Redox Imbalance and Its Control in HIV Infection

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

THIOREDOXIN

1985 • 1,885 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Thioredoxin-dependent peroxide reductase from yeast.

1994 • 940 citations

Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study

1999 • 937 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

1989 • 726 citations

SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS

1989 • 725 citations

Glutathione deficiency is associated with impaired survival in HIV disease

1997 • 665 citations

Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

1999 • 597 citations

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.

1996 • 540 citations

Regulatory Role for a Novel Human Thioredoxin Peroxidase in NF-κB Activation

1997 • 414 citations

Glutathione deficiency and human immunodeficiency virus infection

1992 • 409 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase.

1994 • 361 citations

Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients

1989 • 349 citations

Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

1999 • 337 citations

Hemin-induced Activation of the Thioredoxin Gene by Nrf2

2001 • 299 citations

Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects

1998 • 279 citations

N‐acetylcysteine replenishes glutathione in HIV infection

2000 • 275 citations

Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives

1991 • 256 citations

HIV-induced cysteine deficiency and T-cell dysfunction — a rationale for treatment with N-acetylcysteine

1992 • 254 citations

Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide

1994 • 252 citations

Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines.

1992 • 242 citations

Cloning and expression of a cDNA for human thioredoxin.

1988 • 239 citations

The Effect of Cytokines and Pharmacologic Agents on Chronic HIV Infection

1992 • 237 citations

Randomized trial testing the effect of vitamin A supplementation on pregnancy outcomes and early mother-to-child HIV-1 transmission in Durban, South Africa

1999 • 230 citations

Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in HeLa cells.

1993 • 212 citations

Elevation of plasma thioredoxin levels in HIV-infected individuals

1996 • 209 citations

Peroxiredoxin IV Is a Secretable Protein with Heparin-Binding Properties under Reduced Conditions

2000 • 179 citations

Serum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection

2000 • 177 citations

Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer.

2000 • 176 citations

N‐Acetylcysteine suppresses TNF‐induced NF‐κB activation through inhibition of IκB kinases

2000 • 172 citations

Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis.

1997 • 170 citations

Diseases associated with HTLV-I: virus, IL-2 receptor dysregulation and redox regulation

1992 • 166 citations

Stimulation of Glutathione Peroxidase Activity Decreases HIV Type 1 Activation after Oxidative Stress

1994 • 164 citations

N-Acetylcysteine: A New Approach to Anti-HIV Therapy

1992 • 157 citations

Inhibition of NF-κB DNA binding and nitric oxide induction in human T cells and lung adenocarcinoma cells by selenite treatment

1997 • 157 citations

Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine.

1992 • 148 citations

Involvement of thioredoxin in rheumatoid arthritis: its costimulatory roles in the TNF-alpha-induced production of IL-6 and IL-8 from cultured synovial fibroblasts.

1999 • 147 citations

Chronic elevation of plasma thioredoxin: Inhibition of chemotaxis and curtailment of life expectancy in AIDS

2001 • 146 citations

CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses

1991 • 145 citations

Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism

1992 • 138 citations

Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells.

1990 • 137 citations

Measurements of Plasma Glutaredoxin and Thioredoxin in Healthy Volunteers and During Open-Heart Surgery

1998 • 126 citations

Involvement of Thioredoxin in Rheumatoid Arthritis: Its Costimulatory Roles in the TNF-α-Induced Production of IL-6 and IL-8 from Cultured Synovial Fibroblasts

1999 • 122 citations

Improvement of immune functions in HIV infection by sulfur supplementation: Two randomized trials

2000 • 116 citations

Truncated Thioredoxin Is a Mitogenic Cytokine for Resting Human Peripheral Blood Mononuclear Cells and Is Present in Human Plasma

2000 • 113 citations

Glutathione depletion in HIV-infected patients

1992 • 112 citations

Adult T leukemia cells produce a lymphokine that augments interleukin 2 receptor expression.

1985 • 111 citations

Redox and Activation Status of Monocytes from Human Immunodeficiency Virus-Infected Patients: Relationship with Viral Load

1999 • 110 citations

Effect of glutathione depletion and oral N‐acetyl‐cysteine treatment on CD4 ⁺ and CD8 ⁺ cells

1994 • 110 citations

Epstein-Barr virus-containing B-cell line produces an interleukin 1 that it uses as a growth factor.

1987 • 105 citations

Effect of N -acetylcysteine(NAC) treatment on HIV-1 infection: a double-blind placebo-controlled trial

1996 • 104 citations

Cysteine and Glutathione Deficiency in AIDS Patients: A Rationale for the Treatment with IM-Acetyl-Cysteine

1993 • 100 citations

Selenium Supplementation Suppresses Tumor Necrosis Factor α-Induced Human Immunodeficiency Virus Type 1 Replicationin Vitro

1997 • 98 citations

Cerebrospinal fluid S-adenosylmethionine (SAMe) and glutathione concentrations in HIV infection Effect of parenteral treatment with SAMe

1995 • 98 citations

The Redox State as a Correlate of Senescence and Wasting and as a Target for Therapeutic Intervention

1998 • 97 citations

Elevated serum level of thioredoxin in patients with hepatocellular carcinoma.

1998 • 94 citations

Suppression of Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells

1996 • 90 citations

Abnormal Amino-Acid Concentrations in the Blood of Patients with Acquired Immunodeficiency Syndrome (AIDS) May Contribute to the Immunological Defect

1988 • 90 citations

Glutathione and N-Acetylcysteine Suppression of Human Immunodeficiency Virus Replication in Human Monocyte/Macrophages In Vitro

1992 • 80 citations

Thioredoxin Negatively Regulates p38 MAP Kinase Activation and IL-6 Production by Tumor Necrosis Factor-α

1999 • 76 citations

Human Immunodeficiency Virus Induces a Dual Regulation of Bcl-2, Resulting in Persistent Infection of CD4⁺T- or Monocytic Cell Lines

1998 • 74 citations

Vitamin E and alpha-lipoate: Role in antioxidant recycling and activation of the NF-κB transcription factor

1993 • 74 citations

Serum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection

2000 • 71 citations

Selenium supplementation of symptomatic human immunodeficiency virus infected patients

1989 • 66 citations

β-Carotene in HIV infection: an extended evaluation

1996 • 66 citations

Human eosinophil cytotoxicity-enhancing factor. Eosinophil-stimulating and dithiol reductase activities of biosynthetic (recombinant) species with COOH-terminal deletions.

1993 • 62 citations

Opposing regulatory effects of thioredoxin and eosinophil cytotoxicity-enhancing factor on the development of human immunodeficiency virus 1.

1994 • 62 citations

Thioredoxin Blood Level Increases After Severe Burn Injury

2000 • 60 citations

N-Acetylcysteine: Potential for AIDS Therapy

1993 • 58 citations

Glutathione Precursor and Antioxidant Activities ofN-Acetylcysteine and Oxothiazolidine Carboxylate Compared inin VitroStudies of HIV Replication

1994 • 58 citations

Dysregulation of Adult T-Cell Leukemia-Derived Factor (ADF)/Thioredoxin in HIV Infection: Loss of ADF High-Producer Cells in Lymphoid Tissues of AIDS Patients

1992 • 54 citations

Secretion of 10-kDa and 12-kDa Thioredoxin Species from Blood Monocytes and Transformed Leukocytes

2000 • 50 citations

Allosteric Activation of L-Lactate Dehydrogenase Analyzed by Hybrid Enzymes with Effector-sensitive and -insensitive Subunits

1996 • 50 citations

Supplementation ofN-Acetylcysteine Fails to Increase Glutathione in Lymphocytes and Plasma of Patients with AIDS

1995 • 48 citations

Massive Loss of Sulfur in HIV Infection

2000 • 47 citations

Attenuation of ischaemia reperfusion injury by human thioredoxin.

1995 • 45 citations

N-acetylcysteine treatment and the risk of toxic reactions to trimethoprim-sulphamethoxazole in primary Pneumocystis carinii prophylaxis in HIV-infected patients

1997 • 44 citations

Complement-mediated binding of naturally glycosylated and glycosylation-modified human immunodeficiency virus type 1 to human CR2 (CD21)

1993 • 39 citations

Improved Antioxidant Status Among HIV-Infected Injecting Drug Users on Potent Antiretroviral Therapy

2000 • 37 citations

N-Acetylcysteine Enhances Antibody-Dependent Cellular Cytotoxicity in Neutrophils and Mononuclear Cells from Healthy Adults and Human Immunodeficiency Virus-Infected Patients

1995 • 33 citations

N-acetyl-cysteine in the therapy of HIV-positive patients

1999 • 31 citations

Improvement of immune functions in HIV infection by sulfur supplementation: Two randomized trials

2000 • 29 citations

Effects of glutathione precursors on human immunodeficiency virus replication

1994 • 25 citations

A Phase I/II Evaluation of Oral L‐2‐Oxothiazolidine‐4‐Carboxylic Acid in Asymptomatic Patients Infected with Human Immunodeficiency Virus

1998 • 21 citations

Oral N-acetyl-cysteome increases the production of anti HIV chemokines in peripheral blood mononuclear cells

2000 • 17 citations

Beta‐Carotene in HIV Infectiona

1993 • 11 citations

N-acetylcysteine (NAC) enhances interleukin-2 but suppresses interleukin-4 secretion from normal and HIV+ CD4+ T-cells.

1995 • 11 citations