Membrane Targeting by C1 and C2 Domains

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Crystal Structure of the PTEN Tumor Suppressor

1999 • 1,011 citations

The Preference of Tryptophan for Membrane Interfaces

1998 • 891 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

C2-domains, Structure and Function of a Universal Ca2+-binding Domain

1998 • 835 citations

The C2 domain calcium‐binding motif: Structural and functional diversity

1996 • 784 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

1998 • 646 citations

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 • 643 citations

New insights into the regulation of protein kinase C and novel phorbol ester receptors

1999 • 600 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 584 citations

Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

1996 • 526 citations

PKCu is a novel, atypical member of the protein kinase C family.

1994 • 519 citations

Comparison of a Structural and a Functional Epitope

1993 • 512 citations

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

1985 • 471 citations

Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.

1994 • 406 citations

The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium

2000 • 358 citations

Crystal structure of calpain reveals the structural basis for Ca2+-dependent protease activity and a novel mode of enzyme activation

1999 • 349 citations

Translocation of the 85-kDa Phospholipase A2 from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen

1995 • 331 citations

Green Fluorescent Protein (GFP)-tagged Cysteine-rich Domains from Protein Kinase C as Fluorescent Indicators for Diacylglycerol Signaling in Living Cells

1998 • 331 citations

Ca2+ bridges the C2 membrane-binding domain of protein kinase Cα directly to phosphatidylserine

1999 • 321 citations

Bipartite Ca ²⁺ -Binding Motif in C ₂ Domains of Synaptotagmin and Protein Kinase C

1996 • 307 citations

PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions

1998 • 289 citations

Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2

1998 • 268 citations

Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers

1998 • 259 citations

Signaling and Subcellular Targeting by Membrane-Binding Domains

2000 • 259 citations

Mechanism of Interaction of Protein Kinase C with Phorbol Esters

1995 • 243 citations

Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain

1998 • 232 citations

Direct Visualization of the Translocation of the γ-Subspecies of Protein Kinase C in Living Cells Using Fusion Proteins with Green Fluorescent Protein

1997 • 228 citations

Translocation and Reversible Localization of Signaling Proteins

2000 • 228 citations

Role of Phosphorylation Sites and the C2 Domain in Regulation of Cytosolic Phospholipase A2

1999 • 207 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 194 citations

Mechanism of Phospholipid Binding by the C₂A-Domain of Synaptotagmin I

1998 • 191 citations

Differential Localization of Protein Kinase C δ by Phorbol Esters and Related Compounds Using a Fusion Protein with Green Fluorescent Protein

1999 • 184 citations

Roles of Trp31 in High Membrane Binding and Proinflammatory Activity of Human Group V Phospholipase A2

1999 • 176 citations

The N-terminal Domain of 5-Lipoxygenase Binds Calcium and Mediates Calcium Stimulation of Enzyme Activity

2000 • 172 citations

Functional Diversity of C2 Domains of Synaptotagmin Family

1995 • 170 citations

Interplay of C1 and C2 Domains of Protein Kinase C-α in Its Membrane Binding and Activation

1999 • 165 citations

The modulation of protein kinase C activity by membrane lipid bilayer structure.

1994 • 163 citations

Differential Roles of Ionic, Aliphatic, and Aromatic Residues in Membrane−Protein Interactions: A Surface Plasmon Resonance Study on Phospholipases A₂

2001 • 150 citations

A Structure-Function Study of the C2 Domain of Cytosolic Phospholipase A2

1999 • 137 citations

Molecular Basis for Protein Kinase C Isozyme-Selective Binding: The Synthesis, Folding, and Phorbol Ester Binding of the Cysteine-Rich Domains of All Protein Kinase C Isozymes

1998 • 136 citations

Three Distinct Mechanisms for Translocation and Activation of the δ Subspecies of Protein Kinase C

1998 • 135 citations

Non-equivalent Roles for the First and Second Zinc Fingers of Protein Kinase Cδ

1996 • 133 citations

Solution structure of a cysteine rich domain of rat protein kinase C

1994 • 131 citations

Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically

1998 • 128 citations

Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine.

1986 • 127 citations

Independent Folding and Ligand Specificity of the C2 Calciumdependent Lipid Binding Domain of Cytosolic Phospholipase A2

1998 • 127 citations

Mapping the Phospholipid-binding Surface and Translocation Determinants of the C2 Domain from Cytosolic Phospholipase A2

1999 • 125 citations

NMR Structure of a Protein Kinase C-γ Phorbol-Binding Domain and Study of Protein−Lipid Micelle Interactions

1997 • 125 citations

The N-terminal “β-Barrel” Domain of 5-Lipoxygenase Is Essential for Nuclear Membrane Translocation

2001 • 122 citations

Roles of Ionic Residues of the C1 Domain in Protein Kinase C-α Activation and the Origin of Phosphatidylserine Specificity

2001 • 121 citations

Distinct Ca2+ Binding Properties of Novel C2 Domains of Plant Phospholipase Dα and β

2000 • 120 citations

Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products

1994 • 120 citations

Ca²⁺-Signaling Cycle of a Membrane-Docking C2 Domain

1997 • 117 citations

Protein Kinase Cα Contains Two Activator Binding Sites That Bind Phorbol Esters and Diacylglycerols with Opposite Affinities

1996 • 114 citations

Interfacial binding of secreted phospholipases A2: more than electrostatics and a major role for tryptophan

1999 • 113 citations

Mutagenesis of the C2 Domain of Protein Kinase C-α

1998 • 112 citations

C2 domain conformational changes in phospholipase C-δ1

1996 • 104 citations

β2-Chimaerin is a novel target for diacylglycerol: Binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain

1999 • 99 citations

Phospholipid Composition Dependence of Ca2+-dependent Phospholipid Binding to the C2A Domain of Synaptotagmin IV

1996 • 91 citations

Interfacial membrane docking of cytosolic phospholipase A ₂ C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance

1999 • 80 citations

Regulation of Receptor-mediated Protein Kinase C Membrane Trafficking by Autophosphorylation

2000 • 80 citations

Location of the Membrane-Docking Face on the Ca²⁺-Activated C2 Domain of Cytosolic Phospholipase A₂

1998 • 79 citations

Differential Membrane-Binding and Activation Mechanisms of Protein Kinase C-α and -ε

1998 • 79 citations

Activation of Phospholipase C δ1 through C2 Domain by a Ca2+-Enzyme-Phosphatidylserine Ternary Complex

1999 • 78 citations

An Essential Role for Autophosphorylation in the Dissociation of Activated Protein Kinase C from the Plasma Membrane

1998 • 77 citations

The Lipophilicity of Phorbol Esters as a Critical Factor in Determining the Pattern of Translocation of Protein Kinase C δ Fused to Green Fluorescent Protein

2000 • 75 citations

Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cdelta: possible correlation with tumor-promoting activity.

1998 • 62 citations

Simultaneous visualization of the translocation of protein kinase Cα–green fluorescent protein hybrids and intracellular calcium concentrations

1999 • 54 citations

Membrane Penetration of Cytosolic Phospholipase A₂ Is Necessary for Its Interfacial Catalysis and Arachidonate Specificity

1998 • 44 citations

Membrane Translocation of Novel Protein Kinase Cs Is Regulated by Phosphorylation of the C2 Domain

2001 • 42 citations

Membrane Targeting and Cytoplasmic Sequestration in the Spatiotemporal Localization of Human Protein Kinase C α

2000 • 36 citations

A Putative Phosphatidylserine Binding Motif Is Not Involved in the Lipid Regulation of Protein Kinase C

1997 • 30 citations