Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolution

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering

1990 • 727 citations

Estrogenic Regulation of Growth and Polypeptide Growth Factor Secretion in Human Breast Carcinoma

1987 • 576 citations

Male pseudohermaphroditism caused by mutations of testicular 17β–hydroxysteroid dehydrogenase 3

1994 • 561 citations

Interaction of pyrophosphate moieties with .alpha.-helixes in dinucleotide-binding proteins

1985 • 475 citations

Characteristics of short‐chain alcohol dehydrogenases and related enzymes

1991 • 452 citations

Nuclear mechanisms of estrogen action. Effects of estradiol and anti-estrogens on estrogen receptors and nuclear receptor processing.

1978 • 348 citations

Characterization of cDNAs for Human Estradiol 17β-Dehydrogenase and Assignment of the Gene to Chromosome 17: Evidence of two mRNA Species with Distinct 5′-Termini in Human Placenta

1989 • 275 citations

Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family.

1991 • 232 citations

Stimulation of cell proliferation and estrogenic response by adrenal C19-delta 5-steroids in the ZR-75-1 human breast cancer cell line.

1986 • 201 citations

The refined three-dimensional structure of 3α,20β-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases

1994 • 199 citations

Structure of Two in Tandem Human 17β-Hydroxysteroid Dehydrogenase Genes

1990 • 176 citations

Unbiased three-dimensional refinement of heavy-atom parameters by correlation of origin-removed Patterson functions

1983 • 169 citations

Crystal structure of rat liver dihydropteridine reductase.

1992 • 153 citations

Site-specific mutagenesis of Drosophila alcohol dehydrogenase: Evidence for involvement of tyrosine-152 and lysine-156 in catalysis

1993 • 151 citations

Subunit identity of the dimeric 17 beta-hydroxysteroid dehydrogenase from human placenta.

1992 • 118 citations

Tyr-179 and Lys-183 are essential for enzymatic activity of 11β-hydroxysteroid dehydrogenase

1992 • 116 citations

Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme

1991 • 102 citations

11β-Hydroxysteroid dehydrogenase and the short-chain alcohol dehydrogenase (SCAD) superfamily

1992 • 100 citations

Site-directed mutagenesis of the putative active site of human 17β-hydroxysteroid dehydrogenase type 1

1994 • 79 citations

Novel compounds inhibit estrogen formation and action.

1992 • 76 citations

Human Placental 17β-Estradiol Dehydrogenase: Characterization and Structural Studies

1974 • 70 citations

Human Placental 17β-Estradiol Dehydrogenase

1970 • 69 citations

Androstenedione and androst-5-ene-3β,17β-diol stimulate DMBA-induced rat mammary tumors — role of aromatase

1989 • 68 citations

Human placental estradiol 17.beta.-dehydrogenase: sequence of a histidine-bearing peptide inthe catalytic region

1986 • 64 citations

Effects of estradiol and prolactin on steroid receptor levels in 7,12-dimethylbenz(a)anthracene-induced mammary tumors and uterus in the rat

1978 • 59 citations

Genetic mapping of the breast-ovarian cancer syndrome to a small interval on chromosome 17q12–21: exclusion of candidate genes EDH17B2 and RARA

1993 • 58 citations

Crystallization and Preliminary X-ray Diffraction Analysis of the Complex of Human Placental 17β-Hydroxysteroid Dehydrogenase with NADP+

1993 • 57 citations

Mechanism of inhibition of 3α,20β-hydroxysteroid dehydrogenaseby a licorice-derived steroidal inhibitor

1994 • 55 citations

Genealogy of regulation of human sex and adrenal function, prostaglandin action, snapdragon and petunia flower colors, antibiotics, and nitrogen fixation: functional diversity from two ancestral dehydrogenases

1991 • 46 citations

Purification of estradiol-17β dehydrogenase from human placenta by affinity chromatography

1973 • 40 citations

Estradiol 17β-dehydrogenase and 20α-hydroxysteroid dehydrogenase from human placental cytosol: one enzyme with two activities?

1980 • 39 citations

Human 17β-hydroxysteroid dehydrogenase: overproduction using a baculovirus expression system and characterization

1994 • 32 citations

Adrenal steroids stimulate growth and progesterone receptor levels in rat uterus and DMBA-induced mammary tumors

1986 • 29 citations

Inhibition of Streptomyces hydrogenans 3α,20β-hydroxysteroid dehydrogenase by licorice-derived compounds and crystallization of an enzyme-cofactor-inhibitor complex

1992 • 26 citations

Synthesis of 2-bromoacetamidoestrone methyl ether and study of the steroid-binding site of human placental estradiol 17 beta-dehydrogenase.

1980 • 19 citations

Synthesis of 4-bromoacetamidoestrone methyl ether and study of the steroid binding site of human placental estradiol 17beta-dehydrogenase.

1978 • 19 citations

Affinity labeling of human placental 17.beta.-estradiol dehydrogenase and 20.alpha.-hydroxysteroid dehydrogenase with 5'-[p-(fluorosulfonyl)benzoyl]adenosine

1981 • 17 citations

Steroid metabolizing enzymes associated with the microvillar membrane of human placenta

1986 • 15 citations

Chemical modification of lysine residues at active-site of human placental estradiol 17β-dehydrogenase

1988 • 8 citations