In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Cell Death

2004 • 4,599 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

2004 • 1,977 citations

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

2005 • 1,751 citations

p53 Has a Direct Apoptogenic Role at the Mitochondria

2003 • 1,735 citations

p53 Regulates Mitochondrial Respiration

2006 • 1,600 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly

2005 • 1,152 citations

Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

2007 • 1,110 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

2003 • 862 citations

Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

2004 • 748 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53

2005 • 527 citations

Bim is a suppressor of Myc-induced mouse B cell leukemia

2004 • 485 citations

Expression of bbc3 , a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

2001 • 402 citations

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

2006 • 380 citations

In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation

2004 • 368 citations

Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

2001 • 354 citations

Integral role of Noxa in p53-mediated apoptotic response

2003 • 326 citations

BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

2005 • 262 citations

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

2006 • 241 citations

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

2006 • 225 citations

PUMA Dissociates Bax and Bcl-XL to Induce Apoptosis in Colon Cancer Cells

2006 • 178 citations

Suppression of tumorigenesis by the p53 target PUMA

2004 • 178 citations

Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.

1993 • 177 citations

The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage

2007 • 159 citations

Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

1995 • 126 citations

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

2007 • 123 citations

DNA-damaging agents induce both p53-dependent and p53-independent apoptosis in immature thymocytes.

1996 • 25 citations