Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells

Diseases of the Breast

1971 • 1,803 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Endogenous Hormones and Breast Cancer Risk

1993 • 699 citations

Intracrinology

1991 • 654 citations

Male pseudohermaphroditism caused by mutations of testicular 17β–hydroxysteroid dehydrogenase 3

1994 • 561 citations

The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology

1997 • 458 citations

Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity

1993 • 433 citations

Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ⁵-Δ⁴-lsomerase in Human Adrenals and Gonads

1991 • 357 citations

Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis

1995 • 325 citations

Complete amino acid sequence of human placental 17β‐hydroxysteroid dehydrogenase deduced from cDNA

1988 • 298 citations

Regulation of STAT‐dependent pathways by growth factors and cytokines

1996 • 297 citations

Characterization of cDNAs for Human Estradiol 17β-Dehydrogenase and Assignment of the Gene to Chromosome 17: Evidence of two mRNA Species with Distinct 5′-Termini in Human Placenta

1989 • 275 citations

Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women

1986 • 249 citations

Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolution

1995 • 236 citations

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

1995 • 232 citations

Importance of estrogen sulfates in breast cancer

1989 • 230 citations

Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues

1992 • 228 citations

Molecular cloning of a novel widely expressed human 80 kDa 17β-hydroxysteroid dehydrogenase IV

1995 • 211 citations

The structure of a complex of human 17β-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors

1996 • 207 citations

Stimulation of cell proliferation and estrogenic response by adrenal C19-delta 5-steroids in the ZR-75-1 human breast cancer cell line.

1986 • 201 citations

Widespread tissue distribution of steroid sulfatase, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4isomerase(3β-HSD), 17β-HSD5α-reductase and aromatase activities in the rhesus monkey

1994 • 189 citations

THE RELATIONSHIP BETWEEN 17β‐HYDROXYSTEROID DEHYDROGENASE ACTIVITY AND OESTROGEN CONCENTRATIONS IN HUMAN BREAST TUMOURS AND IN NORMAL BREAST TISSUE

1983 • 188 citations

Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2.

1988 • 182 citations

Structure of Two in Tandem Human 17β-Hydroxysteroid Dehydrogenase Genes

1990 • 176 citations

Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma.

1996 • 170 citations

Inhibition of colon and breast carcinoma cell growth by interleukin-4.

1992 • 169 citations

Macrophages in human breast disease: a quantitative immunohistochemical study

1988 • 160 citations

Interleukin 6 decreases cell-cell association and increases motility of ductal breast carcinoma cells.

1989 • 158 citations

Breast Cancer and the Role of Cytokines in Regulating Estrogen Synthesis: An Emerging Hypothesis

1997 • 131 citations

Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells

1994 • 127 citations

Subunit identity of the dimeric 17 beta-hydroxysteroid dehydrogenase from human placenta.

1992 • 118 citations

Apparent Positive Cooperative Effects in Cyclic AMP and Corticosterone Production by Isolated Adrenal Cells in Response to ACTH Analogues

1974 • 116 citations

Regulation of Progesterone-Binding Breast Cyst Protein GCDFP-24 Secretion by Estrogens and Androgens in Human Breast Cancer Cells: A New Marker of Steroid Action in Breast Cancer*

1990 • 113 citations

Testosterone, dihydrotestosterone and oestradiol levels in postmenopausal breast cancer tissues

1995 • 101 citations

Expression and function of members of the cytokine receptor superfamily on breast cancer cells

1997 • 94 citations

A comparison of thein vivo uptake and metabolism of3H-oestrone and3H-oestradiol by normal breast and breast tumour tissues in post-menopausal women

1986 • 93 citations

Flow cytometric analysis of tumour infiltrating lymphocytes in breast cancer

1990 • 89 citations

Effects of human breast fibroblasts on growth and 17β-estradiol dehydrogenase activity of MCF-7 cells in culture

1988 • 82 citations

Interleukin 6 is secreted by breast fibroblasts and stimulates 17β‐oestradiol oxidoreductase activity of MCF‐7 cells: Possible paracrine regulation of breast 17β‐oestradiol levels

1991 • 77 citations

17 beta-hydroxysteroid dehydrogenase gene expression in human breast cancer cells: regulation of expression by a progestin.

1992 • 77 citations

Interleukin-1 alpha and interleukin-6 act additively to inhibit growth of MCF-7 breast cancer cells in vitro.

1993 • 70 citations

Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma

1996 • 65 citations

The Human Type II 17β-Hydroxysteroid Dehydrogenase Gene Encodes Two Alternatively Spliced mRNA Species

1995 • 65 citations

Paracrine influence of human breast stromal fibroblasts on breast epithelial cells: Secretion of a polypeptide which stimulates reductive 17β‐oestradiol dehydrogenase activity

1988 • 64 citations

The interaction of cytokines in regulating oestradiol 17β-hydroxysteroid dehydrogenase activity in MCF-7 cells

1994 • 64 citations

Steroidal regulation of oestradiol-17β dehydrogenase activity of the human breast cancer cell line MCF-7

1988 • 62 citations

Interleukin-4 and interleukin-13 inhibit estrogen-induced breast cancer cell proliferation and stimulate GCDFP-15 expression in human breast cancer cells

1996 • 58 citations

A discussion of the roles of oestrogen and progestin in human mammary carcinogenesis

1991 • 58 citations

Breast Cancer and the Role of Cytokines in Regulating Estrogen Synthesis: An Emerging Hypothesis

1997 • 57 citations

Androgen receptor-mediated stimulation of 17 beta-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells.

1993 • 55 citations

Progestin induction of 17β‐hydroxysteroid dehydrogenase enzyme protein in the t‐47D human breast‐cancer cell line

1990 • 50 citations

The role of estrogens in growth regulation of breast cancer.

1989 • 49 citations

Interleukin-1 Directly Regulates Hormone-Dependent Human Breast Cancer Cell Proliferationin Vitro

1988 • 44 citations

Androgens and breast cancer.

1992 • 44 citations

Molecular biology and genetics of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene family

1996 • 43 citations

Multiple forms of 17β-hydroxysteroid oxidoreductase in human breast tissue

1989 • 43 citations

Retinoic Acids Increase 17β-Hydroxysteroid Dehydrogenase Type 1 Expression in JEG-3 and T47D Cells, but the Stimulation Is Potentiated by Epidermal Growth Factor, 12-O-Tetradecanoylphorbol-13-Acetate, and Cyclic Adenosine 3′,5′-Monophosphate Only in JEG-3 Cells*

1997 • 41 citations

Generation of a Transcription Map at the HSD17B Locus Centromeric to BRCA1 at 17q21

1995 • 41 citations

Interleukin‐6 inhibits the potent stimulatory action of androgens, glucocorticoids and interleukin‐1α on apolipoprotein D and GCDFP‐15 expression in human breast cancer cells

1995 • 40 citations

Interleukin 1 alpha blocks estradiol-stimulated growth and down-regulates the estrogen receptor in MCF-7 breast cancer cells in vitro.

1991 • 38 citations

Effect of Dehydroepiandrosterone and the Antiestrogen EM-800 on Growth of Human ZR-75-1 Breast Cancer Xenografts

1998 • 38 citations

Decreased adherence of interleukin 6-treated breast carcinoma cells can lead to separation from neighbors after mitosis.

1991 • 37 citations

Potent stimulatory effect of interleukin‐1α on apolipoprotein D and gross cystic disease fluid protein‐15 expression in human breast‐cancer cells

1994 • 36 citations

Human tumour-associated NK cells secrete increased amounts of interferon-γ and interleukin-4

1991 • 32 citations

Characterization of 17 beta-hydroxysteroid dehydrogenase IV.

1996 • 31 citations

The JAK/STAT pathway.

1996 • 28 citations

Expression and regulation of 17β-hydroxysteroid dehydrogenase type 1

1996 • 26 citations

Mapping of the HSD17B2 gene encoding type II 17β-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1–q24.2

1995 • 25 citations

Androgen receptor-mediated stimulation of 17 beta-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells

1993 • 21 citations

Expression and regulation of 17 beta-hydroxysteroid dehydrogenase type 1.

1996 • 18 citations

Differential expression of gp200-MR6 molecule in benign hyperplasia and down-regulation in invasive carcinoma of the breast

1996 • 17 citations

The crystallogenesis of a human estradiol dehydrogenase-substrate complex

1996 • 15 citations

Retinoic Acids Increase 17 -Hydroxysteroid Dehydrogenase Type 1 Expression in JEG-3 and T47D Cells, but the Stimulation Is Potentiated by Epidermal Growth Factor, 12-O-Tetradecanoylphorbol-13-Acetate, and Cyclic Adenosine 3',5'-Monophosphate Only in JEG-3 Cells

1997 • 13 citations

Dehydroepiandrosterone and estrone 17-ketosteroid reductases in MCF-7 human breast cancer cells

1990 • 9 citations

Loss of interleukin 4 receptor-associated molecule gp200-MR6 in human breast cancer: prognostic significance

1996 • 8 citations