Interleukin 1 and tumour necrosis factor activate the mitogen‐activated protein (MAP) kinase kinase in cultured cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.

1992 • 370 citations

MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase.

1992 • 256 citations

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.

1992 • 236 citations

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

1992 • 202 citations

Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase.

1993 • 171 citations

Interleukin 1 and tumor necrosis factor activate common multiple protein kinases in human fibroblasts

1991 • 160 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein.

1993 • 128 citations

Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase

1993 • 116 citations

The phorbol ester-dependent activator of the mitogen-activated protein kinase p42mapk is a kinase with specificity for the threonine and tyrosine regulatory sites.

1992 • 111 citations

Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.

1991 • 100 citations

Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.

1990 • 96 citations

Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP

1991 • 91 citations

Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins

1988 • 86 citations

Complementation of byrl in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase

1993 • 73 citations

The amino acid sequence of a mammalian MAP kinase kinase.

1992 • 66 citations

Identification of a cytoplasmic protein kinase regulated by IL-1 that phosphorylates the small heat shock protein, hsp27.

1991 • 45 citations

Identification and characterization of a nerve growth factor-stimulated mitogen-activated protein kinase activator in PC12 cells.

1993 • 31 citations