The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 • 1,975 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

Intrinsic tumour suppression

2004 • 1,267 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Developmental and tissue-specific regulation of mouse telomerase and telomere length.

1995 • 686 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Hypervariable ultra-long telomeres in mice

1990 • 612 citations

The role of p53 in determining sensitivity to radiotherapy

2003 • 549 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

1994 • 366 citations

A novel p16INK4A transcript.

1995 • 348 citations

The common and distinct target genes of the p53 family transcription factors

2004 • 293 citations

Temporal dissection of p53 function in vitro and in vivo

2005 • 183 citations

Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice

2004 • 151 citations

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

2003 • 148 citations

Improving cancer therapy by non-genotoxic activation of p53

2003 • 91 citations

Could p53 be a target for therapeutic suppression?

1998 • 50 citations

Atm Is Dispensable for p53 Apoptosis and Tumor Suppression Triggered by Cell Cycle Dysfunction

1999 • 42 citations