Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Molecular Bases of the Acute Coronary Syndromes

1995 • 2,049 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

1987 • 1,787 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Basement membrane complexes with biological activity

1986 • 1,489 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

The Matrix Metalloproteinases and Their Inhibitors

1992 • 604 citations

Human 92- and 72-kilodalton type IV collagenases are elastases.

1991 • 550 citations

Elastase secretion by stimulated macrophages. Characterization and regulation.

1975 • 522 citations

Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.

1993 • 479 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.

1992 • 304 citations

Purification and amino acid analysis of two human monocyte chemoattractants produced by phytohemagglutinin-stimulated human blood mononuclear leukocytes.

1989 • 304 citations

Detergent-activation of latent collagenase and resolution of its component molecules

1982 • 202 citations

Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.

1992 • 197 citations

Elastolytic Metalloproteinases Produced by Human Mononuclear Phagocytes: Potential Roles in Destructive Lung Disease

1994 • 190 citations

Neutral proteinases of human mononuclear phagocytes. Cellular differentiation markedly alters cell phenotype for serine proteinases, metalloproteinases, and tissue inhibitor of metalloproteinases.

1991 • 179 citations

Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation.

1984 • 166 citations

Human Macrophage Metalloelastase. GENOMIC ORGANIZATION, CHROMOSOMAL LOCATION, GENE LINKAGE, AND TISSUE-SPECIFIC EXPRESSION

1995 • 156 citations

Elastin Degradation by Human Alveolar Macrophages: A Prominent Role of Metalloproteinase Activity

1989 • 122 citations

The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family

1995 • 50 citations

Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages.

1990 • 25 citations