Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease.

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1996 • 2,502 citations

Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation

1997 • 2,216 citations

The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

1995 • 1,512 citations

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

1998 • 1,494 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria

1994 • 1,199 citations

FcR γ chain deletion results in pleiotrophic effector cell defects

1994 • 967 citations

Single base polymorphism in the human Tumour Necrosis Factor alpha (TNFα) gene detectable by Ncol restriction of PCR product

1992 • 903 citations

The −308 tumor necrosis factor-α promoter polymorphism effects transcription

1997 • 868 citations

FcγRIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell FcγRIIIa, Independently of the FcγRIIIa-48L/R/H Phenotype

1997 • 760 citations

Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant

1998 • 725 citations

Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications

1993 • 706 citations

A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.

1997 • 698 citations

Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat

1993 • 688 citations

Molecular basis of opsonic defect in immunodeficient children

1991 • 559 citations

Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism

1995 • 543 citations

A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein

1994 • 507 citations

A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding.

1991 • 460 citations

Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis.

1995 • 459 citations

Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease

1996 • 424 citations

Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk

1997 • 423 citations

An Alu Element in the Myeloperoxidase Promoter Contains a Composite SP1-Thyroid Hormone-Retinoic Acid Response Element

1996 • 415 citations

Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist

1994 • 412 citations

The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection

1992 • 400 citations

Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

1990 • 337 citations

Molecular basis for a polymorphism of human Fc gamma receptor II (CD32).

1990 • 299 citations

Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.

1992 • 288 citations

Myeloperoxidase genetic polymorphism and lung cancer risk.

1997 • 240 citations

Recent Advances in Chronic Granulomatous Disease

1983 • 236 citations

Chronic granulomatous disease

1994 • 223 citations

Skewed distribution of IGG FC receptor iia (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients

1995 • 213 citations

Chronic Granulomatous Disease

1977 • 209 citations

X-Linked Chronic Granulomatous Disease: Mutations in the CYBB Gene Encoding the gp91-phox Component of Respiratory-Burst Oxidase

1998 • 207 citations

Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite

1998 • 203 citations

Fca Receptor Iia (Cd32) Polymorphism In Fulminant Meningococcal Septic

1994 • 200 citations

Reactive nitrogen intermediates and antimicrobial activity: Role of nitrite

1993 • 198 citations

Chronic Granulomatous Disease: The Solving of a Clinical Riddle at the Molecular Level

1993 • 185 citations

CD4+ T Cell–mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell–dependent Mechanism Requiring Fc Receptor Signaling

1998 • 185 citations

Fca Receptor Iia (Cd32) Heterogeneity In Patients With Recurrent Bacterial Respiratory Tract Infections

1994 • 181 citations

Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats

1993 • 181 citations

Mannose‐binding protein genetic polymorphisms in black patients with systemic lupus erythematosus

1996 • 161 citations

Mannose-binding protein gene polymorphism in systemic lupus erythematosus

1995 • 158 citations

Corticosteroids in treatment of obstructive lesions of chronic granulomatous disease

1987 • 137 citations

The NADPH oxidase and chronic granulomatous disease

1996 • 130 citations

Chronic Granulomatous Disease Presenting in a 69-Year-Old Man

1991 • 127 citations

Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner.

1995 • 127 citations

Clinical Relevance of Fcγ Receptor Polymorphisms

1997 • 118 citations

Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene.

1995 • 112 citations

Rapid detection of the ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED)

1996 • 97 citations

Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to FcγRIIA alleles

1997 • 96 citations

A single amino acid distinguishes the high‐responder from the low‐responder form of Fc receptor II on human monocytes

1991 • 95 citations

Colitis in chronic granulomatous disease

1982 • 93 citations

Determination of neutrophil antigen gene frequencies in five ethnic groups by polymerase chain reaction with sequence‐specific primers

1996 • 91 citations

A dysfunctional allele of the mannose binding protein gene associates with systemic lupus erythematosus in a Spanish population.

1997 • 87 citations

Systemic lupus erythematosus in a boy with chronic granulomatous disease: Case report and review of the literature

1991 • 80 citations

Discoid lupus erythematosus-like lesions and stomatitis in female carriers of X-linked chronic granulomatous disease

1981 • 74 citations

X-CGDbase: a database of X-CGD-causing mutations

1996 • 73 citations

X-CGDbase: a database of X-CGD-causing mutations

1996 • 71 citations

Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene

1995 • 71 citations

Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats.

1996 • 70 citations

Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase.

1996 • 62 citations

Clinical differences in chronic granulomatous disease in patients with cytochrome b-negative or cytochrome b-positive neutrophils

1985 • 62 citations

Treatment of intractable gastrointestinal manifestations of chronic granulomatous disease with cyclosporine

1995 • 57 citations

Polyarthritis resembling juvenile rheumatoid arthritis in a girl with chronic granulomatous disease

1994 • 53 citations

Host genetics and infectious disease.

1996 • 52 citations

Modulation of granuloma formation by endogenous nitric oxide

1994 • 51 citations

Relationship between genotype and phenotype in monogenic diseases: Relevance to polygenic diseases

1996 • 50 citations

Correlation between Genotype and Phenotype in Patients with Cystic Fibrosis

1994 • 50 citations

Lack of association between an interleukin-1 receptor antagonist gene polymorphism and ulcerative colitis.

1997 • 48 citations

Outpatient management with oral corticosteroid therapy for obstructive conditions in chronic granulomatous disease

1993 • 45 citations

Chronic granulomatous disease

1978 • 45 citations

Relationship between Fc receptor IIA polymorphism and infection in children with sickle cell disease

1996 • 41 citations

Discoid Lupus Erythematosus and X‐linked Chronic Granulomatous Disease

1986 • 38 citations

Urinary Tract Disorders in Patients with Chronic Granulomatous Disease

1989 • 32 citations

Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease

1996 • 30 citations

Chronic granulomatous disease of childhood presenting as gastric outlet obstruction

1982 • 27 citations

Lack of Association between an Interleukin‐I Receptor Antagonist Gene Polymorphism and Systemic Lupus Erythematosus

1994 • 26 citations

Molecular basis of a common opsonic defect

1991 • 25 citations

Discoid lupus erythematosus-like lesions in an autosomal form of chronic granulomatous disease

1986 • 25 citations

Chronic granulomatous disease

1994 • 20 citations

Discoid lupus erythematosus‐like skin lesions in a patient with autosomal recessive chronic granulomatous disease

1986 • 17 citations

The NADPH Oxidase of Leukocytes: The Respiratory Burst Oxidase

1997 • 14 citations

Glomerulonephritis associated with chronic granulomatous disease and systemic lupus erythematosus

1995 • 13 citations

Clinical correlates among 49 families with hemophilia A and factor VIII gene inversions

1996 • 13 citations

Relationship between genotype and phenotype in monogenic diseases: Relevance to polygenic diseases

1996 • 4 citations

Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase

1996 • 3 citations

Deleted Work

1955 • 0 citations