Inhibition of Platelet Function by Cyclic Nucleotides and Cyclic Nucleotide-Dependent Protein Kinases

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Regulatory Functions of the Vascular Endothelium

1990 • 1,899 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

cAMP-DEPENDENT PROTEIN KINASE: FRAMEWORK FOR A DIVERSE FAMILY OF REGULATORY ENZYMES

1990 • 1,121 citations

Molecular mechanisms of platelet activation.

1989 • 903 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

Syndromes of accelerated atherosclerosis: Role of vascular injury and smooth muscle cell proliferation

1990 • 765 citations

Endothelium-derived relaxing factor

1988 • 686 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Cyclic GMP Metabolism and Involvement in Biological Regulation

1977 • 629 citations

Signal transduction mechanisms involving nitric oxide

1991 • 538 citations

Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.

1991 • 475 citations

Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes

1991 • 468 citations

Developmental mechanisms underlying pathology of arteries

1990 • 445 citations

Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.

1990 • 354 citations

Calcium Signaling in Human Platelets

1990 • 348 citations

Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells

1986 • 338 citations

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.

1990 • 319 citations

Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase.

1988 • 279 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cGMP- and cAMP-elevating vasodilators.

1990 • 270 citations

Thrombosis and haemostasis

1988 • 263 citations

Cyclic GMP and mechanisms of vasodilation

1989 • 260 citations

The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets.

1987 • 245 citations

Multiple isozymes of cyclic nucleotide phosphodiesterase.

1988 • 239 citations

Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.

1988 • 229 citations

Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system

2005 • 226 citations

High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells.

1991 • 218 citations

Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine.

1990 • 190 citations

Anagrelide: A New Drug for Treating Thrombocytosis

1988 • 161 citations

Purification of a vasodilator‐regulated phosphoprotein from human platelets

1989 • 160 citations

Endothelial, platelet and leukocyte interactions in ischemic heart disease: Insights into potential mechanisms and their clinical relevance

1990 • 156 citations

Platelet inhibitor agents in cardiovascular disease: An update

1989 • 143 citations

Vasodilator‐stimulated protein phosphorylation in platelets is mediated by cAMP‐ and cGMP‐dependent protein kinases

1987 • 132 citations

13 Regulation of Contractile Activity

1987 • 118 citations

The Platelets : physiology and pharmacology

1985 • 104 citations

Demonstration of cGMP‐dependent protein kinase and cGMP‐dependent phosphorylation in cell‐free extracts of platelets

1986 • 102 citations

Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets

1991 • 92 citations

Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle

1991 • 83 citations

The interaction of sodium nitroprusside with human endothelial cells and platelets: nitroprusside and prostacyclin synergistically inhibit platelet function.

1982 • 81 citations

Vasoactive effects of growth factors

1989 • 79 citations

Vascular smooth muscle. A review of the molecular basis of contractility.

1991 • 79 citations

Functional relationship between cyclic AMP-dependent protein phosphorylation and platelet inhibition

1990 • 72 citations

Effects of Nitrovasodilators on Platelet Cyclic Nucleotide Levels in Rabbit Blood; Role for Cyclic AMP in Synergistic Inhibition of Platelet Function by SIN-1 and Prostaglandin E1

1991 • 61 citations

Interactions of iloprost and sodium nitroprusside on vascular smooth muscle and platelet aggregation

1989 • 51 citations

The interaction of sodium nitroprusside with human endothelial cells and platelets: nitroprusside and prostacyclin synergistically inhibit platelet function.

1982 • 47 citations

Cyclic nucleotide elevating vasodilators inhibit platelet aggregation at an early step of the activation cascade

1989 • 45 citations

Molecular cardiology: New avenues for the diagnosis and treatment of cardiovascular disease

1989 • 31 citations

Cellular and Molecular Biology of Myelination

1991 • 31 citations

Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from the cytosol of human platelets

1990 • 29 citations

Intracellular mechanism of action of vasodilators

1988 • 29 citations

Calcium and Cyclic AMP: Antagonistic Modulators of Platelet Function

1985 • 25 citations

Cyclic AMP agonists induce the phosphorylation of phospholipase C-τ and of a 76 kDa protein co-precipitated by anti-(phospholipase C-τ) monoclonal antibodies in BALB/c-3T3 cells. Relationship to inositol phosphate formation

1990 • 17 citations

Regulation of Platelet Cyclic AMP Formation

1985 • 16 citations

Selective anti‐platelet aggregation synergism between a prostacyclin‐mimetic, RS93427 and the nitrodilators sodium nitroprusside and glyceryl trinitrate

1989 • 15 citations

Characterization of the protein kinase activities of human platelet supernatant and particulate fractions

1984 • 14 citations

The phosphoprotein that regulates platelet Ca2+ transport is located on the plasma membrane, controls membrane-associated Ca2+-ATPase and is not glycoprotein Ib β-subunit

1991 • 12 citations

cAMP-Dependent Protein Kinase: Subunit Diversity and Functional Role in Gene Expression

1990 • 6 citations