Matrix metalloproteinases in lung biology

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

2016 • 7,054 citations

Matrix Metalloproteinases

1999 • 3,774 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

1998 • 1,753 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

1997 • 1,463 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

1999 • 1,280 citations

Matrix metalloproteinases: effectors of development and normal physiology

2000 • 1,236 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

1998 • 887 citations

Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms

2000 • 808 citations

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

2000 • 797 citations

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

1999 • 790 citations

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

2000 • 771 citations

Matrix metalloproteinase degradation of extracellular matrix: biological consequences

1998 • 726 citations

Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells

1997 • 633 citations

Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase– and cathepsin-dependent emphysema

2000 • 624 citations

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

1997 • 612 citations

Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon.

1991 • 600 citations

The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix

1997 • 600 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

Chemotactic activity of elastin-derived peptides.

1980 • 519 citations

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.

1996 • 496 citations

Matrix Metalloproteinase Expression and Production by Alveolar Macrophages in Emphysema

1997 • 444 citations

TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo

2000 • 383 citations

Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema

1992 • 378 citations

The Serpin α1-Proteinase Inhibitor Is a Critical Substrate for Gelatinase B/MMP-9 In Vivo

2000 • 371 citations

Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.

1996 • 359 citations

Matrix metalloproteinase-7–dependent release of tumor necrosis factor-α in a model of herniated disc resorption

2000 • 357 citations

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

1996 • 353 citations

Unaltered Secretion of β-Amyloid Precursor Protein in Gelatinase A (Matrix Metalloproteinase 2)-deficient Mice

1997 • 352 citations

Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema.

1998 • 334 citations

Matrix Metalloproteinase-3 Releases Active Heparin-binding EGF-like Growth Factor by Cleavage at a Specific Juxtamembrane Site

1997 • 329 citations

Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.

1993 • 319 citations

In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

1998 • 290 citations

Matrilysin expression and function in airway epithelium.

1998 • 277 citations

Identification and Characterization of the Fifth Membrane-type Matrix Metalloproteinase MT5-MMP

1999 • 261 citations

Gelatinase B–deficient Mice Are Resistant to Experimental Bullous Pemphigoid

1998 • 236 citations

Heparan Sulfate Proteoglycans as Extracellular Docking Molecules for Matrilysin (Matrix Metalloproteinase 7)

2000 • 234 citations

Airway Epithelial Cell Migration Dynamics: MMP-9 Role in Cell–Extracellular Matrix Remodeling

1999 • 233 citations

Impaired Wound Contraction in Stromelysin-1–Deficient Mice

1999 • 232 citations

Cloning and Characterization of Human MMP-23, a New Matrix Metalloproteinase Predominantly Expressed in Reproductive Tissues and Lacking Conserved Domains in Other Family Members

1999 • 226 citations

The Matrix Metalloproteinase Family

1998 • 225 citations

Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.

1994 • 217 citations

Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity.

2000 • 206 citations

Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction

1998 • 203 citations

Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage

1999 • 203 citations

Identification and Characterization of Human Endometase (Matrix Metalloproteinase-26) from Endometrial Tumor

2000 • 197 citations

Elastolytic Metalloproteinases Produced by Human Mononuclear Phagocytes: Potential Roles in Destructive Lung Disease

1994 • 190 citations

Gelatinase B Is Required for Alveolar Bronchiolization after Intratracheal Bleomycin

2000 • 185 citations

Spatial distribution of collagen and elastin fibers in the lungs

1990 • 181 citations

Bacterial Exposure Induces and Activates Matrilysin in Mucosal Epithelial Cells

2000 • 174 citations

Membrane Type 4 Matrix Metalloproteinase (MT4-MMP, MMP-17) Is a Glycosylphosphatidylinositol-anchored Proteinase

1999 • 163 citations

The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse.

1995 • 150 citations

Inactivating Mutation of the Mouse Tissue Inhibitor of Metalloproteinases-2(Timp-2) Gene Alters ProMMP-2 Activation

2000 • 147 citations

Membrane‐type 6 matrix metalloproteinase (MT6‐MMP, MMP‐25) is the second glycosyl‐phosphatidyl inositol (GPI)‐anchored MMP

2000 • 135 citations

Matrix metalloproteinase deficiencies affect contact hypersensitivity: Stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response

1999 • 131 citations

Marimastat (BB2516): Current status of development

1999 • 131 citations

Neutrophil Emigration in the Lungs, Peritoneum, and Skin Does Not Require Gelatinase B

1999 • 131 citations

Matrilysin Is Much More Efficient Than Other Matrix Metalloproteinases in the Proteolytic Inactivation of α1-Antitrypsin

1994 • 128 citations

Identification of MMP-18, a Putative Novel Human Matrix Metalloproteinase

1996 • 123 citations

Studies on the ability of 65-kDa and 92-kDa tumor cell gelatinases to degrade type IV collagen.

1990 • 118 citations

Cloning of MMP‐26

2000 • 111 citations

A pilot study of the safety and effects of the matrix metalloproteinase inhibitor marimastat in gastric cancer

1999 • 84 citations

Matrilysin (PUMP) Correlates with Dermal Invasion During Appendageal Development and Cutaneous Neoplasia

1994 • 78 citations

Membrane Type-1 Matrix Metalloprotease and Stromelysin-3 Cleave More Efficiently Synthetic Substrates Containing Unusual Amino Acids in Their P1′ Positions

1998 • 60 citations

Accelerated Neointima Formation After Vascular Injury in Mice With Stromelysin-3 (MMP-11) Gene Inactivation

1999 • 54 citations

CA‐MMP: a matrix metalloproteinase with a novel cysteine array, but without the classic cysteine switch

1999 • 53 citations

Matrilysin

1998 • 20 citations