Signal transduction by cGMP in heart

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

A cyclic nucleotide-gated conductance in olfactory receptor cilia

1987 • 1,134 citations

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

1989 • 922 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

1991 • 832 citations

Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel

1989 • 663 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

Mechanisms of calcium channel modulation by β-adrenergic agents and dihydropyridine calcium agonists

1986 • 493 citations

Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.

1991 • 475 citations

Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes

1991 • 468 citations

Elevation of Guanosine 3′,5′-Cyclic Phosphate in Rat Heart after Perfusion with Acetylcholine

1970 • 455 citations

Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel

1986 • 405 citations

Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems

1988 • 403 citations

On the mechanism of ?-adrenergic regulation of the Ca channel in the guinea-pig heart

1985 • 396 citations

Regulatory Mechanisms in the Control of Protein Kinase

1982 • 357 citations

Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells

1986 • 338 citations

Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues.

1982 • 317 citations

The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

1987 • 303 citations

On the mechanism of muscarinic inhibition of the cardiac Ca current

1986 • 283 citations

Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain.

1981 • 279 citations

Stimulation of Adenosine 3',5'-Monophosphate Hydrolysis by Guanosine 3',5'-Monophosphate

1971 • 275 citations

Modulation of Ca current during the phosphorylation cycle in the guinea pig heart

1986 • 254 citations

Cardiac-type excitation-contraction coupling in dysgenic skeletal muscle injected with cardiac dihydropyridine receptor cDNA

1990 • 239 citations

Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation

1991 • 231 citations

Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system

2005 • 226 citations

The cyclic nucleotide-gated channels of vertebrate photoreceptors and olfactory epithelium

1991 • 224 citations

Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle

1988 • 223 citations

Subclasses of cyclic AMP-specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility.

1987 • 218 citations

High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells.

1991 • 218 citations

Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle.

1986 • 214 citations

Dual ion-channel regulation by cyclic GMP and cyclic GMP-dependent protein kinase

1990 • 210 citations

Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues.

1977 • 209 citations

Cyclic guanosine 3',5'‐monophosphate regulates the calcium current in single cells from frog ventricle.

1987 • 199 citations

Regulation of the Cardiac Ryanodine Receptor by Protein Kinase-Dependent Phosphorylation1

1991 • 199 citations

The cDNA of the two isoforms of bovine cGMP‐dependent protein kinase

1989 • 195 citations

Muscarinic control of the hyperpolarization‐activated current (if) in rabbit sino‐atrial node myocytes.

1988 • 178 citations

Potentiation by cyclic GMP of beta‐adrenergic effect on Ca2+ current in guinea‐pig ventricular cells.

1991 • 167 citations

Inhibition of the hyperpolarization‐activated current (if) induced by acetylcholine in rabbit sino‐atrial node myocytes.

1988 • 166 citations

The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells

1982 • 164 citations

Bovine cone photoreceptor cGMP phosphodiesterase structure deduced from a cDNA clone.

1990 • 160 citations

cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones

1986 • 154 citations

Cyclic GMP regulates the Ca-channel current in guinea pig ventricular myocytes

1989 • 148 citations

Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.

1988 • 147 citations

Molecular cloning and predicted full‐length amino acid sequence of the type Iβ isozyme of cGMP‐dependent protein kinase from human placenta

1989 • 147 citations

Regulation of the L-type calcium channel

1987 • 147 citations

Characterization of Sp-5,6-dichloro-1-β-<scp>d</scp>-ribofuranosylbenzimidazole- 3′,5′-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells

1991 • 137 citations

Phosphorylation of cardiac troponin by guanosine 3‘:5‘-monophosphate-dependent protein kinase.

1978 • 134 citations

Time course of the increase in the myocardial slow inward current after a photochemically generated concentration jump of intracellular cAMP.

1983 • 132 citations

Site‐specific phosphorylation of the purified receptor for calcium‐channel blockers by cAMP‐ and cGMP‐dependent protein kinases, protein kinase C, calmodulin‐dependent protein kinase II and casein kinase II

1988 • 131 citations

Does cyclic GMP mediate the negative inotropic effect of acetylcholine in the heart?

1977 • 123 citations

Glucagon stimulates the cardiac Ca2+ current by activation of adenylyl cyclase and inhibition of phosphodiesterase

1990 • 114 citations

cGMP: The wayward child of the cyclic nucleotide family

1991 • 103 citations

Atrial natriuretic factor receptors are negatively coupled to adenylate cyclase in cultured atrial and ventricular cardiocytes

1986 • 99 citations

Effect of calcium on endothelium-derived relaxing factor formation and cGMP levels in endothelial cells

1989 • 92 citations

The expanding family of guanylyl cyclases

1991 • 91 citations

Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue.

1991 • 90 citations

Atriopeptin III induces early relaxation of isolated mammalian papillary muscle.

1988 • 81 citations

Atrial natriuretic factor regulates the calcium current in frog isolated cardiac cells.

1988 • 81 citations

Are increases in cyclic GMP levels responsible for the negative inotropic effects of acetylcholine in the heart?

1977 • 77 citations

cGMP‐dependent protein kinase decreases calcium sensitivity of skinned cardiac fibers

1982 • 75 citations

On the mechanism of histamine induced enhancement of the cardiac Ca2+ current

1987 • 74 citations

Action of atrial natriuretic peptide and angiotensin II on the myocardium: Studies in isolated rat ventricular cardiomyocytes

1989 • 68 citations

8-Bromo-cyclic GMP inhibits the calcium channel current in embryonic chick ventricular myocytes

1990 • 68 citations

Purified cyclic GMP-dependent protein kinase catalyzes the phosphorylation of cardiac troponin inhibitory subunit (TN-1).

1978 • 67 citations

Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells.

1991 • 65 citations

A catalytically active fragment of cGMP-dependent protein kinase. Occupation of its cGMP-binding sites does not affect its phosphotransferase activity

1987 • 64 citations

Cyclic AMP phosphodiesterases and Ca2+ current regulation in cardiac cells

1991 • 63 citations

Correlation of cyclic AMP and cyclic GMP levels with changes in contractile force of dog ventricular myocardium during cholinergic antagonism of positive inotropic actions of histamine, glucagon, theophylline and papaverine.

1979 • 63 citations

Intracellular injection of cyclic GMP depresses cardiac slow action potentials.

1985 • 59 citations

Effect of forskolin and acetylcholine on calcium current in single isolated cardiac myocytes.

1987 • 58 citations

Actions of atrial natriuretic peptide (ANP) on cyclic nucleotide concentrations and phosphatidylinositol turnover in ventricular myocytes

1987 • 58 citations

8-Bromo-guanosine-3′,5′-monophosphate mimics the effect of acetylcholine on slow response action potential and contractile force in mammalian atrial myocardium

1978 • 57 citations

Differing hemodynamic responses to atrial natriuretic factor in two models of hypertension

1986 • 55 citations

Role of phosphodiesterase in regulation of calcium current in isolated cardiac myocytes.

1988 • 55 citations

Phospholamban is a good substrate for cyclic GMP-dependent protein kinase in vitro, but not in intact cardiac or smooth muscle

1989 • 54 citations

Regulation of calcium current by low-Km cyclic AMP phosphodiesterases in cardiac cells.

1990 • 49 citations

G Protein Mediated Regulation of K+ Channels in Heart

1990 • 47 citations

Injection of guanosine 5'-cyclic monophosphate into heart cells blocks calcium slow channels

1985 • 47 citations

Cyclic nucleotide elevating vasodilators inhibit platelet aggregation at an early step of the activation cascade

1989 • 45 citations

Regulation of cardiac cyclic GMP-dependent protein kinase

1981 • 44 citations

Ionic Channels and Adenosine in Isolated Heart Cells

1987 • 40 citations

Evidence that cyclic GMP may regulate cyclic AMP metabolism in the isolated frog ventricle

1981 • 40 citations

Negative inotropic effect of cyclic GMP in cardiac fiber fragments

1976 • 39 citations

Histamine modulates calcium current in guinea pig ventricular myocytes.

1988 • 36 citations

Inhibition of cardiac slow action potentials by 8-bromo-cyclic GMP occurs independent of changes in cyclic AMP levels

1988 • 35 citations

Inotropic responses of the frog ventricle to dibutyryl cyclic AMP and 8-bromo cyclic GMP and related changes in endogenous cyclic nucleotide levels

1981 • 34 citations

Electrophysiological Effects of Cyclic GMP on Canine Cardiac Purkinje Fibers

1985 • 34 citations

Receptor-independent sequestration of beta-adrenergic ligands by alveolar type II cells

1986 • 34 citations

Atrial natriuretic peptide receptors and activation of guanylate cyclase in rat cardiac sarcolemma

1989 • 34 citations

Cyclic-GMP-regulated enzymes and their possible physiological functions.

1984 • 33 citations

Atrial natriuretic factor reduces cyclic adenosine monophosphate content of human fibroblasts by enhancing phosphodiesterase activity.

1988 • 32 citations

Effect of atriopeptin II on Ca influx, contractile behavior and cyclic nucleotide content of cultured neonatal rat myocardial cells

1990 • 32 citations

Molecular cardiology: New avenues for the diagnosis and treatment of cardiovascular disease

1989 • 31 citations

Effects of derivatives of cyclic AMP and cyclic GMP on contraction force of cat papillary muscles

1976 • 28 citations

DIFFERENTIAL RESPONSES TO CARBACHOL, SODIUM NITRO‐PRUSSIDE AND 8‐BROMO‐GUANOSINE 3‘,5’‐MONOPHOSPHATE OF CANINE ATRIAL AND VENTRICULAR MUSCLE

1981 • 25 citations

Adenosine depresses contractility and stimulates 3′,5′ cyclic nucleotide metabolism in the isolated frog ventricle

1980 • 24 citations

Atrial natriuretic peptide reduces the basal level of cytosolic free Ca2+ in guinea pig cardiac myocytes

1990 • 23 citations

Photochemically produced intracellular concentration jumps of cAMP mimic the effects of catecholamines on excitation-contraction coupling in frog atrial fibers

1985 • 20 citations

Are acetylcholine‐induced increases in 42K efflux mediated by intracellular cyclic GMP in turtle cardiac pace‐maker tissue?

1981 • 19 citations

Regulation of gene expression by transfected subunits of cAMP‐dependent protein kinase

1990 • 18 citations

Cardiac Sarcolemmal Substrate of the cGMP-Dependent Protein Kinase

1987 • 17 citations

Cyclic GMP-dependent phosphorylation of an endogenous protein from rat heart

1981 • 16 citations

Inhibition of Platelet Function by Cyclic Nucleotides and Cyclic Nucleotide-Dependent Protein Kinases

1991 • 9 citations

The effect of cGMP in rabbit auricle as studied by a cut-end method

1978 • 7 citations