Locking the β3 Integrin I-like Domain into High and Low Affinity Conformations with Disulfides

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

Integrins

2002 • 8,127 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

2002 • 1,571 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3

2001 • 1,256 citations

Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

2002 • 1,134 citations

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.

1987 • 1,087 citations

Structural Basis of Collagen Recognition by Integrin α2β1

2000 • 945 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

2003 • 784 citations

Accurate modeling of protein conformation by automatic segment matching

1992 • 558 citations

Conformational Regulation of Integrin Structure and Function

2002 • 536 citations

Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

2003 • 518 citations

[25] Ribbons

1997 • 511 citations

Structure of integrin 5 1 in complex with fibronectin

2003 • 332 citations

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

2002 • 313 citations

Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activityin vivo

2001 • 214 citations

Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains

2001 • 184 citations

The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1.

1997 • 150 citations

Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

2003 • 146 citations

A Redox Site Involved in Integrin Activation

2000 • 138 citations

An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond

2001 • 129 citations

Integrin Activation Involves a Conformational Change in the α1 Helix of the β Subunit A-domain

2002 • 128 citations

Conformational Changes in the Integrin औA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

2003 • 120 citations

Multiple Discontinuous Ligand-mimetic Antibody Binding Sites Define a Ligand Binding Pocket in Integrin αIIbβ3

2000 • 97 citations

Role of ADMIDAS Cation-binding Site in Ligand Recognition by Integrin α5β1

2003 • 93 citations

Folding of the β-propeller domain of the integrin α_Lsubunit is independent of the I domain and dependent on the β₂ subunit

1997 • 73 citations

Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds

2002 • 64 citations

New isolation procedure and further biochemical characterization of glycoproteins IIb and IIIa from human platelet plasma membrane

1986 • 42 citations

Thiol-specific probes indicate that the .beta.-chain of platelet glycoprotein Ib is a transmembrane protein with a reactive endofacial sulfhydryl group

1985 • 21 citations