The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

Catalyzed reporter deposition, a novel method of signal amplification application to immunoassays

1989 • 765 citations

The drug resistance-related protein LRP is the human major vault protein

1995 • 621 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Catalyzed reporter deposition, a novel method of signal amplification

1991 • 403 citations

The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

1999 • 386 citations

Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a single species of small RNA.

1986 • 333 citations

Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line.

1987 • 266 citations

Vaults Are Up-regulated in Multidrug-resistant Cancer Cell Lines

1998 • 244 citations

Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines

1996 • 214 citations

Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex

1993 • 214 citations

Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors.

1996 • 193 citations

Multidrug Resistance and the Lung Resistance-Related Protein in Human Colon Carcinoma SW-620 Cells

1999 • 186 citations

Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry.

1991 • 185 citations

Clinical multidrug resistance in cancer: A multifactorial problem

1996 • 182 citations

Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line

1991 • 165 citations

Vaults. II. Ribonucleoprotein structures are highly conserved among higher and lower eukaryotes.

1990 • 162 citations

Vaults and Telomerase Share a Common Subunit, TEP1

1999 • 151 citations

Structure of the vault, a ubiquitous celular component

1999 • 129 citations

Unlocking vaults: organelles in search of a function

1991 • 128 citations

Interaction of Vault Particles with Estrogen Receptor in the MCF-7 Breast Cancer Cell

1998 • 108 citations

Characterization of the Sea Urchin Major Vault Protein: A Possible Role for Vault Ribonucleoprotein Particles in Nucleocytoplasmic Transport

1997 • 89 citations

Structural aspects of antibody-antigen interaction revealed through small random peptide libraries

1996 • 76 citations

Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines

1997 • 70 citations

Recombinant Major Vault Protein Is Targeted to Neuritic Tips of PC12 Cells

1999 • 59 citations

A method for exposing hidden antigenic sites in paraformaldehyde-fixed cultured cells, applied to initially unreactive antibodies.

1993 • 57 citations

Vaults: Large cytoplasmic RNP's that associate with cytoskeletal elements

1990 • 33 citations

Identification of novel drug resistance–associated proteins by a panel of rat monoclonal antibodies

1997 • 24 citations

Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP.

1998 • 24 citations

Major vault protein of electric ray is a phosphoprotein.

1998 • 18 citations