Genetic approaches to TGFβ signaling pathways

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Genome sequence of the nematode C-elegans: A platform for investigating biology

1998 • 3,265 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway

1998 • 1,116 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

1996 • 959 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Organizing activity of wingless protein in Drosophila

1993 • 852 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

Direct and Long-Range Action of a Wingless Morphogen Gradient

1996 • 736 citations

Caenorhabditis elegans : modern biological analysis of an organism

1995 • 689 citations

DPC4 gene in various tumor types.

1996 • 680 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Control of C. elegans Larval Development by Neuronal Expression of a TGF-β Homolog

1996 • 516 citations

Interacting genes in nematode dauer larva formation

1981 • 504 citations

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1998 • 494 citations

The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

1992 • 483 citations

Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

1999 • 475 citations

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

1998 • 469 citations

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

1999 • 436 citations

A human chondrodysplasia due to a mutation in a TGF-β superfamily member

1996 • 412 citations

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

1998 • 368 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1

1997 • 359 citations

Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster

1982 • 345 citations

Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation

1999 • 332 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo

1995 • 312 citations

Mad-related genes in the human

1996 • 308 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2

1998 • 295 citations

daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

1990 • 293 citations

The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo.

1987 • 288 citations

Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo.

1993 • 283 citations

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

1997 • 282 citations

Reverse genetics by chemical mutagenesis in Caenorhabditis elegans

1997 • 282 citations

Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family

1995 • 275 citations

Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic

1994 • 275 citations

BMP5 and the Molecular, Skeletal, and Soft-Tissue Alterations in short ear Mice

1994 • 247 citations

A Screen for Genes That Function Downstream of Ras1 During Drosophila Eye Development

1996 • 246 citations

Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers.

1996 • 242 citations

BMP7 Null Mutation in Mice: Developmental Defects in Skeleton, Kidney, and Eye

1997 • 230 citations

Pioneer Axon Guidance by UNC-129, a C. elegans TGF-β

1998 • 229 citations

Insensitivity to anti–Müllerian hormone due to a mutation in the human anti–Müllerian hormone receptor

1995 • 228 citations

Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals.

1993 • 227 citations

Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.

1995 • 216 citations

schnurri is required for drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1

1995 • 200 citations

The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo.

1994 • 199 citations

The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development

1999 • 190 citations

DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma.

1996 • 164 citations

Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer.

1998 • 154 citations

Mutations of the DPC4/Smad4 gene in biliary tract carcinoma.

1998 • 148 citations

Specificity of TGFβ signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans

1999 • 139 citations

Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis.

1994 • 137 citations

Anti-Müllerian hormone Bruxelles: a nonsense mutation associated with the persistent Müllerian duct syndrome.

1991 • 132 citations

The Drosophila saxophone Gene: a Serine-Threonine Kinase Receptor of the TGF-β Superfamily

1994 • 131 citations

A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling

1995 • 125 citations

SHORTVEIN, A NEW COMPONENT OF THE DECAPENTAPLEGIC GENE COMPLEX IN DROSOPHILA MELANOGASTER

1985 • 114 citations

Identification of Caenorhabditis elegans Genes Required for Neuronal Differentiation and Migration

1998 • 110 citations

Six novel mutations in the endoglin gene in hereditary hemorrhagic telangiectasia type 1 suggest a dominant-negative effect of receptor function

1995 • 109 citations

Loss of functional cell surface transforming growth factor β (TGF-β) type 1 receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia

1997 • 101 citations

TGF-β signaling, Smads, and tumor suppressors

1998 • 100 citations

Identification of Two Smad4 Proteins in Xenopus

1999 • 95 citations

Ras Is Required for a Limited Number of Cell Fates and Not for General Proliferation in Caenorhabditis elegans

1997 • 82 citations

Variants of the anti-M�llerian hormone gene in a compound heterozygote with the persistent M�llerian duct syndrome and his family

1992 • 66 citations

Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.

1996 • 66 citations

Chapter 3 Reverse Genetics: From Gene Sequence to Mutant Worm

1995 • 64 citations

A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A

1998 • 62 citations

BMP 7 Is Required for Nephrogenesis, Eye Development, and Skeletal Patterninga

1996 • 55 citations

TGF-β Knockout and Dominant-Negative Receptor Transgenic Mice

1998 • 51 citations

Mutant Isoforms of the Anti-Müllerian Hormone Type II Receptor Are Not Expressed at the Cell Membrane

1996 • 51 citations

Drosophila dSmad2 and Atr‐I transmit activin/TGFβ signals

1999 • 42 citations

Identification of a New Member of Transforming Growth Factor-Beta Superfamily inDrosophila:The First Invertebrate Activin Gene

1998 • 40 citations

The Liver in Transforming Growth Factor-Beta-1 (TGF-β1) Null Mutant Mice

1996 • 30 citations