Effect of Buthionine Sulfoximine, a Synthesis Inhibitor of the Antioxidant Glutathione, on the Murine Nigrostriatal Neurons

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones.

1978 • 1,073 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it

1992 • 925 citations

Oxygen radicals and the nervous system

1985 • 822 citations

Parkinson's disease: A disorder due to nigral glutathione deficiency?

1982 • 746 citations

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

1988 • 738 citations

Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?

1994 • 701 citations

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

1991 • 516 citations

Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients

1986 • 364 citations

FLUORESCENCE METHODS FOR THE HISTOCHEMICAL DEMONSTRATION OF MONOAMINES. 3. SODIUM BOROHYDRIDE REDUCTION OF THE FLUORESCENT COMPOUNDS AS A SPECIFICITY TEST

1964 • 294 citations

Glutathione depletion and susceptibility.

1984 • 249 citations

Regional lipid peroxidation in rat brain in vitro: Possible role of endogenous iron

1985 • 244 citations

Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra

1987 • 185 citations

Aged mice are more sensitive to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment than young adults

1986 • 174 citations

Aqueous aldehyde (Faglu) methods for the fluorescence histochemical localization of catecholamines and for ultrastructural studies of central nervous tissue

1978 • 146 citations

Chronic dietary pergolide preserves nigrostriatal neuronal integrity in aged-Fischer-344 rats

1992 • 143 citations

Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse

1989 • 141 citations

Depletion of glutathione in brainstem of mice caused by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is prevented by antioxidant pretreatment

1986 • 125 citations

Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease?

1992 • 120 citations

The Effect of Aging on Glutathione and Cysteine Levels in Different Regions of the Mouse Brain

1989 • 110 citations

Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains

1992 • 98 citations

Decreases in protective enzymes correlates with increased oxidative damage in the aging mouse brain

1995 • 97 citations

Role of iron and iron chelation in dopaminergic-induced neurodegeneration: Implication for Parkinson's disease

1992 • 92 citations

THE HISTOCHEMICAL FLUORESCENCE METHOD FOR THE DEMONSTRATION OF CATECHOLAMINES THEORY, PRACTICE AND APPLICATION

1973 • 90 citations

The role of iron in senescence of dopaminergic neurons in Parkinson's disease.

1993 • 83 citations

Age dependence of striatal neuronal death caused by mitochondrial dysfunction

1993 • 80 citations

Depletion of tumour versus normal tissue glutathione by buthionine sulfoximine

1987 • 78 citations

Older dopaminergic neurons do not recover from the effects of MPTP

1987 • 75 citations

Properties of neuronal lipofuscin pigment in mice

1971 • 66 citations

Glutathione depletion in tissues after administration of buthionine sulphoximine

1984 • 57 citations

The possible relation of glutathione, melanin and 1-methyl-4-phenyl-1,2,5,6-tetra-hydropyridine (MPTP) to Parkinson's disease

1984 • 51 citations

Buthionine sulfoximine-induced glutathione depletion

1995 • 38 citations

Aging and unusual catecholamine-containing structures in the mouse brain

1979 • 36 citations

Depletion of Brain Glutathione in Preweanling Mice by L‐Buthionine Sulfoximine

1988 • 35 citations

Intracerebroventricular Administration of <scp>l</scp>‐Buthionine Sulfoximine: A Method for Depleting Brain Glutathione

1989 • 30 citations

Age-correlated changes in dopaminergic nigrostriatal perikarya of the C57BL/6NNia mouse

1984 • 25 citations

Effective depletion of glutathione in rat striatum and substantia nigra by L-buthionine sulfoximine in combination with 2-cyclohexene-1-one

1990 • 19 citations