Mice that lack activity of αvβ6- and αvβ8-integrins reproduce the abnormalities ofTgfb1- andTgfb3-null mice

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Making sense of latent TGFβ activation

2002 • 1,579 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

2007 • 1,215 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

2006 • 769 citations

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

2002 • 701 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

Control of T‐cell activation by CD4⁺ CD25⁺ suppressor T cells

2001 • 560 citations

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

2008 • 520 citations

Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema

2003 • 480 citations

A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells

1996 • 479 citations

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

2007 • 477 citations

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

2006 • 454 citations

Developmental regulation of Foxp3 expression during ontogeny

2005 • 418 citations

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

2007 • 391 citations

‘Yin–Yang’ functions of transforming growth factor‐β and T regulatory cells in immune regulation

2007 • 356 citations

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

1996 • 312 citations

Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice

2007 • 298 citations

TGFβ signalling in control of T-cell-mediated self-reactivity

2007 • 294 citations

Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells.

1993 • 290 citations

β8 integrins are required for vascular morphogenesis in mouse embryos

2002 • 266 citations

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

2007 • 257 citations

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients

2007 • 239 citations

Interactions between Growth Factors and Integrins: Latent Forms of Transforming Growth Factor-β Are Ligands for the Integrin αvβ1

1998 • 229 citations

Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death

2004 • 219 citations

Increased Expression of Integrin αvβ3 Contributes to the Establishment of Autocrine TGF-β Signaling in Scleroderma Fibroblasts

2005 • 217 citations

Integrin-mediated activation of latent transforming growth factor β

2005 • 193 citations

αvβ6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse

2007 • 186 citations

Vascular Development of the Brain Requires β8 Integrin Expression in the Neuroepithelium

2005 • 164 citations

The integrin α_Vβ₆ binds and activates latent TGFβ3

2001 • 160 citations

Function-blocking Integrin αvβ6 Monoclonal Antibodies

2004 • 153 citations

Synaptic and glial localization of the integrin αvβ8 in mouse and rat brain

1998 • 146 citations

Involvement of αvβ5 integrin–mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts

2005 • 129 citations

The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3

2003 • 119 citations

Integrin α8β1 mediates adhesion to LAP-TGFβ1

2002 • 78 citations

Integrin-Mediated Transforming Growth Factor-β Activation Regulates Homeostasis of the Pulmonary Epithelial-Mesenchymal Trophic Unit

2006 • 75 citations

TGFβ1 and TGFβ3 are partially redundant effectors in brain vascular morphogenesis

2008 • 59 citations

Integrin β6 Mediates Phospholipid and Collectin Homeostasis by Activation of Latent TGF-β1

2007 • 39 citations

Appearance of Langerhans Cells in the Epidermis of Tgfb1−/− SCID Mice: Paracrine and Autocrine Effects of Transforming Growth Factor-β1 and -β21

2001 • 20 citations

Deleted Work

1955 • 0 citations

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