Effect of Dehydroepiandrosterone and the Antiestrogen EM-800 on Growth of Human ZR-75-1 Breast Cancer Xenografts

Systemic Treatment of Early Breast Cancer by Hormonal, Cytotoxic, or Immune Therapy:133 Randomised Trials involoving 31 000 Recurrences and 24 000 Deaths Among 75 000 Women (Summary)

1993 • 967 citations

Five Versus More Than Five Years of Tamoxifen Therapy for Breast Cancer Patients With Negative Lymph Nodes and Estrogen Receptor-Positive Tumors

1996 • 870 citations

Estrogen Receptors in Human Breast Cancer

1973 • 673 citations

The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology

1997 • 458 citations

Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse.

1988 • 420 citations

Comparison of the Effects of a Pure Steroidal antiestrogen With Those of Tamoxifen in a Model of Human Breast Cancer

1995 • 363 citations

Effect of 12-Month Dehydroepiandrosterone Replacement Therapy on Bone, Vagina, and Endometrium in Postmenopausal Women

1997 • 285 citations

DHEA and Peripheral Androgen and Estrogen Formation: Intracrinology

1995 • 274 citations

Randomized Trial of Two Versus Five Years of Adjuvant Tamoxifen for Postmenopausal Early Stage Breast Cancer

1996 • 258 citations

A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome

1992 • 251 citations

Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens.

1989 • 249 citations

ICI 182,780, a new antioestrogen with clinical potential

1992 • 240 citations

Acquired Tamoxifen Resistance: Correlation With Reduced Breast Tumor Levels of Tamoxifen and Isomerization of Trans-4-Hydroxytamoxifen

1991 • 233 citations

Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) mice by long-term treatment with dehydroepiandrosterone.

1979 • 223 citations

Stimulation of cell proliferation and estrogenic response by adrenal C19-delta 5-steroids in the ZR-75-1 human breast cancer cell line.

1986 • 201 citations

Human breast cancer in the athymic nude mouse: Cystostatic effects of long-term antiestrogen therapy

1987 • 186 citations

Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line

1988 • 174 citations

Androgen receptors in breast cancer

1984 • 167 citations

Androgenic Activity of Dehydroepiandrosterone and Androstenedione in the Rat Ventral Prostate

1988 • 167 citations

Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer.

1979 • 165 citations

(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen

1997 • 154 citations

Androgen receptor gene mutation in male breast cancer

1993 • 139 citations

The future of new pure antiestrogens in clinical breast cancer

1993 • 133 citations

Inhibitory Effect of LHRH and Its Agonists on Testicular Gonadotrophin Receptors and Spermatogenesis in the Rat

1978 • 131 citations

The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth

1994 • 129 citations

Evaluation of Tamoxifen Doses With and Without Fluoxymesterone in Advanced Breast Cancer

1983 • 129 citations

Testosterone Propionate Therapy in Breast Cancer

1964 • 118 citations

Regulation of Progesterone-Binding Breast Cyst Protein GCDFP-24 Secretion by Estrogens and Androgens in Human Breast Cancer Cells: A New Marker of Steroid Action in Breast Cancer*

1990 • 113 citations

Down-Regulation of Estrogen Receptors by Androgens in the ZR-75-1 Human Breast Cancer Cell Line*

1989 • 103 citations

Combination hormonal therapy with tamoxifen plus fluoxymesteroneversus tamoxifen alone in postmenopausal women with metastatic breast cancer. An updated analysis

1991 • 100 citations

Long-term tamoxifen adjuvant therapy in node-positive breast cancer: A metabolic and pilot clinical study

1984 • 99 citations

Fluoxymesterone Therapy in Advanced Breast Cancer

1958 • 98 citations

Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: Problems and potential for future clinical applications

1983 • 98 citations

Androgen and glucocorticoid receptor-mediated inhibition of cell proliferation by medroxyprogesterone acetate in ZR-75-1 human breast cancer cells

1989 • 85 citations

Stimulation of Androgen-Dependent Gene Expression by the Adrenal Precursors Dehydroepiandrosterone and Androstenedione in the Rat Ventral Prostate*

1989 • 80 citations

Androgen sensitivity of the new human breast cancer cell line MFM-223.

1991 • 78 citations

Control of Hormone Receptor Levels and Growth of 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors by Estrogens, Progesterone and Prolactin

1977 • 74 citations

Characterization of the effects of the novel non-steroidal antiestrogen EM-800 on basal and estrogen-induced proliferation of T-47D, ZR-75-1 and MCF-7 human breast cancer cellsin vitro

1997 • 73 citations

Additive inhibitory effects of an androgen and the antiestrogen EM-170 on estradiol-stimulated growth of human ZR-75-1 breast tumors in athymic mice.

1991 • 73 citations

Prevention by dehydroepiandrosterone of the development of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene (DMBA) in the rat

1994 • 72 citations

Inhibitory Effect of Estrogens on GCDFP-15 mRNA Levels and Secretion in ZR-75-1 Human Breast Cancer Cells

1989 • 60 citations

Inhibition of cell cycle kinetics and proliferation by the androgen 5 alpha-dihydrotestosterone and antiestrogen N,n-butyl-N-methyl-11-[16' alpha-chloro-3',17 beta-dihydroxy-estra-1',3',5'-(10')triene-7' alpha-yl] undecanamide in human breast cancer ZR-75-1 cells.

1991 • 59 citations

Effects of estradiol and prolactin on steroid receptor levels in 7,12-dimethylbenz(a)anthracene-induced mammary tumors and uterus in the rat

1978 • 59 citations

Hormonal therapy in cancer of the breast.I. The effect of testosterone propionate therapy on clinical course and hormonal excretion

1951 • 58 citations

Treatment of Breast Cancer with Testosterone Propionate

1944 • 54 citations

Control of aromatase in breast cancer cells and its importance for tumor growth

1993 • 49 citations

The role of estrogens in growth regulation of breast cancer.

1989 • 49 citations

Signal Transduction in Testicular Cells

1996 • 47 citations

Inhibitory effect of androgens on DMBA-induced mammary carcinoma in the rat

1989 • 47 citations

Almost Exclusive Androgenic Action of Dehydroepiandrosterone in the Rat Mammary Gland

1998 • 47 citations

Androgen receptor activity in human breast cancer and its relationship with oestrogen and progestogen receptor activity

1985 • 46 citations

Specific binding of estradiol and dihydrotestosterone in human mammary cancers.

1977 • 42 citations

Characteristics of binding to estrogen, androgen, progestin, and glucocorticoid receptors in 7,12-dimethylbenz(a)anthracene-induced mammary tumors and their hormonal control.

1980 • 40 citations

High bioavailability of dehydroepiandrosterone administered percutaneously in the rat.

1996 • 36 citations

Hormonal Treatment of Advanced Breast Cancer

1995 • 34 citations

The 3β-Hydroxysteroid Dehydrogenase/Isomerase Gene Family: Lessons from Type II 3β-HSD Congenital Deficiency

1996 • 34 citations

Calusterone (7β,17α-DimethyItestosterone) as Primary and Secondary Therapy of Advanced Breast Cancer

1973 • 32 citations

Effect of Dehydroepiandrosterone on Bone Mass, Serum Lipids, and Dimethylbenz(a)anthracene-Induced Mammary Carcinoma in the Rat*

1997 • 30 citations

Antagonism between estrogens and androgens on gcdfp-15 gene expression in ZR-75-1 cells and correlation between GCDFP-15 and estrogen as well as progesterone receptor expression in human breast cancer

1989 • 26 citations

Additive inhibitory effects of bromocryptine (CB-154) and medroxyprogesterone acetate (MPA) on dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in the rat

1989 • 25 citations

Endocrine therapy testing of human breast cancers in the soft agar clonogenic assay

1985 • 22 citations

Counteraction by Prolactin of Androgen-Induced Inhibition of Mammary Tumor Growth in Rats2

1974 • 21 citations

The Effects of Androgens on Induced Mammary Tumours in Rats

1965 • 21 citations

The use of androgens in the treatment of neoplastic disease

1977 • 20 citations

Inhibitory effect of a steroidal antiestrogen (EM-170) on estrone-stimulated growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat

1995 • 14 citations