The importance of glutathione in human disease

GLUTATHIONE

1983 • 5,487 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

The p38 signal transduction pathway Activation and function

2000 • 1,560 citations

Neuropathology of Parkinsonʼs Disease

1996 • 1,457 citations

Redox Regulation of Cellular Signalling

1999 • 1,146 citations

Tissue-specific functions of individual glutathione peroxidases

1999 • 1,115 citations

Regulation of JNK signaling by GSTp

1999 • 1,102 citations

Oxidative stress and the molecular biology of antioxidant defenses.

1997 • 1,031 citations

Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

1999 • 990 citations

The Isoenzymes of Glutathione Transferase

1985 • 960 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Glutathione: an overview of biosynthesis and modulation

1998 • 896 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

2016 • 864 citations

Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat.

1989 • 781 citations

Glutathione metabolism in brain

2000 • 740 citations

SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS

1989 • 725 citations

Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution

1998 • 678 citations

Glutathione deficiency is associated with impaired survival in HIV disease

1997 • 665 citations

The inactivation of Fe-S cluster containing hydro-lyases by superoxide.

1993 • 628 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Overexpression of glutathione S-transferase/glutathioneperoxidase enhances the growth of transgenic tobacco seedlings during stress

1997 • 581 citations

Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

1992 • 575 citations

Superoxide sensitivity of the Escherichia coli aconitase.

1991 • 499 citations

Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1

2001 • 397 citations

Systemic deficiency of glutathione in cystic fibrosis

1993 • 388 citations

Association Between Glutathione S-Transferase P1, T1, and M1 Genetic Polymorphism and Survival of Patients With Metastatic Colorectal Cancer

2002 • 385 citations

Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens.

1990 • 383 citations

Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses

2002 • 383 citations

Glutathione S-transferase: genetics and role in toxicology

2000 • 375 citations

Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta

1995 • 354 citations

Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction

1998 • 351 citations

Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems

2002 • 346 citations

Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

1997 • 338 citations

The glutathione S-transferases: influence of polymorphism on cancer susceptibility.

1999 • 302 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

Redox regulation of c‐Jun DNA binding by reversible S‐glutathiolation

1999 • 285 citations

Glutathione synthesis is essential for mouse development but not for cell growth in culture

2000 • 277 citations

N‐acetylcysteine replenishes glutathione in HIV infection

2000 • 275 citations

Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases.

2000 • 263 citations

An Electrophile Responsive Element (EpRE) Regulates β-Naphthoflavone Induction of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene

1998 • 260 citations

Metabolic Polymorphisms and Cancer Susceptibility

2012 • 235 citations

Glucose Deprivation-induced Cytotoxicity and Alterations in Mitogen-activated Protein Kinase Activation Are Mediated by Oxidative Stress in Multidrug-resistant Human Breast Carcinoma Cells

1998 • 229 citations

The Level of Intracellular Glutathione Is a Key Regulator for the Induction of Stress-Activated Signal Transduction Pathways Including Jun N-Terminal Protein Kinases and p38 Kinase by Alkylating Agents

1997 • 226 citations

Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13.

1993 • 225 citations

Identification of a Second Region Upstream of the Mouse Heme Oxygenase-1 Gene That Functions as a Basal Level and Inducer-dependent Transcription Enhancer

1995 • 219 citations

Mitochondrial Glutathione: Importance and Transport

1998 • 218 citations

Glutathione S-transferase M1 and T1 polymorphisms: susceptibility to colon cancer and age of onset

1995 • 206 citations

The biochemistry of aging

2001 • 206 citations

Direct Association with Thioredoxin Allows Redox Regulation of Glucocorticoid Receptor Function

1999 • 205 citations

Ultraviolet-Induced Cell Death Blocked by a Selenoprotein from a Human Dermatotropic Poxvirus

1998 • 203 citations

Contribution to characterization of oxidative stress in HIV/AIDS patients

2003 • 199 citations

Overexpression of glutathione S-transferase π enhances the adduct formation of cisplatin with glutathione in human cancer cells

1999 • 184 citations

Formation of 8‐hydroxy‐2′‐deoxyguanosine and 4‐hydroxy‐2‐nonenal‐modified proteins in human renal‐cell carcinoma

1994 • 178 citations

Reduced intravenous glutathione in the treatment of early parkinson's disease

1996 • 170 citations

Rethinking cystic fibrosis pathology: the critical role of abnormal reduced glutathione (GSH) transport caused by CFTR mutation

2001 • 162 citations

Pulmonary dysfunction in cystic fibrosis is associated with oxidative stress

1996 • 149 citations

Biochemical characterization of Drosophila glutathione S-transferases D1 and D21.

1994 • 148 citations

Contribution of genetic factors other than CFTR to disease severity in cystic fibrosis

1998 • 146 citations

Understanding Parkinson's Disease

1997 • 146 citations

Parkinsons Disease - Redox Mechanisms

2001 • 137 citations

Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells.

1998 • 135 citations

Cloning and characterization of two glutathione S-transferases from a DDT-resistant strain of Anopheles gambiae

1997 • 130 citations

The structure of the human glutathione S-transferase π gene

1988 • 129 citations

Oral supplementation with whey proteins increases plasma glutathione levels of HIV‐infected patients

2001 • 126 citations

Glutathione and glutathione-dependent enzymes in cancer drug resistance

1999 • 124 citations

Antioxidant action via p53-mediated apoptosis.

1998 • 121 citations

Studies on the Mechanism of Oxidative Modification of Human Glyceraldehyde-3-phosphate Dehydrogenase by Glutathione: Catalysis by Glutaredoxin

1998 • 118 citations

Molecular Ordering in HIV-induced Apoptosis

1998 • 113 citations

Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis

1999 • 113 citations

Thioredoxin redox control of cell growth and death and the effects of inhibitors

1998 • 107 citations

Overlapping antioxidant response element and PMA responseelement sequences mediate basal and β-naphthoflavone-induced expression of the human γ-glutamylcysteine synthetase catalytic subunit gene

1998 • 107 citations

Augmentation of glutathione in the fluid lining the epithelium of the lower respiratory tract by directly administering glutathione aerosol.

1990 • 104 citations

Oxidative damage to DNA in patients with cystic fibrosis

1995 • 103 citations

Redox Imbalance and Its Control in HIV Infection

2002 • 97 citations

Irreversible Thiol Oxidation in Carbonic Anhydrase III: Protection by S-Glutathiolation and Detection in Aging Rats

2002 • 96 citations

Mutations in the glutathione synthetase gene cause 5–oxoprolinuria

1996 • 93 citations

Disruption of the Microsomal glutathione S-transferase-like gene reduces life span of Drosophila melanogaster

2000 • 89 citations

Construction of a SalI/PstI restriction map of spinach chloroplast dna using low-gelling-temperature-agarose electrophoresis

1980 • 89 citations

S-Adenosyl-l-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease

2002 • 89 citations

Irreversible Inactivation of Protein Kinase C by Glutathione

1998 • 89 citations

Glutathione Reductase: Regulation and Role in Oxidative Stress

1997 • 88 citations

Mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo

1999 • 85 citations

Inherited glutathione-S-transferase deficiency is a risk factor for pulmonary asbestosis.

1994 • 83 citations

Down‐regulation of γ‐glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging

2002 • 76 citations

Hepatic glutathione deficiency in chronic hepatitis C: quantitative evaluation in patients who are HIV positive and HIV negative and correlations with plasmatic and lymphocytic concentrations and with the activity of the liver disease.

1996 • 75 citations

Identification of Cysteine Residues Involved in Disulfide Formation in the Inactivation of Glutathione Transferase P-Form by Hydrogen Peroxide

1993 • 75 citations

Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging

2002 • 71 citations

Characterisation of γ‐glutamylcysteine synthethase‐heavy subunit promoter: a critical role for AP‐1

1998 • 70 citations

Effect of Buthionine Sulfoximine, a Synthesis Inhibitor of the Antioxidant Glutathione, on the Murine Nigrostriatal Neurons

1996 • 66 citations

The Molecular Basis of a Case of γ-Glutamylcysteine Synthetase Deficiency

1999 • 61 citations

Patients with genetic defects in the γ-glutamyl cycle1The Conference on Glutathione and Glutathione linked Enzymes in Human Cancer and other Diseases was held at Hilton Head, South Carolina, October 31–November 3, 1996.1

1998 • 60 citations

The human Hb (MU) class glutathione S-transferases are encoded by a dispersed gene family

1991 • 39 citations

Posttranscriptional Regulation ofMRP/GS-XPump and γ-Glutamylcysteine Synthetase Expression by 1-(4-Amino-2-methyl-5-pyrimidinyl) methyl-3- (2-chloroethyl)-3-nitrosourea and by Cycloheximide in Human Glioma Cells

1997 • 38 citations

Assignment of the gene (GLCLC) that encodes the heavy subunit of γ-glutamylcysteine synthetase to human chromosome 6

1995 • 36 citations

Assignment of the human gene (GLCLR) that encodes the regulatory subunit of γ-glutamylcysteine synthetase to chromosome 1p21

1996 • 34 citations

Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of γ-glutamylcysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5’ untranslated region

1996 • 33 citations

Structure of the human allelic glutathione S-transferase-π gene variant, hGSTP1*C, cloned from a glioblastoma multiforme cell line

1998 • 24 citations

Structure and refinement of the physical mapping of the γ-glutamylcysteine ligase regulatory subunit (GLCLR) gene to chromosome 1p22.1 within the critically deleted region of human malignant mesothelioma

1998 • 22 citations

Is increased tissue ferritin a risk factor for atherosclerosis and ischaemic heart disease?

1995 • 10 citations

The LEC Rat Possesses Reduced Hepatic Selenium, Contributing to the Severity of Spontaneous Hepatitis and Sensitivity to Carcinogenesis

1998 • 8 citations