stimulation in the rat

2001 • 160 citations

Hypochlorous Acid Generated by Myeloperoxidase Modifies Adjacent Tryptophan and Glycine Residues in the Catalytic Domain of Matrix Metalloproteinase-7 (Matrilysin)

2003 • 148 citations

Defect in Pyridine Nucleotide Dependent Superoxide Production by a Particulate Fraction from the Granulocytes of Patients with Chronic Granulomatous Disease

1975 • 148 citations

Inactivating Mutation of the Mouse Tissue Inhibitor of Metalloproteinases-2(Timp-2) Gene Alters ProMMP-2 Activation

2000 • 147 citations

Quantum proteolysis by neutrophils: implications for pulmonary emphysema in α1-antitrypsin deficiency

1999 • 136 citations

Phagocytes Produce 5-Chlorouracil and 5-Bromouracil, Two Mutagenic Products of Myeloperoxidase, in Human Inflammatory Tissue

2003 • 135 citations

Oxidized amino acids: culprits in human atherosclerosis and indicators of oxidative stress 1,2 1This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Earl Stadtman

2002 • 111 citations

Deficiency of NADPH Oxidase Components p47phox and gp91phox Caused Granulomatous Synovitis and Increased Connective Tissue Destruction in Experimental Arthritis Models

2003 • 93 citations

Oxidative Cross-linking of Tryptophan to Glycine Restrains Matrix Metalloproteinase Activity

2004 • 92 citations

Matrilysin-dependent Elastolysis by Human Macrophages

2003 • 65 citations

Different effects of hypochlorous acid on human neutrophil metalloproteinases: Activation of collagenase and inactivation of collagenase and gelatinase

1992 • 65 citations

Analysis of lapine cartilage matrix after radiosynovectomy with holmium-166 ferric hydroxide macroaggregate

2002 • 34 citations