Interleukin‐4 inhibits χ light chain expression and NFχB activation but not IχBα degradation in 70Z/3 murine pre‐B cells

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

1989 • 741 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1993 • 657 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10

1992 • 516 citations

Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ.

1988 • 487 citations

Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes

1990 • 438 citations

IL-4 down-regulates IL-1 and TNF gene expression in human monocytes.

1989 • 421 citations

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

1990 • 384 citations

The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

1990 • 353 citations

Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.

1991 • 318 citations

Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn.

1993 • 307 citations

Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.

1993 • 302 citations

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors.

1994 • 302 citations

Endotoxin, tumor necrosis factor-α and interleukin 1 induce interleukin 6 production in vivo

1989 • 298 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

1987 • 247 citations

Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation.

1991 • 244 citations

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

1994 • 209 citations

Proteolytic degradation of MAD3 (IϰBα) and enhanced processing of the NF-ϰB precursor p105 are obligatory steps in the activation of NF-ϰB

1993 • 194 citations

CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide.

1994 • 181 citations

Lipopolysaccharide binding protein and CD14 in LPS dependent macrophage activation

1993 • 176 citations

Lipopolysaccharide‐induced cytokine production in human monocytes: Role of tyrosine phosphorylation in transmembrane signal transduction

1994 • 158 citations

Differential inhibition of IL-1 and TNF-alpha mRNA expression by agents which block second messenger pathways in murine macrophages.

1988 • 152 citations

Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes.

1994 • 146 citations

Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.

1994 • 137 citations

Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway.

1994 • 136 citations

Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15

1995 • 135 citations

Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products.

1993 • 133 citations

Interleukin 4 receptor: signaling mechanisms

1994 • 131 citations

Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages.

1993 • 121 citations

Transcription factors: A practical approach

1993 • 108 citations

IL-1 expression in human monocytes is transcriptionally and posttranscriptionally regulated by IL-4.

1991 • 102 citations

Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts.

1993 • 93 citations

Interleukin 1 and tumour necrosis factor activate the mitogen‐activated protein (MAP) kinase kinase in cultured cells

1993 • 73 citations

IL-4 inhibits IL-2 synthesis and IL-2-induced up-regulation of IL-2R alpha but not IL-2R beta chain in CD4+ human T cells.

1991 • 46 citations

Induction and regulation of immunoglobulin expression in a murine pre-B cell line, 70Z/3. I. Cell cycle-associated induction of sIgM expression and kappa-chain synthesis in 70Z/3 cells by LPS stimulation.

1980 • 44 citations

Constitutive secretion of interleukin 1 by human monocytes

1983 • 35 citations

Clinical applications of cytokines.

1994 • 28 citations

Cloning, expression and cross‐linking analysis of the murine p55 tumor necrosis factor receptor

1991 • 28 citations

Up-regulation and down-regulation of cell surface and mRNA expression of CD5 antigen by various humoral factors on murine 70Z/3 pre-B cell leukemia cell line: IL-4 down-regulates CD5 antigen expression

1990 • 13 citations

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