Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

The crystal structure of diphtheria toxin

1992 • 663 citations

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

1986 • 517 citations

The crystal structure of pertussis toxin

1994 • 343 citations

The Three-dimensional Crystal Structure of Cholera Toxin

1995 • 343 citations

Molecular and biochemical features of poly (ADP-ribose) metabolism

1993 • 300 citations

Refined Structure of Escherichia coli Heat-labile Enterotoxin, a Close Relative of Cholera Toxin

1993 • 299 citations

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 • 242 citations

Subunit assembly and active site location in the structure of glutamate dehydrogenase

1992 • 223 citations

A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage.

1995 • 200 citations

Crystal Structure of Diphtheria Toxin Bound to Nicotinamide Adenine Dinucleotide

1996 • 200 citations

NAD(+)-dependent repair of damaged DNA by human cell extracts.

1993 • 191 citations

Role of Glutamic Acid 988 of Human Poly-ADP-ribose Polymerase in Polymer Formation

1995 • 159 citations

Refined structure of dimeric diphtheria toxin at 2.0 Å resolution

1994 • 157 citations

Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase.

1991 • 113 citations

Common features of the NAD‐binding and catalytic site of ADP‐ribosylating toxins

1994 • 111 citations

The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy

1995 • 92 citations

Identification of potential active-site residues in the human poly(ADP-ribose) polymerase.

1993 • 79 citations

Computer modelling of the NAD binding site of ADP‐ribosylating toxins: active‐site structure and mechanism of NAD binding

1991 • 72 citations

The carboxyl-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli, large scale purification, and characterization

1993 • 64 citations

Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log-phase Chinese hamster cells.

1984 • 54 citations

The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin.

1995 • 54 citations

Effect of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in Chinese hamster V79 cells.

1991 • 46 citations

Structure of the Isolated Catalytic Domain of Diphtheria Toxin

1995 • 45 citations

Crystallization and X-ray Crystallogragphic Analysis of Recombinant Chicken Poly (ADP-ribose) Polymerase Catalytic Domain Produced in Sf9 Insect Cells

1994 • 26 citations

Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly(ADP-ribose) synthetase inhibitor

1992 • 26 citations

Poly(ADP-ribose) polymerase: Structure-function relationship

1995 • 23 citations

Common structure of the catalytic sites of mammalian and bacterial toxin ADP-ribosyltransferases

1994 • 22 citations