Microglial release of nitric oxide by the synergistic action of β-amyloid and IFN-γ

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1991 • 2,375 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Histochemical mapping of nitric oxide synthase in the rat brain

1992 • 1,858 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

1989 • 904 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

1988 • 702 citations

Turnover of resident microglia in the normal adult mouse brain

1992 • 679 citations

Synthesis of nitric oxide in CNS glial cells

1993 • 627 citations

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

1989 • 586 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

Tumor Necrosis Factor and Granulocyte Macrophage-Colony Stimulating Factor Stimulate Human Macrophages to Restrict Growth of Virulent Mycobacterium avium and to Kill Avirulent M. avium: Killing Effector Mechanism Depends on the Generation of Reactive Nitrogen Intermediates

1991 • 390 citations

Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ

1993 • 355 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

BASIC AND CLINICAL IMMUNOLOGY

1988 • 246 citations

Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies

1993 • 232 citations

Progress in neuropathology

1971 • 225 citations

Effects of colony stimulating factors on isolated microglia in vitro

1990 • 216 citations

Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease

1992 • 213 citations

β-Amyloid and the Pathogenesis of Alzheimer's Disease

1991 • 201 citations

Production of nitrite by neonatal rat microglial cells/ brain macrophages

1992 • 198 citations

The possible contribution of microglia and macrophages to delayed neuronal death after ischemia

1993 • 197 citations

β-Amyloid protein promotes neuritic branching in hippocampal cultures

1990 • 188 citations

Graft-vs.-host disease elicits expression of class I and class II histocompatibility antigens and the presence of scattered T lymphocytes in rat central nervous system.

1987 • 178 citations

Activation of Macrophages by Alzheimer β Amyloid Peptide

1994 • 175 citations

Nerve growth factor potentiates the neurotoxicity of beta amyloid.

1990 • 171 citations

Interferon-gamma: A Review

1989 • 156 citations

Basic and Clinical Immunology

1977 • 152 citations

Morphological transformation of microglia in vitro

1991 • 151 citations

Nitric Oxide Production and Neurotoxicity Mediated by Activated Microglia from Human versus Mouse Brain

1994 • 128 citations

Evaluation of nitrite production by human monocyte-derived macrophages

1992 • 117 citations

Induction of basic Fibroblast Growth Factor in Alzheimerʼs disease pathology

1990 • 112 citations

Microglia in cerebellar plaques in Alzheimer's disease

1990 • 106 citations

Interleukin-1 stimulates the beta-amyloid precursor protein promoter

1990 • 95 citations

Reactions of the Immune System in Chronic Degenerative Neurological Diseases

1991 • 87 citations

Inhibition of Interleukin-1- -Induced Nitric Oxide Synthase in Vascular Smooth Muscle and Full Reversal of Interleukin-1- -Induced Hypotension by N -Amino-L-arginine

1992 • 76 citations

Microglia Present Myelin Antigens to T Cells after Phagocytosis of Oligodendrocytes

1993 • 60 citations

Regulation of microglial function by interferons

1992 • 58 citations

Progress in Neuropathology

1981 • 57 citations

Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are Beta-cell specific

1991 • 52 citations

Early senile plaques in Alzheimer's disease demonstrated by histochemistry, immunocytochemistry, and electron microscopy

1990 • 46 citations