Down‐regulation of γ‐glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Glutathione, oxidative stress and neurodegeneration

2000 • 1,188 citations

Oxidative stress and the pathogenesis of Parkinson's disease

1996 • 967 citations

Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

1997 • 719 citations

Glutathione in Human Plasma: Decline in Association with Aging, Age-Related Macular Degeneration, and Diabetes

1998 • 487 citations

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

1993 • 368 citations

Oxidative stress and antioxidant therapy in Parkinson's disease

1996 • 342 citations

Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells

1994 • 303 citations

Glutathione contents of tissues in the aging mouse

1980 • 268 citations

[59] Glutathione disulfide (GSSG) efflux from cells and tissues

1984 • 197 citations

Identification of a Putative Antioxidant Response Element in the 5′-Flanking Region of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

1995 • 187 citations

Molecular Mechanism of Decreased Glutathione Content in Human Immunodeficiency Virus Type 1 Tat-transgenic Mice

2000 • 166 citations

Oxidative Stress and Parkinson's Diseasea

1996 • 154 citations

Age-associated decline in γ-glutamylcysteine synthetase gene expression in rats

2000 • 141 citations

The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for γ‐glutamylcysteine synthetase and γ‐glutamyl transpeptidase

1999 • 135 citations

On the Cycles of Glutathione Metabolism and Transport

1981 • 120 citations

Differential regulation of γ-glutamylcysteine synthetase heavy and light subunit gene expression

1997 • 118 citations

Cloning and Sequencing of the cDNA for the Light Subunit of Human Liver γ-Glutamylcysteine Synthetase and Relative RNA Levels for Heavy and Light Subunits in Human Normal Tissues

1995 • 118 citations

The Effect of Aging on Glutathione and Cysteine Levels in Different Regions of the Mouse Brain

1989 • 110 citations

Oxidative stress in Parkinson's disease and other neurodegenerative disorders.

1996 • 107 citations

Low glutathione levels in brain regions of aged rats

1989 • 98 citations

γ-Glutamylcysteine synthetase: mRNA stabilization and independent subunit transcription by 4-hydroxy-2-nonenal

1998 • 95 citations

Effect of ageing on human plasma glutathione concentrations as determined by high-performance liquid chromatography with fluorimetric detection

1995 • 88 citations

The role of glutathione in aging and cancer

1992 • 80 citations

Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives

1996 • 77 citations

Glucose transport is reduced in the blood-brain barrier of aged rats

1991 • 75 citations

Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity.

1996 • 74 citations

Glutathione Levels of the Human Crystalline Lens in Aging and Its Antioxidant Effect against the Oxidation of Lens Proteins.

1993 • 67 citations

4-Hydroxy-2-nonenal Increases γ -Glutamylcysteine Synthetase Gene Expression in Alveolar Epithelial Cells

2001 • 53 citations

Activity of glutathione synthesis enzymes in human lens related to age

1982 • 50 citations

Age-related changes of glutathione content, glucose transport and metabolism, and mitochondrial electron transfer function in mouse brain

2001 • 48 citations

Glutathione metabolism in heart and liver of the aging rat

1994 • 46 citations

Studies on the life prolonging effect of food restriction: glutathione levels and glyoxalase enzymes in rat liver

1998 • 37 citations

Bidirectional membrane transport of intact glutathione in Hep G2 cells

1993 • 31 citations

Depletion of cytosolic GSH decreases the ATP levels and viability of synaptosomes from aged mice but not from young mice

1995 • 31 citations

Lenticular glutathione synthesis: rate-limiting factors in its regulation and decline

1984 • 30 citations

[7] Measurement of γ-glutamyl transpeptidase and γ-glutamylcysteine synthetase activities in cells

1995 • 28 citations

Age-related changes in the antioxidant screen of the distal lung in mice

1994 • 24 citations

Effect of oxidant exposure on thiol status in the intestinal mucosa

1993 • 24 citations

External Ca effect on water permeability, regulatory volume decrease, and extracellular space in barnacle muscle cells

1993 • 24 citations

Relationship between age and GSH metabolism in synaptosomes of rat cerebral cortex

1994 • 23 citations

Activity of glutathione synthesis enzymes in the rhesus monkey lens related to age: A model for the human lens

1986 • 20 citations

Age changes in visceral content of glutathione in the senescence accelerated mouse (SAM)

1993 • 16 citations

Glutamyl cysteine synthetase catalytic and regulatory subunits localize to dopaminergic nigral neurons as well as to astrocytes

2001 • 5 citations

Age and GSH metabolism in rat cerebral cortex, as related to oxidative and energy parameters

1993 • 2 citations