CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Secretory products of macrophages.

1987 • 2,670 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

BIOCHEMISTRY OF ENDOTOXINS

1990 • 1,201 citations

ENDOTOXINS AND DISEASE MECHANISMS

1987 • 1,119 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

1-(5-isoquinol inesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase c in rabbit platelets

1984 • 437 citations

Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide.

1986 • 415 citations

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

1991 • 407 citations

Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

1992 • 402 citations

Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.

1991 • 318 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

Effect of phorbol esters on protein kinase C-zeta.

1992 • 282 citations

Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein.

1992 • 260 citations

Multiple receptors for endotoxin

1991 • 181 citations

Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14.

1993 • 177 citations

Lipopolysaccharide binding protein and CD14 in LPS dependent macrophage activation

1993 • 176 citations

Recognition of Bacterial Endotoxins by Receptor-Dependent Mechanisms

1993 • 159 citations

Specificities of autoinhibitory domain peptides for four protein kinases. Implications for intact cell studies of protein kinase function.

1990 • 154 citations

Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages.

1987 • 150 citations

Pertussis Toxin Inhibition of B Cell and Macrophage Responses to Bacterial Lipopolysaccharide

1986 • 140 citations

Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products.

1993 • 133 citations

Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide

1993 • 128 citations

Lipid A binding sites in membranes of macrophage tumor cells.

1988 • 112 citations

Stimulus-response coupling in monocytes infected with Leishmania. Attenuation of calcium transients is related to defective agonist-induced accumulation of inositol phosphates.

1992 • 90 citations

LPS induces altered phosphate labeling of proteins in murine peritoneal macrophages.

1986 • 88 citations

Lipopolysaccharide Receptors and Signal Transduction Pathways in Mononuclear Phagocytes

1992 • 72 citations

Increased phosphatidylinositol metabolism is an important but not an obligatory early event in B lymphocyte activation.

1985 • 67 citations

Membrane molecules which trigger the production of interleukin‐1 and tumor necrosis factor‐α by lipopolysaccharide‐stimulated human monocytes

1992 • 63 citations

Protein kinase C in tumoricidal activation of mouse macrophage cell lines

1991 • 56 citations

Identification of the sites in myelin basic protein that are phosphorylated by meiosis‐activated protein kinase p44^mpk

1990 • 51 citations

Purification and characterization of the 65-kDa protein phosphorylated in murine macrophages by stimulation with bacterial lipopolysaccharide.

1991 • 49 citations

Secretion of IL-1: role of protein kinase C.

1992 • 47 citations

Involvement of a pertussis toxin-sensitive G-protein-coupled phospholipase A2 in lipopolysaccharide-stimulated prostaglandin E2 synthesis in cultured rat mesangial cells

1988 • 45 citations

Correlation between ribosylation of pertussis toxin substrates and inhibition of peptidoglycan‐, muramyl dipeptide‐ and lipopolysaccharide‐induced mitogenic stimulation in B lymphocytes

1989 • 34 citations

Novel antibodies specific for proteolyzed forms of protein kinase C: production of anti-peptide antibodies available for in situ analysis of intracellular limited proteolysis

1993 • 27 citations

Effects of Pretreatment with Protein Kinase C Activators on Macrophage Activation for Tumor Cytotoxicity, Secretion of Tumor Necrosis Factor, and Its mRNA Expression

1989 • 18 citations

Limited proteolysis of protein kinase C by calpain, its possible implication.

1990 • 13 citations