Structural Insights into How the MIDAS Ion Stabilizes Integrin Binding to an RGD Peptide under Force

VMD: Visual molecular dynamics

1996 • 54,630 citations

Comparison of simple potential functions for simulating liquid water

1983 • 37,746 citations

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

1993 • 26,634 citations

All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins

1998 • 13,827 citations

Constant pressure molecular dynamics simulation: The Langevin piston method

1995 • 4,126 citations

RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

2003 • 2,476 citations

NAMD2: Greater Scalability for Parallel Molecular Dynamics

1999 • 2,396 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

2002 • 1,571 citations

Probing the Relation Between Force—Lifetime—and Chemistry in Single Molecular Bonds

2001 • 1,294 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3

2001 • 1,256 citations

Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

2002 • 1,134 citations

Steered molecular dynamics and mechanical functions of proteins

2001 • 1,002 citations

Structural Basis of Collagen Recognition by Integrin α2β1

2000 • 945 citations

Ligand Binding: Molecular Mechanics Calculation of the Streptavidin-Biotin Rupture Force

1996 • 913 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

The relationship between force and focal complex development

2002 • 876 citations

Calculating potentials of mean force from steered molecular dynamics simulations

2004 • 871 citations

N-Methylated Cyclic RGD Peptides as Highly Active and Selective α_Vβ₃Integrin Antagonists

1999 • 803 citations

Molecular dynamics study of unbinding of the avidin-biotin complex

1997 • 774 citations

Distribution and Evolution of von Willebrand/Integrin A Domains: Widely Dispersed Domains with Roles in Cell Adhesion and Elsewhere

2002 • 696 citations

Conformational Regulation of Integrin Structure and Function

2002 • 536 citations

Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions

2000 • 402 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

Integrin activation and structural rearrangement

2002 • 386 citations

Force Measurements of the α5β1 Integrin–Fibronectin Interaction

2003 • 369 citations

Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension

2002 • 355 citations

Single Integrin Molecule Adhesion Forces in Intact Cells Measured by Atomic Force Microscopy

1999 • 286 citations

The Key Event in Force-Induced Unfolding of Titin’s Immunoglobulin Domains

2000 • 284 citations

Talin1 is critical for force-dependent reinforcement of initial integrin–cytoskeleton bonds but not tyrosine kinase activation

2003 • 271 citations

Crystal structure of a complex between anthrax toxin and its host cell receptor

2004 • 244 citations

Components of cell-matrix adhesions

2001 • 200 citations

New insights into the structural basis of integrin activation

2003 • 199 citations

Coming to grips with integrin binding to ligands

2002 • 190 citations

Defining Fibronectin's Cell Adhesion Synergy Site by Site-Directed Mutagenesis

2000 • 182 citations

Supramolecular chemistry and self-assembly

2002 • 180 citations

A structural model for force regulated integrin binding to fibronectin's RGD-synergy site

2002 • 167 citations

The Structures of Integrins and Integrin–Ligand Complexes: Implications for Drug Design and Signal Transduction

2002 • 167 citations

Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster

2003 • 154 citations

Reconstructing Potentials of Mean Force through Time Series Analysis of Steered Molecular Dynamics Simulations

1999 • 136 citations

Short-term binding of fibroblasts to fibronectin: optical tweezers experiments and probabilistic analysis

2000 • 130 citations

Tuning the Mechanical Stability of Fibronectin Type III Modules through Sequence Variations

2004 • 107 citations

Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring

2004 • 96 citations

Role of ADMIDAS Cation-binding Site in Ligand Recognition by Integrin α5β1

2003 • 93 citations

Locking the β3 Integrin I-like Domain into High and Low Affinity Conformations with Disulfides

2004 • 86 citations

Binding of Anthrax Toxin to Its Receptor Is Similar to α Integrin-Ligand Interactions

2003 • 75 citations

Early mechanistic events in biotin dissociation from streptavidin

2002 • 49 citations

Will the Real Integrin Please Stand Up?

2002 • 34 citations