Endotoxin, tumor necrosis factor-α and interleukin 1 induce interleukin 6 production in vivo

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.

1988 • 791 citations

Interleukin 6 is involved in interleukin 1‐induced activities

1988 • 422 citations

Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.

1988 • 300 citations

The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.

1987 • 295 citations

Interleukin 6 (IL-6) in serum and urine of renal transplant recipients.

1988 • 265 citations

Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice.

1988 • 247 citations

Molecular cloning and expression of hybridoma growth factor in Escherichia coli.

1987 • 238 citations

Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system.

1988 • 229 citations

B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-beta 2, HPGF).

1987 • 220 citations

Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury.

1987 • 214 citations

IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans.

1989 • 201 citations

Serum-free in vitro bioassay for the detection of tumor necrosis factor

1986 • 195 citations

Cytokine regulation of interleukin 6 production by human endothelial cells

1989 • 176 citations

Synergistic activation of human t cells by interleukin 1 and interleukin 6

1988 • 153 citations

Purification and characterization of human interleukin‐1β expressed in recombinant Escherichia coli

1986 • 153 citations

The biology of interleukin 1 and comparison to tumor necrosis factor

1987 • 140 citations

Tumor necrosis factor and interleukin-1: role in acute inflammation and microvascular injury.

1987 • 119 citations

Interleukin-6 in synovial fluid from patients with arthritis

1989 • 105 citations

Induction and regulation of mRNA encoding 26-kDa protein in human cell lines treated with recombinant human tumor necrosis factor.

1987 • 97 citations

Pharmacokinetics of Murine Tumor Necrosis Factor

1986 • 53 citations

A new interleukin with pleiotropic activities

1988 • 29 citations