Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease

2004 • 3,455 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Making sense of latent TGFβ activation

2002 • 1,579 citations

Site and Nature of Airway Obstruction in Chronic Obstructive Lung Disease

1968 • 1,357 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

The Relations between Structural Changes in Small Airways and Pulmonary-Function Tests

1978 • 851 citations

An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct

1994 • 749 citations

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

2002 • 701 citations

Mediators of Chronic Obstructive Pulmonary Disease

2004 • 700 citations

Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

1986 • 570 citations

Keratins and the Keratinocyte Activation Cycle

2001 • 520 citations

Genetic programs of epithelial cell plasticity directed by transforming growth factor-β

2001 • 520 citations

MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines

2006 • 512 citations

cDNA Cloning and Sequence Analysis of βig-h3, a Novel Gene Induced in a Human Adenocarcinoma Cell Line after Treatment with Transforming Growth Factor-β

1992 • 502 citations

Genes Encoding Structural Proteins of Epidermal Cornification and S100 Calcium-Binding Proteins Form a Gene Complex (“Epidermal Differentiation Complex”) on Human Chromosome 1q21

1996 • 498 citations

Latent Transforming Growth Factor-β (TGF-β) Binding Proteins: Orchestrators of TGF-β Availability

2004 • 414 citations

Interleukin-1β Causes Pulmonary Inflammation, Emphysema, and Airway Remodeling in the Adult Murine Lung

2005 • 409 citations

Increased Expression of Transforming Growth Factor- β 1 in Small Airway Epithelium from Tobacco Smokers and Patients with Chronic Obstructive Pulmonary Disease (COPD)

2001 • 364 citations

Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor β1–induced Pulmonary Fibrosis

2004 • 352 citations

Transforming Growth Factor β₁and Recruitment of Macrophages and Mast Cells in Airways in Chronic Obstructive Pulmonary Disease

1998 • 307 citations

Airway Epithelial Repair, Regeneration, and Remodeling after Injury in Chronic Obstructive Pulmonary Disease

2006 • 305 citations

Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice

2007 • 298 citations

Culture and transformation of human airway epithelial cells

1995 • 290 citations

Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism

1999 • 288 citations

The Pathogenesis of Chronic Obstructive Pulmonary Disease

2005 • 256 citations

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.

1994 • 250 citations

IL-13 and Epidermal Growth Factor Receptor Have Critical but Distinct Roles in Epithelial Cell Mucin Production

2006 • 239 citations

The transforming growth factor- 1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)

2004 • 225 citations

Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis.

1995 • 194 citations

Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

2001 • 194 citations

Collagen matrix promotes reorganization of pancreatic endocrine cell monolayers into islet-like organoids.

1983 • 185 citations

p63 In pulmonary epithelium, pulmonary squamous neoplasms, and other pulmonary tumors

2002 • 180 citations

Heparan Sulfate Mediates bFGF Transport through Basement Membrane by Diffusion with Rapid Reversible Binding

1999 • 173 citations

Myofibroblast Differentiation Is Induced in Keratinocyte-Fibroblast Co-Cultures and Is Antagonistically Regulated by Endogenous Transforming Growth Factor-β and Interleukin-1

2004 • 172 citations

Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β by Perivascular Astrocytes

2005 • 167 citations

NF-κB and Activator Protein 1 Response Elements and the Role of Histone Modifications in IL-1β-Induced TGF-β1 Gene Transcription

2006 • 165 citations

The Attenuated Fibroblast Sheath of the Respiratory Tract Epithelial–Mesenchymal Trophic Unit

1999 • 165 citations

Mesenchyme specifies epithelial differentiation in reciprocal recombinants of embryonic lung and trachea

1998 • 164 citations

Effect of Cigarette Smoke on the Permeability and IL-1 β and sICAM-1 Release from Cultured Human Bronchial Epithelial Cells of Never-Smokers, Smokers, and Patients with Chronic Obstructive Pulmonary Disease

2000 • 155 citations

Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.

1994 • 122 citations

Early detection of COPD: A case finding study in general practice

2006 • 110 citations

Identification of Human Epidermal Differentiation Complex (EDC)-Encoded Genes by Subtractive Hybridization of Entire YACs to a Gridded Keratinocyte cDNA Library

2001 • 107 citations

Long-Term Impact of Smoking on Lung Epithelial Proliferation in Current and Former Smokers

2001 • 101 citations

Differential regulation of airway epithelial integrins by growth factors.

1996 • 97 citations

A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth.

2000 • 90 citations

EFFECTS OF MEDIA ON DIFFERENTIATION OF CULTURED HUMAN TRACHEAL EPITHELIUM

2003 • 83 citations

A Novel Protease Inhibitor of the α2-Macroglobulin Family Expressed in the Human Epidermis

2005 • 81 citations

Expression of the Human Integrin β 6 Subunit in Alveolar Type II Cells and Bronchiolar Epithelial Cells Reverses Lung Inflammation in β 6 Knockout Mice

1998 • 76 citations

Integrin-Mediated Transforming Growth Factor-β Activation Regulates Homeostasis of the Pulmonary Epithelial-Mesenchymal Trophic Unit

2006 • 75 citations

Multistep process of squamous differentiation in tracheobronchial epithelial cells in vitro: analogy with epidermal differentiation.

1989 • 73 citations

Differential Expression of Connexins During Stratification of Human Keratinocytes

2000 • 72 citations

Expression of keratins 1, 6, 15, 16, and 20 in normal cervical epithelium, squamous metaplasia, cervical intraepithelial neoplasia, and cervical carcinoma.

1993 • 63 citations

Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β Inhibits Human Airway Epithelial Proliferation in Intact Bronchial Tissue

2003 • 61 citations

Synovial proinflammatory cytokines and their correlation with matrix metalloproteinase-3 expression in Behçet’s disease. Does interleukin-1β play a major role in Behçet’s synovitis?

2005 • 50 citations

A role for interleukin-1 in epidermal differentiation: Regulation by expression of functional versus decoy receptors

1995 • 45 citations

Expression of the serine protease DESC1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progression

2005 • 29 citations

Role of glycogen synthase kinase 3 in squamous differentiation induced by cigarette smoke in porcine tracheobronchial epithelial cells

2006 • 28 citations

Detection of early squamous metaplasia in bladder biopsies of spinal cord injury patients by immunostaining for cytokeratin 14

2003 • 16 citations

Multistep Process of Squamous Differentiation in Tracheobronchial Epithelial Cells In Vitro: Analogy with Epidermal Differentiation

1989 • 13 citations

Precocious appearance of markers of squamous differentiation in metaplastic cells of human endocervix

1989 • 5 citations