Inhibition of telomerase limits the growth of human cancer cells

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMES

1971 • 5,049 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

A survey of telomerase activity in human cancer

1997 • 2,747 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase

1997 • 1,252 citations

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

1999 • 1,076 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

1999 • 969 citations

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

1997 • 946 citations

An alternative pathway for yeast telomere maintenance rescues est1− senescence

1993 • 916 citations

Heterogeneity in telomere length of human chromosomes

1996 • 861 citations

Structure and variability of human chromosome ends.

1990 • 833 citations

Absence of cancer–associated changes in human fibroblasts immortalized with telomerase

1999 • 798 citations

Bypass of Senescence After Disruption of p21 ^CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 • 797 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP)

1997 • 687 citations

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1998 • 629 citations

Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas

1998 • 614 citations

Isolation of a Candidate Human Telomerase Catalytic Subunit Gene, Which Reveals Complex Splicing Patterns in Different Cell Types

1997 • 586 citations

Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry

1998 • 561 citations

Human telomerase contains evolutionarily conserved catalytic and structural subunits

1997 • 476 citations

Telomerase, Cell Immortality, and Cancer

1994 • 405 citations

Defining the molecular mechanisms of human cell immortalization

1991 • 384 citations

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

1999 • 384 citations

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

1994 • 360 citations

Inhibition of human telomerase activity by peptide nucleic acids

1996 • 342 citations

Effects of Reverse Transcriptase Inhibitors on Telomere Length and Telomerase Activity in Two Immortalized Human Cell Lines

1996 • 337 citations

Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice

1999 • 322 citations

Reversing Time: Origin of Telomerase

1998 • 308 citations

Two Modes of Survival of Fission Yeast Without Telomerase

1998 • 289 citations

A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification

1991 • 235 citations

The catalytic subunit of yeast telomerase

1997 • 231 citations

Senescence as a mode of tumor suppression.

1991 • 195 citations

Telomerase Activity Is Sufficient To Allow Transformed Cells To Escape from Crisis

1999 • 184 citations

Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation

1998 • 171 citations

Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells

1991 • 156 citations

Expression profile of the putative catalytic subunit of the telomerase gene.

1998 • 152 citations

Immortalized cells with no detectable telomerase activity. A review.

1997 • 90 citations

Inhibition of Telomerase Activity of Melanoma Cellsin Vitroby Antisense Oligonucleotides

1998 • 87 citations

DNA damage-associated dysregulation of the cell cycle and apoptosis control in cells with germ-line p53 mutation.

1997 • 53 citations

Inhibition of human telomerase by a retrovirus expressing telomeric antisense RNA

1998 • 45 citations

BAD partly reverses paclitaxel resistance in human ovarian cancer cells

1998 • 36 citations